Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katie J. Molohon"'
Autor:
Jeremy R. Hershfield, Seongjin Park, Tucker Maxson, Taekjip Ha, Nathan E. Schroeder, Kristen M. Flatt, Douglas A. Mitchell, Katie J. Molohon, Patricia M. Blair, James R. Doroghazi
Publikováno v:
ACS Infectious Diseases. 2:207-220
Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus. Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d728a5922f7402ce54ad066166a5d448
https://doi.org/10.1021/acsinfecdis.5b00115
https://doi.org/10.1021/acsinfecdis.5b00115
Autor:
Lici A. Schurig-Briccio, Kai Li, Benoit Lechartier, Lucio H. Freitas-Junior, Feifei Ren, Venugopal Pujari, Rey-Ting Guo, Douglas A. Mitchell, Tong Jiang, Eric Oldfield, Hong Sun, Peter Orlean, Shannon Bogue, Dean C. Crick, Xinxin Feng, Wei Zhu, Katie J. Molohon, Guodong Rao, Yi Liang Liu, Stewart T. Cole, Anmol Gulati, Hongliang Yang, Ashutosh Upadhyay, Fabio L. Fontes, Giovana Aparecida de Souza Cintra, Robert B. Gennis, Joo Hwan No, Yujie Li
Publikováno v:
Journal of Medicinal Chemistry; Vol 57
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry
We report the discovery of a series of new drug leads that have potent activity against Mycobacterium tuberculosis as well as against other bacteria, fungi, and a malaria parasite. The compounds are analogues of the new tuberculosis (TB) drug SQ109 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88981625e909196857c589a5f5e4984a
Autor:
Eric Oldfield, Yonghui Zhang, Mary E. Hensler, Jordan Axelson, Fu Yang Lin, Eunhae Lee, Yang Wang, Douglas A. Mitchell, Ke Wang, Victor Nizet, Rong Cao, Yi Liang Liu, Ran Pang, Katie J. Molohon, Wei Zhu, Kai Li
Publikováno v:
ACS Medicinal Chemistry Letters. 3:402-406
We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926ac177bd98e0dcce3d5374b8dafcbd
https://doi.org/10.1021/ml300038t
https://doi.org/10.1021/ml300038t
Autor:
Stefanie B. Bumpus, Katie J. Molohon, Bradley S. Evans, Jaeheon Lee, Joel O. Melby, Douglas A. Mitchell, Neil L. Kelleher, Kyle L. Dunbar
Publikováno v:
ACS Chemical Biology. 6:1307-1313
The soil-dwelling, plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42 is a prolific producer of complex natural products. Recently, a new FZB42 metabolite, plantazolicin (PZN), has been described as a member of the growing thiazole/oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c891d434e99e388a8d95dbbf7bfee3
https://doi.org/10.1021/cb200339d
https://doi.org/10.1021/cb200339d
Publikováno v:
ACS chemical biology. 8(9)
Plantazolicin (PZN) is a polyheterocyclic natural product derived from a ribosomal peptide that harbors remarkable antibiotic selectivity for the causative agent of anthrax, Bacillus anthracis. To simultaneously establish the structure-activity relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e574678ba1ff096942a300ca97fc1948
https://pubmed.ncbi.nlm.nih.gov/23823732
https://pubmed.ncbi.nlm.nih.gov/23823732
Autor:
Douglas A. Mitchell, Joshua Olson, Kai Li, Yonghui Zhang, Rong Cao, William Sinko, Ke Wang, J. Andrew McCammon, Katie J. Molohon, Yang Wang, Mary E. Hensler, Yi Liang Liu, Anna Sankovsky, Victor Nizet, Wei Zhu, César Augusto F. de Oliveira, Steffen Lindert, Eric Oldfield
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. We report here the discovery and X-ray crystallographic structures of 10 chemically diverse compounds (benzoic, diketo, and phosphonic acids, as well as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16414d2b1fc04859ccd7d03b032780f
https://europepmc.org/articles/PMC3538244/
https://europepmc.org/articles/PMC3538244/
Autor:
Stefanie B. Bumpus, Jaeheon Lee, Neil L. Kelleher, Joel O Melby, Kyle L Dunbar, Douglas A. Mitchell, Katie J. Molohon, Bradley S Evans
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5188ed2fba185e823aee36e6bfdc2370
https://doi.org/10.1096/fasebj.26.1_supplement.552.1
https://doi.org/10.1096/fasebj.26.1_supplement.552.1
Autor:
Romy Scholz, Douglas A. Mitchell, Joachim Vater, Katie J. Molohon, Rainer Borriss, Roderich D. Süssmuth, Andrew L. Markley, Jonny Nachtigall
Here we report on a novel t hiazole/ o xazole- m odified m icrocin (TOMM) from Bacillus amyloliquefaciens FZB42, a Gram-positive soil bacterium. This organism is well known for stimulating plant growth and biosynthesizing complex small molecules that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae36b4933b659028cfea529dfd7d384
https://europepmc.org/articles/PMC3019963/
https://europepmc.org/articles/PMC3019963/