Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katie J. Aldred"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2879 (2023)
Fluoroquinolones are an important class of antibacterials, and rising levels of resistance threaten their clinical efficacy. Gaining a more full understanding of their mechanism of action against their target enzymes—the bacterial type II topoisome
Externí odkaz:
https://doaj.org/article/a262c05a7be14df68b1fb793858dea71
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 17 (2019)
Quinolone antibacterials target the type II topoisomerases gyrase and topoisomerase IV and kill bacterial cells by converting these essential enzymes into cellular poisons. Although much is known regarding the interactions between these drugs and enz
Externí odkaz:
https://doaj.org/article/c9aa05666e3f4e2990da1d3c844d9b06
Publikováno v:
Antibiotics
Antibiotics, Vol 8, Iss 1, p 17 (2019)
Volume 8
Issue 1
Antibiotics, Vol 8, Iss 1, p 17 (2019)
Volume 8
Issue 1
Quinolone antibacterials target the type II topoisomerases gyrase and topoisomerase IV and kill bacterial cells by converting these essential enzymes into cellular poisons. Although much is known regarding the interactions between these drugs and enz
Autor:
Katie J. Aldred, Charles L. Turnbough, Gangqin Li, Sylvia A. McPherson, Heidi A. Schwanz, Robert J. Kerns, Benjamin H. Williamson, Neil Osheroff
Publikováno v:
Biochemistry. 54:1278-1286
CP-115,955 is a quinolone with a 4-hydroxyphenyl at C7 that displays high activity against both bacterial and human type II topoisomerases. To determine the basis for quinolone cross-reactivity between bacterial and human enzymes, the activity of CP-
Autor:
Erin J. Breland, Neil Osheroff, Vladislava Vlčková, Robert J. Kerns, Keir C. Neuman, Marie-Paule Strub, Katie J. Aldred
Publikováno v:
Biochemistry
Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positiv
Publikováno v:
Biochemistry
Quinolones are one of the most commonly prescribed classes of antibacterials in the world and are used to treat a variety of bacterial infections in humans. Because of the wide use (and overuse) of these drugs, the number of quinolone-resistant bacte
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2016, Vol.113(7), pp.E839-E846 [Peer Reviewed Journal]
Mycobacterium tuberculosis is a significant source of global morbidity and mortality. Moxifloxacin and other fluoroquinolones are important therapeutic agents for the treatment of tuberculosis, particularly multidrug-resistant infections. To guide th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a325c1bca2eb16cb183eaf1d73a08cde
http://dro.dur.ac.uk/17358/1/17358.pdf
http://dro.dur.ac.uk/17358/1/17358.pdf
Autor:
Robert J. Kerns, Sylvia A. McPherson, Erin J. Breland, Neil Osheroff, Charles L. Turnbough, Katie J. Aldred
The rise in quinolone resistance is threatening the clinical use of this important class of broad-spectrum antibacterials. Quinolones kill bacteria by increasing the level of DNA strand breaks generated by the type II topoisomerases gyrase and topois
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5adedf3629435ce67f5104674d6511
https://europepmc.org/articles/PMC4249509/
https://europepmc.org/articles/PMC4249509/
Publikováno v:
Molecular Life Sciences ISBN: 9781461464365
Molecular Life Sciences
Molecular Life Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf7f08458810b5bdb5e2944c1a100aa
https://doi.org/10.1007/978-1-4614-6436-5_146-3
https://doi.org/10.1007/978-1-4614-6436-5_146-3
Publikováno v:
Nucleic Acids Research
Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes of quinolone resistance are mutations of a specific serine or acidic residue in the A subun