Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Katie J, Ewer"'
Autor:
Omar Ngoto, Mainga Hamaluba, Emmaloise Gathuri, Sam Provstgaard-Morys, Janet Musembi, Jeremy Aboagye, Lisa Stockdale, Racheal Roberts, Daniel Woods, Francis Ndungu, Kelvias Keter, Adrian V.S. Hill, Katie J. Ewer, Alison Lawrie, Samuel Sang, Philip Bejon, Irene Njau, Benedict Orindi, Melissa Kapulu, Edward Otieno, Mehreen S. Datoo, Duncan Bellamy, Charles Muiruri, Domtila Kimani
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Falciparum malaria remains a global health problem. Two vaccines, based on the circumsporozoite antigen, are available. RTS, S/AS01 was recommended for use in 2021 following the advice of the World Health Organisation (WHO) Strategic Advi
Externí odkaz:
https://doaj.org/article/ea0814482d4b411bacd4c871089026d6
Autor:
Kan Li, Michael Dodds, Rachel L. Spreng, Milite Abraha, Richard H. C. Huntwork, Lindsay C. Dahora, Tinashe Nyanhete, Sheetij Dutta, Ulrike Wille-Reece, Erik Jongert, Katie J. Ewer, Adrian V. S. Hill, Celina Jin, Jennifer Hill, Andrew J. Pollard, S. Munir Alam, Georgia D. Tomaras, S. Moses Dennison
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Diversity in specificity of polyclonal antibody (pAb) responses is extensively investigated in vaccine efficacy or immunological evaluations, but the heterogeneity in antibody avidity is rarely probed as convenient tools are lacking. Here we have dev
Externí odkaz:
https://doaj.org/article/daa2eeeb0ae945ebaa3a3cfd1fe010ec
Autor:
Robert M Mugo, Benedict Orindi, Faiz M Shee, Duncan Bellamy, Jedidah Mwacharo, Katie J Ewer, Philip Bejon, Francis M Ndungu
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286117 (2023)
BackgroundRTS,S/AS01 induced anti-circumsporozoite protein (CSP) IgG antibodies are associated with the vaccine efficacy. There is currently no international standardisation of the assays used in the measurement of anti-CSP IgG antibody concentration
Externí odkaz:
https://doaj.org/article/f791229208084c22b81f445ab3ddbd66
Autor:
Richard Morter, Alfred B. Tiono, Issa Nébié, Oliver Hague, Alphonse Ouedraogo, Amidou Diarra, Nicola K. Viebig, Adrian V. S. Hill, Katie J. Ewer, Sodiomon B. Sirima
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The experimental malaria vaccine ChAd63 MVA ME-TRAP previously showed protective efficacy against Plasmodium falciparum infection in Phase IIa sporozoite challenge studies in adults in the United Kingdom and in a Phase IIb field efficacy trial in Ken
Externí odkaz:
https://doaj.org/article/240454429ddc4eb1b8fa001f9cb31eba
Autor:
Meera Madhavan, Adam J. Ritchie, Jeremy Aboagye, Daniel Jenkin, Samuel Provstgaad-Morys, Iona Tarbet, Danielle Woods, Sophie Davies, Megan Baker, Abigail Platt, Amy Flaxman, Holly Smith, Sandra Belij-Rammerstorfer, Deidre Wilkins, Elizabeth J. Kelly, Tonya Villafana, Justin A. Green, Ian Poulton, Teresa Lambe, Adrian V.S. Hill, Katie J. Ewer, Alexander D. Douglas
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104298- (2022)
Summary: Background: Intranasal vaccination may induce protective local and systemic immune responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine candidates have achieved protection in pre-clinical challenge models, inclu
Externí odkaz:
https://doaj.org/article/c0218306af9949dca4663ba77a6bcb87
Autor:
Pedro M. Folegatti, Kate Harrison, Lorena Preciado-Llanes, Fernando Ramos Lopez, Mustapha Bittaye, Young Chan Kim, Amy Flaxman, Duncan Bellamy, Rebecca Makinson, Jonathan Sheridan, Sasha R. Azar, Rafael Kroon Campos, Mark Tilley, Nguyen Tran, Daniel Jenkin, Ian Poulton, Alison Lawrie, Rachel Roberts, Eleanor Berrie, Shannan L. Rossi, Adrian Hill, Katie J. Ewer, Arturo Reyes-Sandoval
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Chikungunya virus (CHIKV) is a reemerging mosquito-borne virus that has caused outbreaks in various regions of the world. Here the authors present safety and immunogenicity data from a phase 1 trial with the simian adenovirus vectored vaccine ChAdOx1
Externí odkaz:
https://doaj.org/article/e71818edfedb43ec92d1c8c53528e12d
Autor:
Ane Ogbe, Matthew Pace, Mustapha Bittaye, Timothy Tipoe, Sandra Adele, Jasmini Alagaratnam, Parvinder K. Aley, M. Azim Ansari, Anna Bara, Samantha Broadhead, Anthony Brown, Helen Brown, Federica Cappuccini, Paola Cinardo, Wanwisa Dejnirattisai, Katie J. Ewer, Henry Fok, Pedro M. Folegatti, Jamie Fowler, Leila Godfrey, Anna L. Goodman, Bethany Jackson, Daniel Jenkin, Mathew Jones, Stephanie Longet, Rebecca A. Makinson, Natalie G. Marchevsky, Moncy Mathew, Andrea Mazzella, Yama F. Mujadidi, Lucia Parolini, Claire Petersen, Emma Plested, Katrina M. Pollock, Thurkka Rajeswaran, Maheshi N. Ramasamy, Sarah Rhead, Hannah Robinson, Nicola Robinson, Helen Sanders, Sonia Serrano, Tom Tipton, Anele Waters, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Gavin R. Screaton, Alan Winston, Adrian V.S. Hill, Sarah C. Gilbert, Miles Carroll, Andrew J. Pollard, Sarah Fidler, Julie Fox, Teresa Lambe, John Frater
Publikováno v:
JCI Insight, Vol 7, Iss 7 (2022)
Duration of protection from SARS-CoV-2 infection in people living with HIV (PWH) following vaccination is unclear. In a substudy of the phase II/III the COV002 trial (NCT04400838), 54 HIV+ male participants on antiretroviral therapy (undetectable vir
Externí odkaz:
https://doaj.org/article/446dfee8ec4944f5951afc9fd4bc0066
Autor:
Hannah R. Sharpe, Nicholas M. Provine, Georgina S. Bowyer, Pedro Moreira Folegatti, Sandra Belij-Rammerstorfer, Amy Flaxman, Rebecca Makinson, Adrian V.S. Hill, Katie J. Ewer, Andrew J. Pollard, Paul Klenerman, Sarah Gilbert, Teresa Lambe
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Cytomegalovirus (CMV) is a globally ubiquitous pathogen with a seroprevalence of approximately 50% in the United Kingdom. CMV infection induces expansion of immunosenescent T cell and NK cell populations, with these cells demonstrating lower responsi
Externí odkaz:
https://doaj.org/article/e4a4682673c846b98452e03a01c6e769
Autor:
Andrés Noé, Mehreen S. Datoo, Amy Flaxman, Mohammad Ali Husainy, Daniel Jenkin, Duncan Bellamy, Rebecca A. Makinson, Richard Morter, Fernando Ramos Lopez, Jonathan Sheridan, Dimitrios Voukantsis, Naveen Prasad, Adrian V. S. Hill, Katie J. Ewer, Alexandra J. Spencer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Protection from liver-stage malaria requires high numbers of CD8+ T cells to find and kill Plasmodium-infected cells. A new malaria vaccine strategy, prime-target vaccination, involves sequential viral-vectored vaccination by intramuscular and intrav
Externí odkaz:
https://doaj.org/article/54935d5124fa4127948dd2701b4b673f
Autor:
Jonathan Powlson, Daniel Wright, Antra Zeltina, Mark Giza, Morten Nielsen, Tommy Rampling, Navin Venkatrakaman, Thomas A. Bowden, Adrian V.S. Hill, Katie J. Ewer
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2537-2545.e3 (2019)
Summary: Ebolavirus causes highly lethal hemorrhagic fever in humans. The envelope-displayed viral glycoprotein (GP) is the primary target of humoral immunity induced by natural exposure and vaccination. No T cell epitopes in the GP have been charact
Externí odkaz:
https://doaj.org/article/ebe16cc1a325464592d23c4905d28974