Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Katie Ellard"'
Autor:
Miles P. Sparrow, Jane M. Andrews, Susan J. Connor, Alissa Walsh, William A. Bye, Georgia Hume, Katie Ellard, Watson Ng, S. Antoniades
Publikováno v:
Internal Medicine Journal. 47:1263-1269
Background Immunosuppressed IBD patients have an increased risk of HZV infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in others. Aims To describe characteristics of I
Autor:
Gavin Bennett, Anne J. Rüger, John Thomas Feutrill, Rosemary Lynch, Ann Lewis, Anthea L. Newton, Nico Zinn, Tammy Ladduwahetty, Sunose Mihiro, Andrew Cansfield, Giovanna Bergamini, Oliver Rausch, Alan P. Watt, Douglas W. Thomson, Katie Ellard
Publikováno v:
ACS Medicinal Chemistry Letters. 7:768-773
CZ415, a potent ATP-competitive mTOR inhibitor with unprecedented selectivity over any other kinase is described. In addition to a comprehensive characterization of its activities in vitro, in vitro ADME, and in vivo pharmacokinetic data are reported
Autor:
William A, Bye, Miles P, Sparrow, Susan J, Connor, Jane M, Andrews, Katie, Ellard, Watson, Ng, Georgia, Hume, Sally, Antoniades, Alissa J, Walsh
Publikováno v:
Internal medicine journal. 47(11)
Immunosuppressed inflammatory bowel disease (IBD) patients have an increased risk of herpes zoster virus (HZV) infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in other
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4546-4549
Dual PI3Kγ/δ inhibitors have recently been shown to be suitable targets for inflammatory and respiratory diseases. In a recent study we described the discovery of selective PI3Kγ inhibitors based on a triazolopyridine scaffold. Herein, we describe
Autor:
Giovanna Bergamini, Nigel Ramsden, Sunose Mihiro, Gitte Neubauer, Katie Ellard, Kathryn Bell, Thilo Werner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4613-4618
Herein, we disclose the discovery of a series of 7-substituted triazolopyridines which culminated in the identification of 14 (CZC24758), a potent, orally bioavailable small-molecule inhibitor of PI3Kγ, an attractive drug target for inflammatory and
Autor:
Birger Herzog, Rehan Aqil, David L. Selwood, Basil Hartzoulakis, James Nally, Ian Zachary, Rosemary Lynch, Acely Garza-Garcia, Haiyan Jia, Malini Menon, Mark Stewart, Paul C. Driscoll, Snezana Djordjevic, Ashley Jarvis, Katie Ellard, Natalie Winfield, Charles K. Allerston, Chris Chapman, Michelle Tickner, Lili Cheng
Publikováno v:
Journal of Medicinal Chemistry
We report the molecular design and synthesis of EG00229, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1-ligand complexes by NMR spectroscopy and X-ray crystallography. Mutage
Autor:
Katie Ellard, Giovanna Bergamini, Sunose Mihiro, Thilo Werner, Kathryn Bell, Nigel Ramsden, Gitte Neubauer
Publikováno v:
ChemInform. 43
Various 7-substituted triazolopyridines are prepared and shown to be potent PI3Kγ inhibitors.
Autor:
Warren Miller, Giovanna Bergamini, Mihiro Sunose, Jess Taylor, Gitte Neubauer, Andrew Cansfield, Nigel Ramsden, Katie Ellard, Kathryn Bell
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(16)
Herein we describe the SAR of a novel series of 6-aryl-2-amino-triazolopyridines as potent and selective PI3Kγ inhibitors. The 6-aryl-triazolopyridine core was identified by chemoproteomic screening of a kinase focused library. Rapid chemical expans
Autor:
Katie Ellard, Marcus Bantscheff, Satoko Shimamura, Kathryn Bell, Carsten Hopf, Faiza Rharbaoui, Nigel Ramsden, Mikhail M. Savitski, Gerard Drewes, Gitte Neubauer, Raffaella Mangano, Andrew Cansfield, Toby Mathieson, Ivan Plavec, Christina Rau, Friedrich B M Reinhard, Daniel Leggate, Alison O'Mahony, Thilo Werner, Carola Doce, Jessica Perrin, Katrin Müller, Giovanna Bergamini, Oliver Rausch, Emilio Hirsch
Publikováno v:
Nature chemical biology. 8(6)
We devised a high-throughput chemoproteomics method that enabled multiplexed screening of 16,000 compounds against native protein and lipid kinases in cell extracts. Optimization of one chemical series resulted in CZC24832, which is to our knowledge
Autor:
Carola Doce, Friedrich B M Reinhard, Thilo Werner, Raffaella Mangano, Satoko Shimamura, Katrin Müller, Nigel Ramsden, Gerard Drewes, Daniel Leggate, Gitte Neubauer, Jessica Perrin, Toby Mathieson, Alison O'Mahony, Marcus Bantscheff, Andrew Cansfield, Faiza Rharbaoui, Kathryn Bell, Carsten Hopf, Oliver Rausch, Mikhail M. Savitski, Ivan Plavec, Christina Rau, Katie Ellard, Giovanna Bergamini, Emilio Hirsch
Publikováno v:
Nature Chemical Biology. 8:737-737
Nat. Chem. Biol. 8, 576–582 (2012); published online 29 April 2012; corrected after print 16 May 2012 In the version of this article initially published, the name M. Sunose was misspelled in the Acknowledgements. The error has been corrected in the