Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katie E. Flight"'
Autor:
Ziyin Wang, Egon J. Jacobus, David C. Stirling, Stefanie Krumm, Katie E. Flight, Robert F. Cunliffe, Jonathan Mottl, Charanjit Singh, Lucy G. Mosscrop, Leticia Aragão Santiago, Annette B. Vogel, Katalin Kariko, Ugur Sahin, Stephanie Erbar, John S. Tregoning
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102045- (2023)
The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine
Externí odkaz:
https://doaj.org/article/41e7361041324d99b26eb39f9bd0fb8e
Formulation, inflammation, and RNA sensing impact the immunogenicity of self-amplifying RNA vaccines
Autor:
John S. Tregoning, David C. Stirling, Ziyin Wang, Katie E. Flight, Jonathan C. Brown, Anna K. Blakney, Paul F. McKay, Robert F. Cunliffe, Valarmathy Murugaiah, Christopher B. Fox, Mitchell Beattie, Ying K. Tam, Cecilia Johansson, Robin J. Shattock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 29-42 (2023)
To be effective, RNA vaccines require both in situ translation and the induction of an immune response to recruit cells to the site of immunization. These factors can pull in opposite directions with the inflammation reducing expression of the vaccin
Externí odkaz:
https://doaj.org/article/0d6a34fafa0d4648b2111c1434bf06b4
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O'Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-12 (2023)
Abstract Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propyl
Externí odkaz:
https://doaj.org/article/81c9583b032d41f389c366a3cc12589e
Autor:
Christine T Styles, Jie Zhou, Katie E Flight, Jonathan C Brown, Charlotte Lewis, Xinyu Wang, Michael Vanden Oever, Thomas P Peacock, Ziyin Wang, Rosie Millns, John S O’Neill, Alexander Borodavka, Joe Grove, Wendy S Barclay, John S Tregoning, Rachel S Edgar
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1751-1751 (2024)
Externí odkaz:
https://doaj.org/article/f4a74545bc594cc4bcccd449114fd4d7
Autor:
Christine T. Styles, Jie Zhou, Katie E. Flight, Jonathan C. Brown, Michael Vanden Oever, Thomas P. Peacock, Ziyin Wang, Rosie Millns, John S. O’Neill, Wendy S. Barclay, John S. Tregoning, Rachel S. Edgar
Viruses are vulnerable as they transmit between hosts and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d35f8d7f6683fc8e1f5a6ce5a4511fc
https://doi.org/10.1101/2023.02.13.528349
https://doi.org/10.1101/2023.02.13.528349
Levels of Influenza A Virus Defective Viral Genomes Determine Pathogenesis in the BALB/c Mouse Model
Autor:
Rebecca Penn, John S. Tregoning, Katie E. Flight, Laury Baillon, Rebecca Frise, Daniel H. Goldhill, Cecilia Johansson, Wendy S. Barclay
Publikováno v:
Journal of Virology. 96
Defective viral genomes (DVGs), which are generated by the viral polymerase in error during RNA replication, can trigger innate immunity and are implicated in altering the clinical outcome of infection. Here, we investigated the impact of DVGs on inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43feea77fac5376ae684a75384ccd24
https://doi.org/10.1128/jvi.01178-22
https://doi.org/10.1128/jvi.01178-22
Publikováno v:
Nature Reviews. Immunology
Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e3d1541dd128f97ce1363639f6845a
https://doi.org/10.1038/s41577-021-00592-1
https://doi.org/10.1038/s41577-021-00592-1
Autor:
Katrina M. Pollock, Hannah M. Cheeseman, Alexander J. Szubert, Vincenzo Libri, Marta Boffito, David Owen, Henry Bern, Leon R. McFarlane, Jessica O'Hara, Nana-Marie Lemm, Paul McKay, Tommy Rampling, Yee Ting N. Yim, Ana Milinkovic, Cherry Kingsley, Tom Cole, Susanne Fagerbrink, Marites Aban, Maniola Tanaka, Savviz Mehdipour, Alexander Robbins, William Budd, Saul Faust, Hana Hassanin, Catherine A. Cosgrove, Alan Winston, Sarah Fidler, David Dunn, Sheena McCormack, Robin J. Shattock, Kirsty Adams, Fahimah Amini, Nafisah B Atako, Amalina Bakri, Wendy Barclay, Elizabeth Brodnicki, Jonathan C Brown, Ruth Byrne, Rowena Chilvers, Sofia Coelho, Suzanne Day, Monica Desai, Eleanor Dorman, Tamara Elliott, Katie E Flight, James Fletcher, John Galang, Jagruti Gohil, Aneta Gupta, Chris Harlow, Kai Hu, Mohini Kalyan, Dominic Lagrue, Ely Liscano, Cecilia Njenga, Krunal Polra, Derecia A Powlette, Paul Randell, Mary Rauchenberger, Ianto Redknap, Maravic Ricamara, Paul Rogers, Hadijatou Sallah, Karnyart Samnuan, Michael Schumacher, Zareena Shah, Rachel Shaw, Thomas Shaw, Stefan Sivapatham, Susie Slater, Kim Sorley, Regina Storch, Elizabeth Tan, Tricia Tan, Lieze Thielemans, Sarah Whitely, Charlotte Valentine, Jeeva Varghese, Asha Vikraman, Martin Wilkins
Publikováno v:
EClinicalMedicine, Vol 44, Iss, Pp 101262-(2022)
EClinicalMedicine
EClinicalMedicine
Summary: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as a low dose vaccine against COVID-19. Methods: A phase I first-in-human dose-ranging trial of a saRNA COVID-19 vaccine candidate LNP-nCoVsaR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28acc41920bce70d4d6595fa69b972ce
https://eprints.soton.ac.uk/455190/
https://eprints.soton.ac.uk/455190/