Výsledky vyhledávání - "Katie Bourne"

Akademický článek

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Autor: Chanel J. Taylor, David R. Ireland, Irene Ballagh, Katie Bourne, Nicola M. Marechal, Paul R. Turner, David K. Bilkey, Warren P. Tate, Wickliffe C. Abraham

Publikováno v: Neurobiology of Disease, Vol 31, Iss 2, Pp 250-260 (2008)

Secreted amyloid precursor protein-α (sAPPα) levels are reduced during the pathogenesis of Alzheimer's disease, but the significance of this for neural function is not well understood. Here, we show that intrahippocampal infusion of antibodies targ

Externí odkaz: https://doaj.org/article/5f357aedf4874aadac2b8a4648a9ec1f

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Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

Autor: David K. Bilkey, David Ireland, Nicola M. Marechal, Warren P. Tate, Chanel J. Taylor, Wickliffe C. Abraham, Paul R. Turner, Katie Bourne, Irene Ballagh

Publikováno v: Neurobiology of Disease, Vol 31, Iss 2, Pp 250-260 (2008)

Secreted amyloid precursor protein-alpha (sAPP alpha) levels are reduced during the pathogenesis of Alzheimer's disease, but the significance of this for neural function is not well understood. Here, we show that intrahippocampal infusion of antibodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c595269f94d4fffc9e0b17871e904b
http://www.sciencedirect.com/science/article/pii/S0969996108000880

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Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism

Autor: Joanna M. Williams, Katie Bourne, Ana M. Claasen, Warren P. Tate, Sara E. Mason-Parker, Diane Guévremont, Wickliffe C. Abraham

Publikováno v: Neuroscience letters. 460(1)

Secreted amyloid precursor protein-alpha (sAPPalpha) is a neuroprotective and neurotrophic protein derived from the parent APP molecule. We have shown that sAPPalpha enhances long-term potentiation in vivo and can restore spatial memory in rats whose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a1d9eebd40de60bb2567b30a33ecd0
https://pubmed.ncbi.nlm.nih.gov/19463893

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Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents

Autor: Alan Carne, Paul R. Turner, Daniel J. Garama, Wickliffe C. Abraham, Katie Bourne, Warren P. Tate

Publikováno v: Journal of neuroscience methods. 164(1)

The secreted fragment of the amyloid precursor protein (sAPPalpha) generated following cleavage by alpha-secretase is an important mediator of cell function and is both neurotrophic and neuroprotective. HEK 293T cells have been stably integrated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708c0819e2b5dd617d8ee78bd0f44886
https://pubmed.ncbi.nlm.nih.gov/17537517

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Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

Autor: Margaret Ryan, Wickliffe C. Abraham, Warren P. Tate, Joanna M. Williams, Katie Bourne, Gary P. Morris, Bruce G. Mockett

Publikováno v: BMC Genomics

Background: Differential processing of the amyloid precursor protein liberates either amyloid-ß, a causative agent of Alzheimer's disease, or secreted amyloid precursor protein-alpha (sAPPα), which promotes neuroprotection, neurotrophism, neurogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af95fd4d4852194d1a52a35b303d016e
http://europepmc.org/articles/PMC3691674

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