Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Katie B. Holmes"'
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1268-1281 (2020)
Cross‐linking of the B‐cell receptor (BCR) induces transcriptional activation of immediate early genes (IEGs) including EGR1 and DUSP2 in chronic lymphocytic leukaemia (CLL). Here, we have shown that this transcriptional activation correlated wit
Externí odkaz:
https://doaj.org/article/e1a16b42b1b04727afc2b91d8753eff2
Autor:
Fraser Thomas, Darren J. Newton, Pascal F. Lefevre, Katie B. Holmes, Ildar I. Sadreev, Andy C. Rawstron, Charlotte Evans, Pete Hillmen
BackgroundThe Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib provided a breakthrough in the treatment of chronic lymphocytic leukaemia (CLL), but cases of resistance are now emerging. Whilst resistance is commonly associated with mutations in B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe6bb969f2a9316a9f6e3a3b0f27f7e2
https://doi.org/10.21203/rs.3.rs-33939/v1
https://doi.org/10.21203/rs.3.rs-33939/v1
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1268-1281 (2020)
Molecular Oncology
Molecular Oncology
Cross‐linking of the B‐cell receptor (BCR) induces transcriptional activation of immediate early genes (IEGs) including EGR1 and DUSP2 in chronic lymphocytic leukaemia (CLL). Here, we have shown that this transcriptional activation correlated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e2d3d0dd0502cd8eedaf96ba2c3b45
Autor:
Katie B, Holmes, Ildar I, Sadreev, Andy C, Rawstron, Tal, Munir, David R, Westhead, Peter, Hillmen, Pascal F, Lefevre
Publikováno v:
Oncogenesis
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in Western countries. It has recently been shown that the homogeneity of the chromatin landscape between CLL cells contrasts with the important observed genetic heterogeneity of the dis
Autor:
Tom L. Volkert, Jennifer M. Love, Nuria Lopez-Bigas, Sumeet Gupta, Elizaveta V. Benevolenskaya, Tomasz A. Kisiel, Dannielle C. DeWaal, Heather L. Murray, Richard A. Young, Katie B. Holmes
Publikováno v:
Molecular Cell. 31:520-530
Retinoblastoma protein (pRB) mediates cell-cycle withdrawal and differentiation by interacting with a variety of proteins. RB-Binding Protein 2 (RBP2) has been shown to be a key effector. We sought to determine transcriptional regulation by RBP2 geno