Výsledky vyhledávání - "Katie Anne Fopiano"

Akademický článek

Mice with endothelial cell‐selective adhesion molecule deficiency develop coronary microvascular rarefaction and left ventricle diastolic dysfunction

Autor: Vadym Buncha, Katie Anne Fopiano, Liwei Lang, Celestine Williams, Anatolij Horuzsko, Jessica Andrea Filosa, Gaston Kapuku, Zsolt Bagi

Publikováno v: Physiological Reports, Vol 11, Iss 6, Pp n/a-n/a (2023)

Abstract Endothelial cell‐selective adhesion molecule (ESAM) regulates inflammatory cell adhesion and transmigration and promotes angiogenesis. Here, we examined the role of ESAM in cardiac vascularization, inflammatory cell infiltration, and left

Externí odkaz: https://doaj.org/article/514d96ab2ffe4a84a50dcbd6f20cd596

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Akademický článek

The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer’s disease

Autor: Yanna Tian, Katie Anne Fopiano, Vadym Buncha, Liwei Lang, Hayden A. Suggs, Rongrong Wang, R. Daniel Rudic, Jessica A. Filosa, Zsolt Bagi

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

IntroductionThe disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may

Externí odkaz: https://doaj.org/article/e83ac162e11141978cac8661661d4819

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Akademický článek

Role of Caveolae in the Development of Microvascular Dysfunction and Hyperglycemia in Type 2 Diabetes

Autor: Yanna Tian, Katie Anne Fopiano, Vijay S. Patel, Attila Feher, Zsolt Bagi

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

In type 2 diabetes (T2D) microvascular dysfunction can interfere with tissue glucose uptake thereby contributing to the development of hyperglycemia. The cell membrane caveolae orchestrate signaling pathways that include microvascular control of tiss

Externí odkaz: https://doaj.org/article/2c2fe3b7c2c84d0883fa9ca97b39d108

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The Phosphodiesterase-9A inhibitor PF04447943 improves coronary microvascular rarefaction via Peroxiredoxin-5 in the ZSF1 rat model of HFpEF

Autor: Katie Anne Fopiano, William Pearson, Vadym Buncha, Liwei Lang, Nazha Hamdani, Zsolt Bagi

Publikováno v: Physiology. 38

Coronary microvascular dysfunction contributes to the development of left ventricular (LV) diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF), a prevalent symptom that has limited targeted treatment options. Selective pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef21e25569a2fda39bdd233c321067be
https://doi.org/10.1152/physiol.2023.38.s1.5733071

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ADAM17 overexpression improves cerebrovascular vasoreactivity and cognitive function in the APP/PS1 mouse model of Alzheimer's disease

Autor: Katie Anne Fopiano, Yanna Tian, Hayden Suggs, Vadym Buncha, Liwei Lang, Rongrong Wang, Jessica Filosa, Zsolt Bagi

Publikováno v: Physiology. 38

The disintegrin and metalloproteinase 17 (ADAM17) exhibits α-secretase activity, whereby it can prevent the production of neurotoxic amyloid precursor protein-α (APP). ADAM17 is abundantly expressed in vascular endothelial cells and may act to regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf4cafff27645febfb5706487871a559
https://doi.org/10.1152/physiol.2023.38.s1.5733130

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Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease

Autor: Zsolt Bagi, Christopher D. Kroenke, Katie Anne Fopiano, Yanna Tian, Jessica A. Filosa, Larry S. Sherman, Eric B. Larson, C. Dirk Keene, Kiera Degener O’Brien, Philip A. Adeniyi, Stephen A. Back

Publikováno v: GeroScience

Patients with Alzheimer’s disease (AD) often have cerebral white matter (WM) hyperintensities on MRI and microinfarcts of presumed microvascular origin pathologically. Here, we determined if vasodilator dysfunction of WM-penetrating arterioles is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916e14b71d99147e000cfc6c324fe6ed
https://doi.org/10.1007/s11357-022-00585-5

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Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17

Autor: Yanna Tian, R. Daniel Rudic, Vadym Buncha, Katie Anne Fopiano, Jessica A. Filosa, Huijuan Dou, Liwei Lang, Zsolt Bagi

Publikováno v: GeroScience

Physiological and pathological vascular remodeling is uniquely driven by mechanical forces from blood flow in which wall shear stress (WSS) mechanosensing by the vascular endothelium plays a pivotal role. This study aimed to determine the novel role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b036f90093b4155c02a3e8d5c0f94
https://doi.org/10.1007/s11357-021-00476-1

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