Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Katie A. O'Brien"'
Autor:
Katie A. O’Brien, Ben D. McNally, Alice P. Sowton, Antonio Murgia, James Armitage, Luke W. Thomas, Fynn N. Krause, Lucas A. Maddalena, Ian Francis, Stefan Kavanagh, Dominic P. Williams, Margaret Ashcroft, Julian L. Griffin, Jonathan J. Lyon, Andrew J. Murray
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Tissue hypoxia is a key feature of several endemic hepatic diseases, including alcoholic and non-alcoholic fatty liver disease, and organ failure. Hypoxia imposes a severe metabolic challenge on the liver, potentially disrupting i
Externí odkaz:
https://doaj.org/article/e6fa613deccb4bec8cc1aae51e72dedf
Autor:
James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner, John B. West, Jiao Zhang, John Y. Shyy, Ainash Childebayeva, José Pablo Vázquez-Medina, Luu V. Pham, Omar A. Mesarwi, James E. Hall, Zachary A. Cheviron, Jeremy Sieker, Arlin B. Blood, Jason X. Yuan, Graham R. Scott, Brinda K. Rana, Paul J. Ponganis, Atul Malhotra, Frank L. Powell, Tatum S. Simonson
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypo
Externí odkaz:
https://doaj.org/article/ad6281793d794d10a1e325e2249296a9
Autor:
Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin
Publikováno v:
Redox Biology, Vol 41, Iss , Pp 101907- (2021)
Background: Numerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiti
Externí odkaz:
https://doaj.org/article/9c66267adf404de2a8e691584df51551
Autor:
Georgina M. Ellison-Hughes, Liam Colley, Katie A. O'Brien, Kirsty A. Roberts, Thomas A. Agbaedeng, Mark D. Ross
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has led to 47 m infected cases and 1. 2 m (2.6%) deaths. A hallmark of more severe cases of SARS-CoV-2 in patients wit
Externí odkaz:
https://doaj.org/article/735d323d9bd04551b1171f54e620df00
Publikováno v:
Life, Vol 12, Iss 3, p 437 (2022)
Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O2) homeostasis, adjusting convective O2 delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of
Externí odkaz:
https://doaj.org/article/a79f616d26214601b6b24978ece3804a
Autor:
Ann Von Holle, Min Shi, Katie M. O'Brien, Clarice R. Weinberg, Dale P. Sandler, Yong-Moon Mark Park
Publikováno v:
Frontiers in Nutrition, Vol 11 (2024)
A better understanding of the factors contributing to systemic concentrations of carotenoids is necessary given the weak correlations between circulating levels and dietary intake of carotenoids. Although genetic variation may play a key role in the
Externí odkaz:
https://doaj.org/article/c0cbb2c9c38243c0bdf8a95b6746b9ef
Autor:
Jie Ping, Guochong Jia, Qiuyin Cai, Xingyi Guo, Ran Tao, Christine Ambrosone, Dezheng Huo, Stefan Ambs, Mollie E. Barnard, Yu Chen, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Esther M. John, Christopher I. Li, Katherine Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Toshio Yoshimatsu, Prisca O. Adejumo, Thomas Ahearn, Abenaa M. Brewster, Anselm J. M. Hennis, Timothy Makumbi, Paul Ndom, Katie M. O’Brien, Andrew F. Olshan, Mojisola M. Oluwasanu, Sonya Reid, Song Yao, Ebonee N. Butler, Maosheng Huang, Atara Ntekim, Bingshan Li, Melissa A. Troester, Julie R. Palmer, Christopher A. Haiman, Jirong Long, Wei Zheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susceptibility genes. We built geneti
Externí odkaz:
https://doaj.org/article/b9834eb3a0344dc2a7b7b629b0f35afc
Autor:
Ann Von Holle, Katie M. O’Brien, Dale P. Sandler, Robert Janicek, Margaret R. Karagas, Alexandra J. White, Nicole M. Niehoff, Keith E. Levine, Brian P. Jackson, Clarice R. Weinberg
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Iron status is often assessed in epidemiologic studies, and toenails offer a convenient alternative to serum because of ease of collection, transport, and storage, and the potential to reflect a longer exposure window. Very few studies have
Externí odkaz:
https://doaj.org/article/3b5e20337020452495c10cb444ec1998
Autor:
Kaitlyn M. Wojcik, Ann Von Holle, Katie M. O'Brien, Alexandra J. White, Margaret R. Karagas, Keith E. Levine, Brian P. Jackson, Clarice R. Weinberg
Publikováno v:
Environmental Advances, Vol 15, Iss , Pp 100496- (2024)
Background: Seasonal patterns in measured exposure biomarkers can cause measurement error in epidemiological studies. There is little research about the seasonality of metals and trace elements when assessed in toenail samples. Adjusting for such pat
Externí odkaz:
https://doaj.org/article/e80b00743b9842538fd6afee03695925
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Serum iron levels can be important contributors to health outcomes, but it is not often feasible to rely on blood-based measures for a large epidemiologic study. Predictive models that use questionnaire-based factors such as diet, supplement
Externí odkaz:
https://doaj.org/article/c9686030f14c42b89e47324d663907b9