Tuft Cells Increase Following Ovine Intestinal Parasite Infections and Define Evolutionarily Conserved and Divergent Responses

Autor: Katie A. Hildersley, Tom N. McNeilly, Victoria Gillan, Thomas D. Otto, Stephan Löser, François Gerbe, Philippe Jay, Rick M. Maizels, Eileen Devaney, Collette Britton

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Helminth parasite infections of humans and livestock are a global health and economic problem. Resistance of helminths to current drug treatment is an increasing problem and alternative control approaches, including vaccines, are needed. Effective va

Externí odkaz: https://doaj.org/article/3d47635cf36f42a0a19214acb01c4e0c

Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens

Autor: Ana Cláudia A. Albuquerque, Cesar Cristiano Bassetto, Fabiana A. Almeida, Katie A. Hildersley, Tom N. McNeilly, Collette Britton, Alessandro F. T. Amarante

Publikováno v: Veterinary Research, Vol 50, Iss 1, Pp 1-12 (2019)

Abstract Understanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The

Externí odkaz: https://doaj.org/article/115bf9e1979e449e95bd04c80866862e

Development of bovine abomasal organoids as a novel in-vitro model to study host-parasite interactions in gastrointestinal nematode infections

Autor: Marc N. Faber, David Smith, Daniel R. G. Price, Philip Steele, Katie A. Hildersley, Liam J. Morrison, Neil A. Mabbott, Alasdair J. Nisbet, Tom N. McNeilly

Publikováno v: Faber, M, Smith, D, Price, D R, Steele, P, Hildersley, K A, Morrison, L, Mabbott, N, Nisbet, A J & McNeilly, T N 2022, ' Development of bovine abomasal organoids as a novel in-vitro model to study host-parasite interactions in gastrointestinal nematode infections ', Frontiers in Cellular and Infection Microbiology, vol. 12, 904606, pp. 1-20 . https://doi.org/10.3389/fcimb.2022.904606

Gastro-intestinal nematode (GIN) parasites are a major cause of production losses in grazing cattle, primarily through reduced growth rates in young animals. Control of these parasites relies heavily on anthelmintic drugs; however, with growing repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8010e32f0f5993658e7982cea614dc15
https://www.pure.ed.ac.uk/ws/files/274842021/904606_Manuscript_2_.PDF