Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Katie A Mitzelfelt"'
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G. Alavattam, Katie A. Mitzelfelt, Giancarlo Bonora, Paul A. Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J. Palpant, William S. Noble, Charles E. Murry
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 159-174 (2023)
Summary: Vascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. The gene-regulatory mechanisms underpinning endothelial specialization are largely unknown, as are the roles of
Externí odkaz:
https://doaj.org/article/5f7f366be7be4a3e89f754bffcd612c1
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 986-998 (2020)
Current cell transplantation techniques are hindered by small graft size, requiring high cell doses to achieve therapeutic cardiac remuscularization. Enhancing the proliferation of transplanted human embryonic stem cell-derived cardiomyocytes (hESC-C
Externí odkaz:
https://doaj.org/article/8e82704e86c448fdbb29b86791afed47
Autor:
Katie A. Mitzelfelt, Chris McDermott-Roe, Michael N. Grzybowski, Maribel Marquez, Chieh-Ti Kuo, Michael Riedel, Shuping Lai, Melinda J. Choi, Kurt D. Kolander, Daniel Helbling, David P. Dimmock, Michele A. Battle, Chuanchau J. Jou, Martin Tristani-Firouzi, James W. Verbsky, Ivor J. Benjamin, Aron M. Geurts
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 491-499 (2017)
Genome editing in induced pluripotent stem cells is currently hampered by the laborious and expensive nature of identifying homology-directed repair (HDR)-modified cells. We present an approach where isolation of cells bearing a selectable, HDR-media
Externí odkaz:
https://doaj.org/article/83b03a2018cb4c5d8fd10a28c1724404
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 986-998 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Current cell transplantation techniques are hindered by small graft size, requiring high cell doses to achieve therapeutic cardiac remuscularization. Enhancing the proliferation of transplanted human embryonic stem cell-derived cardiomyocytes (hESC-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4824a145b0eefcc59b404824a911f2
http://www.sciencedirect.com/science/article/pii/S2329050120300711
http://www.sciencedirect.com/science/article/pii/S2329050120300711
Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation
Autor:
Kris G Alavattam, Katie A Mitzelfelt, Giancarlo Bonora, Paul A Fields, Xiulan Yang, Han Sheng Chiu, Lil Pabon, Alessandro Bertero, Nathan J Palpant, William S Noble, Charles E Murry
BackgroundVascular endothelial cells are a mesoderm-derived lineage with many essential functions, including angiogenesis and coagulation. However, the gene regulatory mechanisms that underpin endothelial specialization are largely unknown, as are th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2f8ec14caa29339d49b582e1ce2bf3
https://hdl.handle.net/2318/1882732
https://hdl.handle.net/2318/1882732
Autor:
Charles E. Murry, Amy M. Martinson, Katie A Mitzelfelt, Sanjay Sinha, Laure Gambardella, L. Ong, Alessandro Bertero, Maria Colzani
Publikováno v:
The Journal of Heart and Lung Transplantation. 40:S299-S300
Purpose Myocardial infarction (MI) results in permanent cardiomyocyte loss, frequently leading to heart failure with 50% 5-year mortality. At subacute time points following MI, animal studies have shown ‘remuscularization’ of the damaged heart wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a8c0991ceee8c31a2f064f002ca9a6f
https://doi.org/10.1016/j.healun.2021.01.849
https://doi.org/10.1016/j.healun.2021.01.849
Autor:
Chieh Ti Kuo, Ivor J. Benjamin, Aron M. Geurts, David Dimmock, Shuping Lai, James W. Verbsky, Katie A. Mitzelfelt, Chuanchau J. Jou, Chris McDermott-Roe, Maribel Marquez, Martin Tristani-Firouzi, Michael Grzybowski, Kurt D. Kolander, Michael Riedel, Michele A. Battle, Daniel Helbling, Melinda J. Choi
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 8, Iss 3, Pp 491-499 (2017)
Stem Cell Reports, Vol 8, Iss 3, Pp 491-499 (2017)
Summary Genome editing in induced pluripotent stem cells is currently hampered by the laborious and expensive nature of identifying homology-directed repair (HDR)-modified cells. We present an approach where isolation of cells bearing a selectable, H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efd6dd7db13b3f2436526f064d01410
Autor:
J. Hudson, Ivor J. Benjamin, Qiang Dai, Justin L. P. Benesch, Elisabeth S. Christians, Rita Barresi, Alex C. Minella, Michael Grzybowski, Kate Bushby, Aron M. Geurts, Pattraranee Limphong, Elizabeth Wraige, Michael Riedel, Heinz Jungbluth, Mai T. Thao, Frances D.L. Kondrat, Shuping Lai, Huali Zhang, Melinda J. Choi, Wai-Meng Kwok, Qiang Lui, Graydon Taylor, Kurt D. Kolander, Katie A. Mitzelfelt
Publikováno v:
Mitzelfelt, K A, Limphong, P, Choi, M J, Kondrat, F D L, Lai, S, Kolander, K D, Kwok, W-M, Dai, Q, Grzybowski, M N, Zhang, H, Taylor, G M, Lui, Q, Thao, M T, Hudson, J A, Barresi, R, Bushby, K, Jungbluth, H, Wraige, E, Geurts, A M, Benesch, J L P, Riedel, M, Christians, E S, Minella, A C & Benjamin, I J 2016, ' Human 343delT HSPB5 Chaperone associated with Early-onset Skeletal Myopathy causes Defects in Protein Solubility ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.M116.730481
Mutations of HSPB5 (also known as CRYAB or αB-crystallin), a bona fide heat shock protein and molecular chaperone encoded by the HSPB5 (crystallin, alpha B) gene, are linked to various multisystem disorders featuring variable combinations of catarac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85b51dad93daa504c4b792be2ca5fe7
https://doi.org/10.1074/jbc.m116.730481
https://doi.org/10.1074/jbc.m116.730481
Autor:
Ivor J. Benjamin, Katie A. Mitzelfelt
Publikováno v:
Heat Shock Proteins ISBN: 9783319160764
αB-Crystallin, or HspB5, is a small molecular-weight heat shock protein expressed highly in cardiac and skeletal muscle with multifaceted cellular roles including, chaperone function towards essential myofibrillar components. Insights into protectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f19acb81143dedbc230937c10b38ae8
https://doi.org/10.1007/978-3-319-16077-1_11
https://doi.org/10.1007/978-3-319-16077-1_11
Autor:
Paul Cheng, Pattraranee Limphong, Dennis R. Winge, Katie A. Mitzelfelt, Elisabeth S. Christians, Deepak Srivastava, Qiang Liu, Huali Zhang, Michael Riedel, Ivor J. Benjamin, Kathryn N. Ivey, Graydon Taylor
Publikováno v:
Stem cells translational medicine, vol 2, iss 3
Limphong, P; Zhang, H; Christians, E; Liu, Q; Riedel, M; Ivey, K; et al.(2013). Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Translational Medicine, 2(3), 161-166. doi: 10.5966/sctm.2012-0073. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5kh5r965
Limphong, P; Zhang, H; Christians, E; Liu, Q; Riedel, M; Ivey, K; et al.(2013). Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Translational Medicine, 2(3), 161-166. doi: 10.5966/sctm.2012-0073. UCSF: Retrieved from: http://www.escholarship.org/uc/item/5kh5r965
Several mutations in αB-crystallin (CryAB), a heat shock protein with chaperone-like activities, are causally linked to skeletal and cardiac myopathies in humans. To better understand the underlying pathogenic mechanisms, we had previously generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038609e5c5b8748ed13820114abfeb5d
https://escholarship.org/uc/item/5kh5r965
https://escholarship.org/uc/item/5kh5r965