Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Katia Scotlandi"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5915 (2024)
Dysregulation of the insulin-like growth factor (IGF) system determines the onset of various pathological conditions, including cancer. Accordingly, therapeutic strategies have been developed to block this system in tumor cells, but the results of cl
Externí odkaz:
https://doaj.org/article/b4da5d08124b4e6fa736b6f4f85322d0
Autor:
Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related tox
Externí odkaz:
https://doaj.org/article/8139d9c37b0e48caa53e1ce404be4871
Autor:
Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Haitao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Isidro Machado, Katia Scotlandi, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, M. Jordan Rowley, Vimla Band, Bhopal C. Mohapatra, Hamid Band
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)
Abstract Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator of intracellular traffic of cell surface receptors plays a role in oncogenesis remains unkn
Externí odkaz:
https://doaj.org/article/09e76c7a25c7457f98d7a6fdc6e884ba
Autor:
Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A detailed characterization of in vitro and in vivo phenotypes of Pfn1 knockout cells demonstrates that loss of this gene results in cytoskeletal alterations, leading to mitotic defects and genome instability.
Externí odkaz:
https://doaj.org/article/8609517adcae44f0a77a5dd393eabeec
Autor:
Lorena Landuzzi, Francesca Ruzzi, Evelin Pellegrini, Pier-Luigi Lollini, Katia Scotlandi, Maria Cristina Manara
Publikováno v:
Cells, Vol 13, Iss 3, p 233 (2024)
IL-1 family members have multiple pleiotropic functions affecting various tissues and cells, including the regulation of the immune response, hematopoietic homeostasis, bone remodeling, neuronal physiology, and synaptic plasticity. Many of these acti
Externí odkaz:
https://doaj.org/article/37e7102f6f0643f9abbda2d0185d716d
Autor:
Alessandra De Feo, Marcello Manfredi, Caterina Mancarella, Joaquín J. Maqueda, Veronica De Giorgis, Ymera Pignochino, Marika Sciandra, Camilla Cristalli, Massimo Donadelli, Katia Scotlandi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1588 (2024)
Ewing sarcoma (EWS) is an aggressive pediatric bone tumor characterized by unmet clinical needs and an incompletely understood epigenetic heterogeneity. Here, we considered CD99, a major surface molecule hallmark of EWS malignancy. Fluctuations in CD
Externí odkaz:
https://doaj.org/article/a3ddf36ea76744fba470bcdda4c382ff
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16346 (2023)
Sarcomas are heterogeneous bone and soft tissue cancers representing the second most common tumor type in children and adolescents. Histology and genetic profiling discovered more than 100 subtypes, which are characterized by peculiar molecular vulne
Externí odkaz:
https://doaj.org/article/7fcd95964b1e4cd684d105558a9aeb61
Autor:
Francesca Chiarini, Francesca Paganelli, Tommaso Balestra, Cristina Capanni, Antonietta Fazio, Maria Cristina Manara, Lorena Landuzzi, Stefania Petrini, Camilla Evangelisti, Pier-Luigi Lollini, Alberto M. Martelli, Giovanna Lattanzi, Katia Scotlandi
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)
Abstract Lamin A, a main constituent of the nuclear lamina, is involved in mechanosignaling and cell migration through dynamic interactions with the LINC complex, formed by the nuclear envelope proteins SUN1, SUN2 and the nesprins. Here, we investiga
Externí odkaz:
https://doaj.org/article/5d5b516d43e64786927cb4086677f8b3
Autor:
Heidi M. Namløs, Magne Skårn, Deeqa Ahmed, Iwona Grad, Kim Andresen, Stine H. Kresse, Else Munthe, Massimo Serra, Katia Scotlandi, Antonio Llombart-Bosch, Ola Myklebost, Guro E. Lind, Leonardo A. Meza-Zepeda
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown to be downregulated i
Externí odkaz:
https://doaj.org/article/b508152fbe6b4d9db3a0cc3f2bf17690
Autor:
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RB1 mutations are seen in 40-60% of sporadic osteosarcoma. Here, the authors demonstrate a selective sensitivity to PARP inhibitors in RB1-mutated osteosarcoma-derived cell lines that is not associated with canonical signatures indicative of a homolo
Externí odkaz:
https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4