Atheroregressive Potential of the Treatment with a Chimeric Monoclonal Antibody against Sulfated Glycosaminoglycans on Pre-existing Lesions in Apolipoprotein E-Deficient Mice

Autor: Victor Brito, Katia Mellal, Karina F. Zoccal, Yosdel Soto, Liliane Ménard, Roger Sarduy, Lucia H. Faccioli, Huy Ong, Ana M. Vázquez, Sylvie Marleau

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation. Administration of chP3R99, a chimeric mouse/human monoclonal antibody inducing an

Externí odkaz: https://doaj.org/article/62e2d75f3c024ff18293a15f1dde3eae

Immunometabolic modulation of retinal inflammation by CD36 ligand

Autor: Yesica Garcia Ramos, Hung Pham, Carl Fortin, Sylvain Chemtob, Houda Tahiri, Simon-Pierre Gravel, Maria Febbraio, Jinqiang Zhang, Katia Mellal, Sheetal Pundir, Florian Sennlaub, Pierre Hardy, Marie-France Dorion, Samy Omri, Jean-François Bouchard, Mukandila Mulumba, Jean-Sébastien Joyal, William D. Lubell, Huy Ong, Sylvie Marleau

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-49472-8⟩

In subretinal inflammation, activated mononuclear phagocytes (MP) play a key role in the progression of retinopathies. Little is known about the mechanism involved in the loss of photoreceptors leading to vision impairment. Studying retinal damage in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf34d08645ea9af4127cbefd244368e
https://hal.sorbonne-universite.fr/hal-02297871/document

Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

Autor: William D. Lubell, Katia Mellal, Huy Ong, Sylvain Chemtob, Lylia Dif-Yaiche, Ramesh Chingle, Samy Omri, Mukandila Mulumba, Stéphane Turcotte

Publikováno v: Biomedicines
Volume 6
Issue 4
Biomedicines, Vol 6, Iss 4, p 98 (2018)

Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8afea974bcaa244d6925cf7f412afc8

Arresting Progression and Promoting Regression of Atherosclerotic Lesions: a Dose-dependent Effect of Active Immunization with an Anti-glycosaminoglycan mAb

Autor: Karina F. Zoccal, Livan Delgado, Sylvie Marleau, Katia Mellal, Victor Brito, Liliane Ménard, Lúcia Helena Faccioli, Huy Ong, Ana María Vázquez, Yosdel Soto, Roger Sarduy

Publikováno v: Atherosclerosis Supplements. 32:7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d0b91c45816b7e133e4ffc5eea0576a
https://doi.org/10.1016/j.atherosclerosissup.2018.04.022

Potential Peptides in Atherosclerosis Therapy

Autor: Sylvie Marleau, Katia Mellal, David N. Huynh, Huy Ong

Atherosclerosis is the main underlying cause of ischemic heart disease and related acute cardiovascular complications, including myocardial infarction and stroke. In view of the failure of statins to demonstrate a beneficial effect in all patients, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb59c842d624774627fa62a0fd07e9c2
https://doi.org/10.1159/000360568