Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Katia J. Evans"'
Autor:
Christian W. Keller, Bryan Conn, Brett Lauring, Kristen Glasgow, Karen S. Pavur, Katia J. Evans
Publikováno v:
Proceedings of the National Academy of Sciences. 103:10666-10671
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder that is characterized by retrograde axonal degeneration that primarily affects long spinal neurons. The disease is clinically heterogeneous, and there are >20 genetic loci identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1adf6a14ddfd73a216123fcf74584d87
https://doi.org/10.1073/pnas.0510863103
https://doi.org/10.1073/pnas.0510863103
Publikováno v:
The Journal of Cell Biology
Mutations in the AAA adenosine triphosphatase (ATPase) Spastin (SPG4) cause an autosomal dominant form of hereditary spastic paraplegia, which is a retrograde axonopathy primarily characterized pathologically by the degeneration of long spinal neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4806a357f11494b5eb879f6b6803d3cc
http://europepmc.org/articles/PMC2171748
http://europepmc.org/articles/PMC2171748
Publikováno v:
The Journal of Cell Biology
Spastin, an AAA ATPase mutated in the neurodegenerative disease hereditary spastic paraplegia, severs microtubules. Many other AAA proteins form ring-shaped hexamers and contain pore loops, which project into the ring's central cavity and act as ratc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9080b540e31888fbbe790d2b07c9a2
https://pubmed.ncbi.nlm.nih.gov/17389232
https://pubmed.ncbi.nlm.nih.gov/17389232
Publikováno v:
Journal of Neuropathology & Experimental Neurology; Jan2007, Vol. 66 Issue 1, p98-98, 1p