Designed Glycopeptidomimetics Disrupt Protein–Protein Interactions Mediating Amyloid β-Peptide Aggregation and Restore Neuroblastoma Cell Viability

Autor: Katia Fabiana Fera, Olivier Lequin, David Allsop, Jean-Louis Soulier, Benoit Crousse, Nicolo Tonali, Dimitri Brinet, Mark Taylor, Lucie Khemtémourian, Isabelle Correia, Anais R. F. Hoffmann, Sandrine Ongeri, Yasmine Iacone, Julia Kaffy, Myriam Taverna

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (5), pp.2025-2040. 〈10.1021/acs.jmedchem.5b01629〉
Journal of Medicinal Chemistry, 2016, 59 (5), pp.2025-2040. ⟨10.1021/acs.jmedchem.5b01629⟩

International audience; How anti-Alzheimer’s drug candidates that reduce amyloid 1–42 peptide fibrillization interact with the most neurotoxic species is far from being understood. We report herein the capacity of sugar-based peptidomimetics to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f19a813c4432451068411b21bbe840
https://hal.archives-ouvertes.fr/hal-01303733