Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katia De Filippo"'
Autor:
Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjortø, Sara Rankin, Jon Våbenø, Mette M. Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally p
Externí odkaz:
https://doaj.org/article/d920693ad8d842c78b29bd1b15141947
Autor:
Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi, John B. G. Mackey, Charlotte Dean, James A. Harker, Leo M. Carlin, Sara Rankin, Katia De Filippo
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights
Externí odkaz:
https://doaj.org/article/67efe035c82742a48b93c25118ed42a5
Autor:
Katia De Filippo, Sara M. Rankin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Neutrophils are the most abundant circulating leukocyte within the blood stream and for many years the dogma has been that these cells migrate rapidly into tissues in response to injury or infection, forming the first line of host defense. While it h
Externí odkaz:
https://doaj.org/article/a053d6fdb4eb4973959384a96b3b0fec
Autor:
Thomas Jamieson, Ximena L. Raffo-Iraolagoitia, Sergio Lilla, Judith Secklehner, Thomas G. Bird, Daniel J. Murphy, John B. G. Mackey, Colin W. Steele, Gerard J. Graham, Amanda J. McFarlane, William T. Clarke, Leo M. Carlin, Juho Vuononvirta, Rene Jackstadt, Xabier Cortes-Lavaud, Sara Zanivan, Jim C. Norman, Frédéric Fercoq, Owen J. Sansom, Jennifer P. Morton, Katia De Filippo, Ann Hedley, Derek A. Mann, Kathryn Gilroy
Neutrophils have been implicated in poor outcomes in cancer and severe inflammation. We found that neutrophils expressing intermediate levels of Ly6G (Ly6GInt) were present in mouse cancer models and more abundant in those with high rates of spontane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a66015606ee0417065999bdd5a17324e
https://doi.org/10.1101/2021.07.21.453108
https://doi.org/10.1101/2021.07.21.453108
Autor:
Sara M. Rankin, Viktorija Daugvilaite, Katia De Filippo, Goda Juzenaite, Astrid Sissel Jørgensen, Mette M. Rosenkilde, Maša Mavri, Christian Berg, Tau Benned-Jensen, Gertrud Malene Hjortø, Jon Våbenø
Publikováno v:
Communications Biology
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85e58203949fdd2febe45ee002aba4
http://hdl.handle.net/10044/1/88841
http://hdl.handle.net/10044/1/88841
Autor:
Sara M. Rankin, Katia De Filippo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Neutrophils are the most abundant circulating leukocyte within the blood stream and for many years the dogma has been that these cells migrate rapidly into tissues in response to injury or infection, forming the first line of host defense. While it h
Autor:
Goda, Juzenaite, Judith, Secklehner, Juho, Vuononvirta, Yoseph, Helbawi, John B G, Mackey, Charlotte, Dean, James A, Harker, Leo M, Carlin, Sara, Rankin, Katia, De Filippo
Publikováno v:
Frontiers in Immunology
The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights
Autor:
Janesh Pillay, Leo M. Carlin, Sara M. Rankin, David C. A. Gaboriau, Chiara Pirillo, Nicola Tregay, Edwin R. Chilvers, Charlotte Summers, Goda Juzenaite, Neda Farahi, Cristina Lo Celso, Katia De Filippo
Publikováno v:
Journal of Leukocyte Biology, 107(6), 1175-1185. FEDERATION AMER SOC EXP BIOL
Treatment with the CXCR4 antagonist, plerixafor (AMD3100), has been proposed for clinical use in patients with WHIM (warts, hypogammaglobulinemia, infections and myelokathexis) syndrome and in pulmonary fibrosis. However, there is controversy with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e35c5949824c3559f1f4314469969c
https://www.repository.cam.ac.uk/handle/1810/304768
https://www.repository.cam.ac.uk/handle/1810/304768
Autor:
Sara M. Rankin, Katia De Filippo
Publikováno v:
European Journal of Clinical Investigation
Background Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. Results The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. Conclusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9742a9ba362de101c7d2d6e2c516827d
http://hdl.handle.net/10044/1/60340
http://hdl.handle.net/10044/1/60340
Autor:
Katia De Filippo, Meg Mathies, Aras Kadioglu, Nancy Hogg, Eileen McNeill, Mathieu Bangert, Daniel R. Neill
Publikováno v:
The FASEB Journal. 28:3600-3608
The S100A8/A9 heterodimer is abundantly expressed by myeloid cells, especially neutrophils, but its mechanism of action is only partially determined. In this study we investigated S100A8/A9 involvement in the host response to Streptococcus pneumoniae