Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Katia, Scotlandi"'
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1306 (2024)
Pediatric sarcomas present a significant challenge in oncology. There is an urgent need for improved therapeutic strategies for high-risk patients and better management of long-term side effects for those who survive the disease. Liquid biopsy is eme
Externí odkaz:
https://doaj.org/article/09e36ea094b6488e9b3de96ff8ef858f
Autor:
Sara Salucci, Alberto Bavelloni, Ilaria Versari, Sabrina Burattini, Francesco Bavelloni, Pietro Gobbi, Alessandro Fanzani, Silvia Codenotti, William Blalock, Katia Scotlandi, Irene Faenza
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1180 (2024)
Rhabdomyosarcoma (RMS), the most common form of sarcoma typical of pediatric age, arises from the malignant transformation of the mesenchymal precursors that fail to differentiate into skeletal muscle cells. Here, we investigated whether the protein
Externí odkaz:
https://doaj.org/article/3f27de51a5ce437fa12ac8451df1caf7
Autor:
Camilla Cristalli, Katia Scotlandi
Publikováno v:
Cells, Vol 13, Iss 14, p 1209 (2024)
DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a variety of cellular processes, including the regulation of cell fate during development, maintenance of cell identity, and genome stability. DNA methylation is t
Externí odkaz:
https://doaj.org/article/ed9eb99892be4769b61f1a157ffeb672
Autor:
Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Haitao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Isidro Machado, Katia Scotlandi, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, M. Jordan Rowley, Vimla Band, Bhopal C. Mohapatra, Hamid Band
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-21 (2023)
Abstract Overexpression of the EPS15 Homology Domain containing 1 (EHD1) protein has been linked to tumorigenesis but whether its core function as a regulator of intracellular traffic of cell surface receptors plays a role in oncogenesis remains unkn
Externí odkaz:
https://doaj.org/article/09e76c7a25c7457f98d7a6fdc6e884ba
Autor:
Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related tox
Externí odkaz:
https://doaj.org/article/8139d9c37b0e48caa53e1ce404be4871
Autor:
Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortés-Ciriano, Fernando Gianfrancesco
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A detailed characterization of in vitro and in vivo phenotypes of Pfn1 knockout cells demonstrates that loss of this gene results in cytoskeletal alterations, leading to mitotic defects and genome instability.
Externí odkaz:
https://doaj.org/article/8609517adcae44f0a77a5dd393eabeec
Autor:
Lorena Landuzzi, Francesca Ruzzi, Evelin Pellegrini, Pier-Luigi Lollini, Katia Scotlandi, Maria Cristina Manara
Publikováno v:
Cells, Vol 13, Iss 3, p 233 (2024)
IL-1 family members have multiple pleiotropic functions affecting various tissues and cells, including the regulation of the immune response, hematopoietic homeostasis, bone remodeling, neuronal physiology, and synaptic plasticity. Many of these acti
Externí odkaz:
https://doaj.org/article/37e7102f6f0643f9abbda2d0185d716d
Autor:
Francesca Chiarini, Francesca Paganelli, Tommaso Balestra, Cristina Capanni, Antonietta Fazio, Maria Cristina Manara, Lorena Landuzzi, Stefania Petrini, Camilla Evangelisti, Pier-Luigi Lollini, Alberto M. Martelli, Giovanna Lattanzi, Katia Scotlandi
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)
Abstract Lamin A, a main constituent of the nuclear lamina, is involved in mechanosignaling and cell migration through dynamic interactions with the LINC complex, formed by the nuclear envelope proteins SUN1, SUN2 and the nesprins. Here, we investiga
Externí odkaz:
https://doaj.org/article/5d5b516d43e64786927cb4086677f8b3
Autor:
Heidi M. Namløs, Magne Skårn, Deeqa Ahmed, Iwona Grad, Kim Andresen, Stine H. Kresse, Else Munthe, Massimo Serra, Katia Scotlandi, Antonio Llombart-Bosch, Ola Myklebost, Guro E. Lind, Leonardo A. Meza-Zepeda
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown to be downregulated i
Externí odkaz:
https://doaj.org/article/b508152fbe6b4d9db3a0cc3f2bf17690
Autor:
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RB1 mutations are seen in 40-60% of sporadic osteosarcoma. Here, the authors demonstrate a selective sensitivity to PARP inhibitors in RB1-mutated osteosarcoma-derived cell lines that is not associated with canonical signatures indicative of a homolo
Externí odkaz:
https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4