Výsledky vyhledávání - "Kati Takaluoma"

Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences

Autor: Juha Lantto, Kati Takaluoma, Johanna Myllyharju

Publikováno v: Matrix Biology. 26:396-403

Lysyl hydroxylase (LH), with three isoenzymes in vertebrates, catalyzes the formation of hydroxylysine by acting on -X-Lys-Gly- triplets in the collagenous domains of proteins of the collagen superfamily and also in -X-Lys-Ala- or -X-Lys-Ser- sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da73f76402e5ac16a71957e4741046ca
https://doi.org/10.1016/j.matbio.2007.01.002

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Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice

Autor: Johanna Myllyharju, Raija Soininen, Ruud A. Bank, Marjo Hyry, Kati Takaluoma, Raija Sormunen, Juha Lantto, Kari I. Kivirikko

Publikováno v: The Journal of Biological Chemistry, 282, 6588-6596. American Society for Biochemistry and Molecular Biology Inc.
Takaluoma, K, Hyry, M, Lantto, J, Sormunen, R, Bank, R A, Kivirikko, K I, Myllyharja, J & Soininen, R 2007, ' Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice ', The Journal of Biological Chemistry, vol. 282, pp. 6588-6596 . https://doi.org/10.1074/jbc.M608830200

We have generated mice with targeted inactivation of the Plod1 gene for lysyl hydroxylase 1 (LH1). Its human mutations cause Ehlers-Danlos syndrome VIA (EDS VIA) characterized by muscular hypotonia, joint laxity, and kyphoscoliosis. The Plod1(-/-) mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e149613c36654917e5fdaf937f53d832
https://hdl.handle.net/11245/1.277700

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p38 Mitogen-activated Protein Kinase Regulates Interleukin-4-induced Gene Expression by Stimulating STAT6-mediated Transcription

Autor: Marko Pesu, Olli Silvennoinen, Anssi Lagerstedt, Saara Aittomäki, Kati Takaluoma

Publikováno v: Journal of Biological Chemistry. 277:38254-38261

STAT6 functions as a critical mediator of IL-4-stimulated gene activation, and the function of STAT6 is regulated by both tyrosine and serine kinase activities. Here we analyzed the role of serine phosphorylation in regulation of STAT6-mediated trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9180ef12421bce0c07b7ea95f57476
https://doi.org/10.1074/jbc.m201427200

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Characterization of Three Fragments That Constitute the Monomers of the Human Lysyl Hydroxylase Isoenzymes 1–3

Autor: Kati Rautavuoma, Johanna Myllyharju, Asta Pirskanen, Kaisa Passoja, Kati Takaluoma, Ari-Pekka Kvist, Kari I. Kivirikko

Publikováno v: Journal of Biological Chemistry. 277:23084-23091

Lysyl hydroxylase (LH) catalyzes the formation of hydroxylysine in collagens; three human isoenzymes have been cloned so far. We report here on the purification of all three recombinant isoenzymes to homogeneity from the medium of cultured insect cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05ef913587da75357a6c1e4fa976a113
https://doi.org/10.1074/jbc.m112077200

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Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3–dependent myeloid progenitor cells

Autor: Leena Valmu, Pipsa Saharinen, Ilkka Junttila, Olli Silvennoinen, Panu E. Kovanen, Kati Takaluoma, Weiqun Li

Publikováno v: ResearcherID
Scopus-Elsevier

Differentiation of macrophages from myeloid progenitor cells depends on a discrete balance between cell growth, survival, and differentiation signals. Interleukin-3 (IL-3) supports the growth and survival of myeloid progenitor cells through the activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7a7bdc654de0d8dd8b4b03308cf1b7
https://doi.org/10.1182/blood.v95.5.1626.005k21_1626_1632

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Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors

Autor: Pipsa Saharinen, Kirsi Paukku, Panu E. Kovanen, Kati Takaluoma, Olli Silvennoinen

Publikováno v: ResearcherID

Cytokines are the principal regulators of cell proliferation and differentiation of hematopoietic cells and these responses are initiated through activation of hematopoietic cytokine receptors. Although the receptor intracellular domains lack any kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f5bfe628b16a64e2c86caa836e8697
https://doi.org/10.1111/j.1699-0463.1997.tb05047.x

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Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6

Autor: Saara Aittomäki, Olli Silvennoinen, Kalle Saksela, Anssi Lagerstedt, Panu E. Kovanen, Kati Takaluoma, Marko Pesu

Publikováno v: Scopus-Elsevier

Stat6 transcription factor is a critical mediator of IL-4-specific gene responses. Tyrosine phosphorylation is required for nuclear localization and DNA binding of Stat6. The authors investigated whether Stat6-dependent transcriptional responses are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c15760d462b115634fe990ab070d81
http://www.scopus.com/inward/record.url?eid=2-s2.0-0034650951&partnerID=MN8TOARS

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