Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Kathy Steece-Collier"'
Autor:
Natosha M. Mercado, Carlye Szarowicz, Jennifer A. Stancati, Caryl E. Sortwell, Samuel A. Boezwinkle, Timothy J. Collier, Margaret E. Caulfield, Kathy Steece-Collier
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract The rs6265 single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor is a common variant that alters therapeutic outcomes for individuals with Parkinson’s disease (PD). We previously investigated the effects of
Externí odkaz:
https://doaj.org/article/04243b627f4647388bacb505772446ee
Autor:
Joseph R. Patterson, Joseph Kochmanski, Anna C. Stoll, Michael Kubik, Christopher J. Kemp, Megan F. Duffy, Kajene Thompson, Jacob W. Howe, Allyson Cole-Strauss, Nathan C. Kuhn, Kathryn M. Miller, Seth Nelson, Christopher U. Onyekpe, John S. Beck, Scott E. Counts, Alison I. Bernstein, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-syn
Externí odkaz:
https://doaj.org/article/8bde4016617e4debb09532f2fc4a2cc0
Autor:
Anna C. Stoll, Christopher J. Kemp, Joseph R. Patterson, Jacob W. Howe, Kathy Steece-Collier, Kelvin C. Luk, Caryl E. Sortwell, Matthew J. Benskey
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106411- (2024)
Parkinson's disease (PD) pathology is characterized by alpha-synuclein (α-syn) aggregates, degeneration of dopamine neurons in the substantia nigra pars compacta (SNpc), and neuroinflammation. The presence of reactive glia correlates with deposition
Externí odkaz:
https://doaj.org/article/f5390f22412347b4b85630400c80d5a3
Autor:
Margaret E. Caulfield, Molly J. Vander Werp, Jennifer A. Stancati, Timothy J. Collier, Caryl E. Sortwell, Ivette M. Sandoval, Fredric P. Manfredsson, Kathy Steece-Collier
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106111- (2023)
In the past 25 years, the prevalence of Parkinson's disease (PD) has nearly doubled. Age remains the primary risk factor for PD and as the global aging population increases this trend is predicted to continue. Even when treated with levodopa, the gol
Externí odkaz:
https://doaj.org/article/0a32cba2dcf34119b5bce4aa489fc00e
Autor:
Joseph R. Patterson, Warren D. Hirst, Jacob W. Howe, Christopher P. Russell, Allyson Cole-Strauss, Christopher J. Kemp, Megan F. Duffy, Jared Lamp, Andrew Umstead, Michael Kubik, Anna C. Stoll, Irving E. Vega, Kathy Steece-Collier, Yi Chen, Anne C. Campbell, Catherine L. Nezich, Kelly E. Glajch, Caryl E. Sortwell
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract β2-adrenoreceptor (β2AR) agonists have been associated with a decreased risk of developing Parkinson’s disease (PD) and are hypothesized to decrease expression of both alpha-synuclein mRNA (Snca) and protein (α-syn). Effects of β2AR ag
Externí odkaz:
https://doaj.org/article/1490e19ae927454fbbfea97a835eff52
Autor:
Danish M Anwer, Francesco Gubinelli, Yunus A Kurt, Livija Sarauskyte, Febe Jacobs, Chiara Venuti, Ivette M Sandoval, Yiyi Yang, Jennifer Stancati, Martina Mazzocchi, Edoardo Brandi, Gerard O'Keeffe, Kathy Steece-Collier, Jia-Yi Li, Tomas Deierborg, Fredric P Manfredsson, Marcus Davidsson, Andreas Heuer
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0284480 (2023)
Microglial cells are brain-specific macrophages that swiftly react to disruptive events in the brain. Microglial activation leads to specific modifications, including proliferation, morphological changes, migration to the site of insult, and changes
Externí odkaz:
https://doaj.org/article/fcdfb7538fd1416cbc6c38dd6c8d0c4e
Autor:
Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop, Fredric P. Manfredsson
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Levodopa-induced dyskinesias (LID) are a prevalent side effect of chronic treatment with levodopa (L-DOPA) for the motor symptoms of Parkinson’s disease (PD). It has long been hypothesized that serotonergic neurons of the dorsal raphe nucl
Externí odkaz:
https://doaj.org/article/e3d5337e194b46f3a19e621ec823fa0b
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 8011 (2022)
Brain-derived neurotrophic factor is an extensively studied neurotrophin implicated in the pathology of multiple neurodegenerative and psychiatric disorders including, but not limited to, Parkinson’s disease, Alzheimer’s disease, Huntington’s d
Externí odkaz:
https://doaj.org/article/b0b88e3d28ea41d2960ca2839e0bdb02
Autor:
Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, Katrina L. Paumier
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Externí odkaz:
https://doaj.org/article/d06ea6f3c76f4b97a20be199ac938389
Autor:
Natosha M. Mercado, Jennifer A. Stancati, Caryl E. Sortwell, Rebecca L. Mueller, Samuel A. Boezwinkle, Megan F. Duffy, D. Luke Fischer, Ivette M. Sandoval, Fredric P. Manfredsson, Timothy J. Collier, Kathy Steece-Collier
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105175- (2021)
Prevalent in approximately 20% of the worldwide human population, the rs6265 (also called ‘Val66Met’) single nucleotide polymorphism (SNP) in the gene for brain-derived neurotrophic factor (BDNF) is a common genetic variant that can alter therape
Externí odkaz:
https://doaj.org/article/db10f0cf24c5467a89a08574d6b5d9db