Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kathy Senekeo-Effenberger"'
Publikováno v:
Xenobiotica. 39:826-835
A transgenic 'knock-in' mouse model expressing a human UGT1 locus (Tg-UGT1) was recently developed and validated. Although these animals express mouse UGT1A proteins, UGT1A4 is a pseudo-gene in mice. Therefore, Tg-UGT1 mice serve as a 'humanized' UGT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c92da81a2ddc436080608b6da1a8cd0
https://doi.org/10.3109/00498250903188985
https://doi.org/10.3109/00498250903188985
Autor:
Olivier Barbier, Jocelyn Trottier, Julie Bélanger, Jessica A. Bonzo, Bart Staels, Kathy Senekeo-Effenberger, Mélanie Verreault, Jenny Kaeding, Patrick Caron, Robert H. Tukey
Publikováno v:
Hepatology. 44:368-378
Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is considered the major human enzyme for the hepatic C24-glucuronidation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55717639c8352140529c8363b972f6c
https://doi.org/10.1002/hep.21259
https://doi.org/10.1002/hep.21259
Autor:
Kathy Senekeo-Effenberger, Robert H. Tukey, Nghia Nguyen, Jocelyn Trottier, Olivier Barbier, Shujuan Chen, Deirdre Beaton, Rory P. Remmel, Joseph K. Ritter, Upendra A. Argikar, Erin Brace-Sinnokrak
Publikováno v:
Journal of Biological Chemistry. 280:37547-37557
The human UDP-glucuronosyltransferase 1 (UGT1) locus spans nearly 200 kb on chromosome 2 and encodes nine UGT1A proteins that play a prominent role in drug and xenobiotic metabolism. Transgenic UGT1 (Tg-UGT1) mice have been created, and it has been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a89ddf9889e898ed0884f984bddbd5c
https://doi.org/10.1074/jbc.m506683200
https://doi.org/10.1074/jbc.m506683200
Autor:
Kathy Senekeo-Effenberger, Thomas G. Nolan, David C. Griffith, Courtney E. Miller, Michael N. Dudley, Mojgan Sabet
Publikováno v:
Antimicrobial agents and chemotherapy. 53(9)
Progressive respiratory failure due toPseudomonas aeruginosais the leading cause of morbidity and mortality in patients with cystic fibrosis. The pulmonary delivery of antimicrobial agents provides high concentrations of drug directly to the site of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc9de1a78c702a1ae48bff162e504bf
https://pubmed.ncbi.nlm.nih.gov/19528273
https://pubmed.ncbi.nlm.nih.gov/19528273
Autor:
Jessica A. Bonzo, Robert H. Tukey, Jenny Kaeding, M-F. Yueh, Joseph K. Ritter, Erin Brace-Sinnokrak, Olivier Barbier, Shujuan Chen, Rory P. Remmel, Kathy Senekeo-Effenberger, Jocelyn Trottier, Upendra A. Argikar
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8bfbd66f4980e075adb62313d0a564
https://doi.org/10.1096/fasebj.22.1_supplement.184.1
https://doi.org/10.1096/fasebj.22.1_supplement.184.1
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c1e7572cff24ced4b0670f7f13d616b
https://doi.org/10.1096/fasebj.21.6.lb78-a
https://doi.org/10.1096/fasebj.21.6.lb78-a
Autor:
Shujuan Chen, Rory P. Remmel, Upendra A. Argikar, Jessica A. Bonzo, Jocelyn Trottier, Joseph K. Ritter, Robert H. Tukey, Mei-Fei Yueh, Jenny Kaeding, Erin Brace-Sinnokrak, Kathy Senekeo-Effenberger, Olivier Barbier
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(3)
The UDP-glucuronosyltransferase (UGT) 1A genes in humans have been shown to be differentially regulated in a tissue-specific fashion. Transgenic mice carrying the human UGT1 locus (Tg-UGT1) were recently created, demonstrating that expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae4e5dc07f228922ea775100e0fce11
https://pubmed.ncbi.nlm.nih.gov/17151188
https://pubmed.ncbi.nlm.nih.gov/17151188
Publikováno v:
The FASEB Journal. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd35f7e214fa6a7603d51b7a140c4d45
https://doi.org/10.1096/fasebj.20.4.a265
https://doi.org/10.1096/fasebj.20.4.a265