Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Kathy Q Cai"'
Publikováno v:
Biomarker Research, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the lo
Externí odkaz:
https://doaj.org/article/c8363ce9a6174b14b090a91424f6ba24
Autor:
Jeremy G T Wurtzel, Sophia Lazar, Sonali Sikder, Kathy Q Cai, Igor Astsaturov, Andrew S Weyrich, Jesse W Rowley, Lawrence E Goldfinger
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261633 (2021)
We investigated the contributions of platelet microRNAs (miRNAs) to the rate of growth and regulation of gene expression in primary ectopic tumors using mouse models. We previously identified an inhibitory role for platelets in solid tumor growth, me
Externí odkaz:
https://doaj.org/article/564d84e427ae4392946adcf269f598e9
Autor:
Shuyun Rao, Suraj Peri, Jens Hoffmann, Kathy Q Cai, Bryan Harris, Michele Rhodes, Denise C Connolly, Joseph R Testa, David L Wiest
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222392 (2019)
We have previously demonstrated that loss of the tumor suppressive activity of ribosomal protein (RP) RPL22 predisposes to development of leukemia in mouse models and aggressive disease in human patients; however, the role of RPL22 in solid tumors, s
Externí odkaz:
https://doaj.org/article/a159016e8ae7439f943b54efe9cd555c
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Dana Pape-Zambito, Zhengyu Jiang, Hong Wu, Karthik Devarajan, Carolyn M Slater, Kathy Q Cai, Arthur Patchefsky, Mary B Daly, Xiaowei Chen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100488 (2014)
The heterogeneity among multiple ductal carcinoma in situ (DCIS) lesions within the same patient also diagnosed with invasive ductal carcinoma (IDC) has not been well evaluated, leaving research implications of intra-individual DCIS heterogeneity yet
Externí odkaz:
https://doaj.org/article/cf46ecc989014c7eb753319216f40d81
Autor:
Zachary B Smithline, Anna S Nikonova, Harvey H Hensley, Kathy Q Cai, Brian L Egleston, David A Proia, Tamina Seeger-Nukpezah, Erica A Golemis
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114403 (2014)
Polycystic liver disease (PLD) occurs in 75-90% of patients affected by autosomal dominant polycystic kidney disease (ADPKD), which affects 1∶400-1,000 adults and arises from inherited mutations in the PKD1 or PKD2 genes. PLD can lead to bile duct
Externí odkaz:
https://doaj.org/article/a4f194c1dcda4db6b40704fc2c76dd2c
Publikováno v:
Cells, Vol 13, Iss 9, p 787 (2024)
IL-36 cytokines are emerging as beneficial in immunity against pathogens and cancers but can also be detrimental when dysregulated in autoimmune and autoinflammatory conditions. Interest in targeting IL-36 activity for therapeutic purposes is rapidly
Externí odkaz:
https://doaj.org/article/e93482263f9f44c58c47217b1d93913a
Autor:
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T. Frederick, Genevieve M. Boland, Guangcan Shao, Tatyana M. Svitkina, Kathy Q. Cai, Fangping Chen, Meng-Qiu Dong, Gordon B. Mills, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Mitchell, Keith T. Flaherty, David W. Speicher, Youhai H. Chen, Meenhard Herlyn, Ravi K. Amaravadi, Xiaowei Xu, Wei Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lack of CD8+ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promot
Externí odkaz:
https://doaj.org/article/718e304323ab40bb82fc54fc7895e125
Autor:
Peter Makhov, Rushaniya Fazliyeva, Antonio Tufano, Robert G. Uzzo, Kathy Q. Cai, Ilya Serebriiskii, Nathaniel W. Snyder, Andrew J. Andrews, Vladimir M. Kolenko
Publikováno v:
Cancers, Vol 14, Iss 23, p 5900 (2022)
The commonly used therapeutic management of PC involves androgen deprivation therapy (ADT) followed by treatment with AR signaling inhibitors (ARSI). However, nearly all patients develop drug-resistant disease, with a median progression-free survival
Externí odkaz:
https://doaj.org/article/cc0e56e8a129427ba55c1260f0b7d576
Autor:
Vinay Jain, Divyashri Baraniya, Doaa E. El-Hadedy, Tsute Chen, Michael Slifker, Fadhl Alakwaa, Kathy Q. Cai, Kumaraswamy N. Chitrala, Christopher Fundakowski, Nezar N. Al-Hebshi
Publikováno v:
Cancer Research Communications. 3:807-820
Studies on the microbiome of oral squamous cell carcinoma (OSCC) have been limited to 16S rRNA gene sequencing. Here, laser microdissection coupled with brute-force, deep metatranscriptome sequencing was employed to simultaneously characterize the mi