Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kathy Nga-Chu Lui"'
Autor:
Zhixin Li, Kathy Nga-Chu Lui, Sin-Ting Lau, Frank Pui-Ling Lai, Peng Li, Patrick Ho-Yu Chung, Kenneth Kak-Yuen Wong, Paul Kwong-Hing Tam, Maria-Mercedes Garica-Barcelo, Chi-Chung Hui, Pak Chung Sham, Elly Sau-Wai Ngan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hirschsprung disease is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells, leading to intestinal obstruction. Here, using induced pluripotent stem cell-based models of Hirschsprung and single
Externí odkaz:
https://doaj.org/article/900f75b8630e4433832db65c3d9cbb22
Autor:
Kathy Nga-Chu Lui, Elly Sau-Wai NGAN
Publikováno v:
Cells, Vol 11, Iss 21, p 3428 (2022)
Hirschsprung disease (HSCR) is a complex congenital disorder caused by defects in the development of the enteric nervous system (ENS). It is attributed to failures of the enteric neural crest stem cells (ENCCs) to proliferate, differentiate and/or mi
Externí odkaz:
https://doaj.org/article/6ea34aecb45e4e5e984e10dc3edbdb50
Autor:
Zhixin Li, Kathy Nga-Chu Lui, Sin-Ting Lau, Frank Pui-Ling Lai, Peng Li, Patrick CHUNG, Kenneth Wong, Paul TAM, Maria-Mercè Gracia-Barcelo, Chi-chung Hui, Pak Sham, Elly Ngan
Hirschsprung disease (HSCR) is characterized by the absence of enteric neurons caused by the defects of enteric neural crest cells (ENCCs), leading to intestinal obstruction. Here, using iPSC-based models of HSCR and single-cell transcriptomic analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cd6099050ce2fa05eb2c9671b02d1b
https://doi.org/10.21203/rs.3.rs-1433241/v1
https://doi.org/10.21203/rs.3.rs-1433241/v1
Autor:
Alexander Xi Fu, Kathy Nga-Chu Lui, Kevin Y. Yip, Elly Sau-Wai Ngan, Sin-Ting Lau, Clara S. Tang, Zhixin Li, Paul K.H. Tam, Maria-Mercè Gracia-Barcelo, Ray Kit Ng, Pak C. Sham, Frank Pui-Ling Lai
It is widely recognized that the missing heritability of many human diseases is partially due to noncoding genetic variants, but there are multiple challenges that hinder the identification of functional disease-associated noncoding variants. The num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991ded6fc798442b7cdc2c7bacab56f1
https://doi.org/10.1101/2020.04.08.032045
https://doi.org/10.1101/2020.04.08.032045
Autor:
Zhixin Li, Frank Pui-Ling Lai, Alexander Xi Fu, Paul K.H. Tam, Sin-Ting Lau, Kevin Y. Yip, Kathy Nga-Chu Lui, Pak C. Sham, Ray Kit Ng, Elly Sau-Wai Ngan, Clara S. Tang, Maria-Mercè Garcia-Barceló
Publikováno v:
Genome Res
It is widely recognized that noncoding genetic variants play important roles in many human diseases, but there are multiple challenges that hinder the identification of functional disease-associated noncoding variants. The number of noncoding variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a9e90243685b29941cd2646810df1e
https://pubmed.ncbi.nlm.nih.gov/32948616
https://pubmed.ncbi.nlm.nih.gov/32948616
Publikováno v:
European Journal of Pediatric Surgery. 28:215-221
Stem cells possess the ability of self-renewal and the potency to differentiate into multiple cell lineages. Somatic stem cells are present in adult tissues, but they usually exhibit limited differentiation capacity and life span. On the other hand,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e9bd1f835b12b70d2b7fc7fd69c4b9
https://doi.org/10.1055/s-0038-1646925
https://doi.org/10.1055/s-0038-1646925
Autor:
James M. Wells, Zhixin Li, Guangjin Pan, Sin-Ting Lau, Maxime M. Mahe, Elly Sau-Wai Ngan, Kathy Nga-Chu Lui, Jorge O. Múnera, Chi-chung Hui, Peng Li, Frank Pui-Ling Lai
Publikováno v:
Gastroenterology. 157(6)
Background & Aims It has been a challenge to develop fully functioning cells from human pluripotent stem cells (hPSCs). We investigated how activation of hedgehog signaling regulates derivation of enteric neural crest (NC) cells from hPSCs. Methods W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e03dc6d379ba0611eb86ca59f7b030
https://pubmed.ncbi.nlm.nih.gov/31442438
https://pubmed.ncbi.nlm.nih.gov/31442438
Autor:
Zhixin Li, Hualong Wang, Paul Kwang-Hang Tam, Peng Li, Hong Liu, Xuehan Zhuang, Zhen-wei Yuan, Bin Yi, Michelle Yu, Maria-Mercè Garcia-Barceló, Xuelai Liu, Pak C. Sham, Elly Sau-Wai Ngan, Frank Pui-Ling Lai, Clara S. Tang, Kevin Y. Yip, Xi Zhang, Kathryn S. E. Cheah, Ngoc Diem Ngo, Qiji Liu, Furen Zhang, Sin-Ting Lau, Xiao-bing Sun, Xiaoping Miao, Shao-tao Tang, Ruizhong Zhang, Alexander Xi Fu, Liu-ming Huang, Kathy Nga-Chu Lui, Wanling Yang, Man-Ting So, Jin-fa Tou, Xiao Dong
Publikováno v:
Gastroenterology. 155:1908-1922.e5
Background & Aims Hirschsprung disease, or congenital aganglionosis, is believed to be oligogenic—that is, caused by multiple genetic factors. We performed whole-genome sequence analyses of patients with Hirschsprung disease to identify genetic fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f091bb02531503126092385ee517da9e
https://doi.org/10.1053/j.gastro.2018.09.012
https://doi.org/10.1053/j.gastro.2018.09.012
Autor:
Lui, Kathy Nga-Chu1 (AUTHOR), NGAN, Elly Sau-Wai1 (AUTHOR) engan@hku.hk
Publikováno v:
Cells (2073-4409). Nov2022, Vol. 11 Issue 21, p3428. 12p.
Autor:
Li, Zhixin, Lui, Kathy Nga-Chu, Lau, Sin-Ting, Lai, Frank Pui-Ling, Li, Peng, Chung, Patrick Ho-Yu, Wong, Kenneth Kak-Yuen, Tam, Paul Kwong-Hing, Garica-Barcelo, Maria-Mercedes, Hui, Chi-Chung, Sham, Pak Chung, Ngan, Elly Sau-Wai
Publikováno v:
Nature Communications; 4/15/2023, Vol. 14 Issue 1, p1-19, 19p