Výsledky vyhledávání - "Kathy N. Tomkinson"

Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites

Autor: Tara K. Crawford, Edward R. Lavallie, Tracy Hebert, Elisabeth A. Morris, Christopher John Corcoran, Mackie Stewart Andrews, Thomas McDonagh, Weilan Zeng, Priya S. Chockalingam, Kathy N. Tomkinson, Lisa A. Collins-Racie, Carl R. Flannery

Publikováno v: The Journal of biological chemistry. 277(45)

ADAMTS-4, also referred to as aggrecanase-1, is a glutamyl endopeptidase capable of generating catabolic fragments of aggrecan analogous to those released from articular cartilage during degenerative joint diseases such as osteoarthritis. Efficient a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5246ac6c68ec2ed792b05394c9999f51
https://pubmed.ncbi.nlm.nih.gov/12202483

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ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain

Autor: Kathy N. Tomkinson, Thomas McDonagh, Edward R. Lavallie, Amanda J. Fosang, John D. Sandy, Jennifer Westling, Vivian P. Thompson, Lisa A. Collins-Racie, Elisabeth A. Morris, Tracy Hebert

Publikováno v: The Journal of biological chemistry. 277(18)

Two major proteolytic cleavages, one at NITEGE(373)/A(374)RGSVI and the other at VDIPEN(341)/F(342)FGVGG, have been shown to occur in vivo within the interglobular domain of aggrecan. The Glu(373)-Ala(374) site is cleaved in vitro by aggrecanase-1 (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac954d0c9840fcf7f8c9299a9b720c2f
https://pubmed.ncbi.nlm.nih.gov/11854269

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