Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kathy Manchulenko"'
Autor:
Simon T. Barry, Vahe Bedian, David C. Blakey, Hazel M. Weir, Neil R. Smith, Dawn Baker, Li Peng, Melissa Damschroder, Song Cho, Philip Petteruti, Jane Kendrew, Cath Eberlein, Kathy Manchulenko, Brandon C. Clavette, Ian N. Foltz, Margaret Veldman-Jones, Sarah Ross, David W. Jenkins
PDF file - 153K, Figure to support screening for antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f789567bdbe38aa8242ddaae517a98
https://doi.org/10.1158/1535-7163.22497729.v1
https://doi.org/10.1158/1535-7163.22497729.v1
Autor:
Simon T. Barry, Vahe Bedian, David C. Blakey, Hazel M. Weir, Neil R. Smith, Dawn Baker, Li Peng, Melissa Damschroder, Song Cho, Philip Petteruti, Jane Kendrew, Cath Eberlein, Kathy Manchulenko, Brandon C. Clavette, Ian N. Foltz, Margaret Veldman-Jones, Sarah Ross, David W. Jenkins
PDF file - 98K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f07ae0e482808c3b8eacc87796d9ded
https://doi.org/10.1158/1535-7163.22497726.v1
https://doi.org/10.1158/1535-7163.22497726.v1
Autor:
Simon T. Barry, Vahe Bedian, David C. Blakey, Hazel M. Weir, Neil R. Smith, Dawn Baker, Li Peng, Melissa Damschroder, Song Cho, Philip Petteruti, Jane Kendrew, Cath Eberlein, Kathy Manchulenko, Brandon C. Clavette, Ian N. Foltz, Margaret Veldman-Jones, Sarah Ross, David W. Jenkins
The Notch signaling pathway has been implicated in cell fate determination and differentiation in many tissues. Accumulating evidence points toward a pivotal role in blood vessel formation, and the importance of the Delta-like ligand (Dll) 4-Notch1 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d542fb2b425861aad9c75220d50b1b
https://doi.org/10.1158/1535-7163.c.6535701.v1
https://doi.org/10.1158/1535-7163.c.6535701.v1
Autor:
Howard Monique L, Esther C. Leng, Nancy Sun, Vladimir I. Razinkov, Haruki Hasegawa, Clark Rutilio H, Janelle Stoops, William C. Fanslow, Zhi Liu, Min Shen, Kannan Gunasekaran, Zhonghua Hu, Martin Pentony, Kathy Manchulenko, Wei Yan, Ian Foltz, Hua Liu
Publikováno v:
Journal of Biological Chemistry. 290:7535-7562
Producing pure and well behaved bispecific antibodies (bsAbs) on a large scale for preclinical and clinical testing is a challenging task. Here, we describe a new strategy for making monovalent bispecific heterodimeric IgG antibodies in mammalian cel
Autor:
Kathy Manchulenko, Michael Brown, Cyr Clovis Chua De Imus, Ramil F. Latypov, Clark Rutilio H, Jane Carter, Zien Wilson, Randal R. Ketchem
Publikováno v:
mAbs
Therapeutic antibodies must encompass drug product suitable attributes to be commercially marketed. An undesirable antibody characteristic is the propensity to aggregate. Although there are computational algorithms that predict the propensity of a pr
Autor:
Brian Mingtung Chan, Robert Y.-T. Chou, Ognjen Grujic, Stephanie A Grauer, Kevin Graham, Christy Ann Thomson, Yang Li, Jennifer Weiszmann, Laura Sekirov, Jennitte Stevens, Ian Foltz, Kathy Manchulenko, Anita Badh, Thomas M. Dillon
Publikováno v:
Biochemical and biophysical research communications. 486(4)
Agonism of cell surface receptors by monoclonal antibodies is dependent not only on its ability to bind the target, but also to deliver a biological signal through receptors to the cell. Immunoglobulin G2 antibodies (IgG2s) are made up of a mixture o
Autor:
Peter J. Prince, Wei-Jian Pan, Larry C. Wienkers, XZ Xia, CM Sheckler, Hailing Hsu, C D Krill, Dominique C. Borie, AA Anderson, Ian Foltz, Palaniswami Rathanaswami, SP Lear, William A. Rees, Sonal K. Patel, F Lee, Kathy Manchulenko, BJ Harder, Doherty, JL Brandvig, JL Lynch, Brian Mingtung Chan, M Zhang, John A. Wisler, Kaz O Reynhardt
Publikováno v:
British Journal of Pharmacology. 169:51-68
Background and Purpose AMG 181 is a human anti-α4β7 antibody currently in phase 1 and 2 trials in subjects with inflammatory bowel diseases. AMG 181 specifically targets the α4β7 integrin heterodimer, blocking its interaction with mucosal address
Autor:
Michael Wittekind, Kannan Gunasekaran, Soo Bin Ng, Carla Forte, Min Shen, Marc W. Retter, Logan Garrett, Teresa L. Born, Kathy Manchulenko, Wei Yan, Anne Woodward, Heather Sweet, Ian Foltz, Martin Pentony
Publikováno v:
Journal of Biological Chemistry. 285:19637-19646
Naturally occurring IgG antibodies are bivalent and monospecific. Bispecific antibodies having binding specificities for two different antigens can be produced using recombinant technologies and are projected to have broad clinical applications. Howe
Publikováno v:
Analytical biochemistry. 414(1)
Affinity measurements of antigen-antibody interactions are generally performed using known concentrations of purified or recombinant materials. In addition, many technologies that measure affinity require the interacting components to be present in a
Autor:
Wayne R. Godfrey, Bruce Keyt, Minchao Chen, Caroline Darne Scatena, Lisa Perkins, Jaspal Singh Kang, Peter Koon Bong Ling, Kathy Manchulenko, Chadwick T. King, Ying Liu, Jennifer H. Richardson, Sukhbir Kang, Stan K. Morkowski, Ian Foltz, Hao Li
Publikováno v:
Blood. 106:4816-4816
Membrane-type serine protease 1 (MT-SP1)/Matriptase is a type II transmembrane serine protease that is primarily expressed in epithelial cells and is over-expressed in several cancers. MT-SP1 has been implicated in the processes of tumor cell invasio