Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kathy M. Schirripa"'
Autor:
Anthony J. Roecker, Kathy M. Schirripa, H. Marie Loughran, Ling Tong, Tao Liang, Kerry L. Fillgrove, Yuhsin Kuo, Kelly Bleasby, Hannah Collier, Michael D. Altman, Melissa C. Ford, Robert E. Drolet, Mali Cosden, Sarah Jinn, Nathan G. Hatcher, Lihang Yao, Monika Kandebo, Joshua D. Vardigan, Rosemarie B. Flick, Xiaomei Liu, Christina Minnick, Laura A. Price, Marla L. Watt, Wei Lemaire, Christine Burlein, Gregory C. Adam, Lauren A. Austin, Jacob N. Marcus, Sean M. Smith, Mark E. Fraley
Publikováno v:
ACS Medicinal Chemistry Letters. 14:146-155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a75f2713f77a436a3c71e753c7d659
https://doi.org/10.1021/acsmedchemlett.2c00441
https://doi.org/10.1021/acsmedchemlett.2c00441
Autor:
Scott D. Mosser, Joseph P. Vacca, Eric L. Moore, Rodney A. Bednar, Shane Roller, John F. Fay, Kathy M. Schirripa, Harold G. Selnick, Michael R. Wood, June J. Kim, Joseph G. Bruno, Christopher A. Salvatore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6827-6830
A previously utilized quinoline-for- N -phenylamide replacement strategy was employed against a central amide in a novel class of CGRP receptor antagonists. A unique and unexpected substitution pattern was ultimately required to maintain reasonable a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec70e90291b9b8a02fdc7f9b0e97ab5
https://doi.org/10.1016/j.bmcl.2010.08.105
https://doi.org/10.1016/j.bmcl.2010.08.105
Autor:
Joseph P. Vacca, Eric L. Moore, Joseph G. Bruno, Craig A. Stump, Christopher A. Salvatore, Harold G. Selnick, Stefanie A. Kane, Amy G. Quigley, Rodney A. Bednar, Ian M. Bell, Kathy M. Schirripa, John F. Fay, Scott D. Mosser, Shane Roller, Michael R. Wood, June J. Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5787-5790
A novel class of CGRP receptor antagonists was rationally designed by modifying a highly potent, but structurally complex, CGRP receptor antagonist. Initial modifications focused on simplified structures, with increased flexibility. Subsequent to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8f1786a9f3caf835e3719393c88bbc
https://doi.org/10.1016/j.bmcl.2009.07.134
https://doi.org/10.1016/j.bmcl.2009.07.134
Autor:
Jacquelynn J. Cook, Rodney A. Bednar, Thomayant Prueksaritanont, Yvonne M. Leonard, Michael R. Wood, Qin Mei, Richard W. Ransom, Ronald K. Chang, Emily D. Adarayn, Robert M. DiPardo, Jian Yu, Audrey A. Wallace, Wei Lemaire, Scott D. Kuduk, Kathy L. Murphy, G. R. Sitko, Scott D. Mosser, Christina N. Di Marco, Mark G. Bock, Frank C. Clayton, Bang-Lin Wan, Kathy M. Schirripa, Marie A. Holahan, Roger M. Freidinger, Dennis L. Bohn, Douglas J. Pettibone, Raymond S.L. Chang, Cuyue Tang, June J. Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:716-720
Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists incorporating α-hydroxy amides were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f489daa5ddd1907e6d600a79ad35db5d
https://doi.org/10.1016/j.bmcl.2007.11.050
https://doi.org/10.1016/j.bmcl.2007.11.050
Autor:
J. Fred Hess, Kathy M. Schirripa, Robert M. DiPardo, Christina N. Di Marco, Kathy L. Murphy, C. Meacham Harrell, Nova Sain, Jenny Wai, Marie A. Holahan, Douglas J. Pettibone, Ronald K. Chang, Mark G. Bock, Richard W. Ransom, June J. Kim, Jacquelynn J. Cook, Duane R. Reiss, Mark O. Urban, Cuyue Tang, Scott D. Kuduk, Thomayant Prueksaritanont, Michael R. Wood
Publikováno v:
Journal of Medicinal Chemistry. 50:272-282
A series of biphenylaminocyclopropane carboxamide based bradykinin B1 receptor antagonists has been developed that possesses good pharmacokinetic properties and is CNS penetrant. Discovery that the replacement of the trifluoropropionamide in the lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea572c63be0412753d1118489dc4b38
https://doi.org/10.1021/jm061094b
https://doi.org/10.1021/jm061094b
Autor:
Kathy M. Schirripa, Douglas J. Pettibone, Richard W. Ransom, Thomayant Prueksaritanont, Maricel Torrent, Mark G. Bock, Ronald K. Chang, Sookhee Ha, Michael R. Wood, June J. Kim, Christina N. Di Marco, Kathy L. Murphy, Cuyue Tang, Scott D. Kuduk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2791-2795
A series of 2,3-diaminopyridine bradykinin B1 antagonists was modified to mitigate the potential for bioactivation. Removal of the 3-amino group and incorporation of basic 5-piperazinyl carboxamides at the pyridine 5-position provided compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56018c1558d1e0be55b33488acb6d51
https://doi.org/10.1016/j.bmcl.2006.01.112
https://doi.org/10.1016/j.bmcl.2006.01.112
Autor:
Scott D. Kuduk, Christina N. Di Marco, Ronald K. Chang, Michael R. Wood, Kathy M. Schirripa, June J. Kim, Jenny M. C. Wai, Robert M. DiPardo, Kathy L. Murphy, Richard W. Ransom, C. Meacham Harrell, Duane R. Reiss, Marie A. Holahan, Jacquelynn Cook, J. Fred Hess, Nova Sain, Mark O. Urban, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p272-282, 11p