Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kathy M. McGown"'
Nonclinical Safety Assessment Nonclinical Safety Assessment A Guide to International Pharmaceutical Regulations Bringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty yea
Autor:
David P. Kelly, Rudolph Valentine, Susan M. Munley, Kathy M. McGown, Karin S. Bentley, William J. Brock
Publikováno v:
International Journal of Toxicology. 19:69-83
The acute, subchronic, and developmental and genetic toxicity of hydrofluorocarbon (HFC)-236fa and HFC-236ea were evaluated to assist in establishing proper handling guidance. In acute inhalation studies, rats were exposed whole body for 4 hours to v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c6a6de4f5452ee30a2c64f0d2dc01eb
https://doi.org/10.1080/109158100224881
https://doi.org/10.1080/109158100224881
Publikováno v:
Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations
Description: Bringing a new drug to market is a costly time–consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6a90b27af9e2bca4582a661907cd3b
https://doi.org/10.1002/9781118517000
https://doi.org/10.1002/9781118517000
Developmental toxicity and genotoxicity studies of 1,1,1,3,3,3-hexachloropropane (HCC-230fa) in rats
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 75(2)
The potential developmental toxicity and the in vitro and in vivo genotoxicity of HCC-230fa were assessed. In the developmental toxicity study, groups of 25 mated Crl:CD(R)(SD)BR rats were exposed (whole body) by inhalation to HCC-230fa over days 7-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945b85583adbe33c7134d9b4e8571725
https://pubmed.ncbi.nlm.nih.gov/12883086
https://pubmed.ncbi.nlm.nih.gov/12883086