Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kathy L. O'Connell"'
Autor:
D. Prabha Dias, Steven M. Murphy, David A. Agard, John T. Stults, Urvashi K. Patel, Kathy L. O'Connell, Michelle Moritz, Andrea M. Preble, Tim Stearns
Publikováno v:
Molecular Biology of the Cell. 12:3340-3352
The gamma-tubulin complex is a large multiprotein complex that is required for microtubule nucleation at the centrosome. Here we report the purification and characterization of the human gamma-tubulin complex and the identification of its subunits. T
The Disulfide Linkages and Glycosylation Sites of the Human Natriuretic Peptide Receptor-C Homodimer
Autor:
Alfred Engel, David L. Garbers, David G. Lowe, Kathy L. O'Connell, Stephen Wong, Chris Garcia, John T. Stults
Publikováno v:
Biochemistry. 33:11372-11381
The natriuretic peptide receptor-C (NPR-C) constitutes greater than 95% of the natriuretic peptide binding sites in vivo. This cell surface glycoprotein is a disulfide-linked homodimer with a subunit molecular weight of 68,000. Two sources and types
Publikováno v:
Analytical biochemistry. 258(1)
Hypertrophy of cardiac myocytes is a primary response of the heart to overload, and is an independent predictor of heart failure and death. Distinct cellular phenotypes are associated with hypertrophy resulting from different causes. These phenotypes
Autor:
Kathy L. O'Connell, John T. Stults
Publikováno v:
Electrophoresis. 18(3-4)
A number of proteins from a silver-stained two-dimensional (2-D) electrophoresis gel of mouse liver whole-cell lysate were identified by peptide mass mapping and sequence database searching. The excised protein spots were processed by in situ reducti
Autor:
Zhong Yin Zhang, Kathy L. O'Connell, Alfredo G. Tomasselli, John O. Hui, Roger A. Poorman, Ilene M. Reardon, Robert L. Heinrikson
Publikováno v:
Biochemistry. 30(36)
We report here for the first time that Zn2+ is an effective inhibitor of renin and the protease from HIV-1, two aspartyl proteinases of considerable physiological importance. Inhibition of renin is noncompetitive and is accompanied by binding of 1 mo