Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kathy L. Frost"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Progressive dysfunction and loss of neurons ultimately culminates in the symptoms and eventual fatality of prion disease, yet the pathways and mechanisms that lead to neuronal degeneration remain elusive. Here, we used RNAseq to profile transcription
Externí odkaz:
https://doaj.org/article/b93e609511584e249384707caaf117e3
Autor:
Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham, Robert Vendramelli, Yanlong Pei, Nikesh Tailor, Emelissa Valcourt, Anders Leung, Shihua He, Bryan D. Griffin, Jonathan Audet, Marnie Willman, Kevin Tierney, Alixandra Albietz, Kathy L. Frost, Jacob G.E. Yates, Robert C. Mould, Lily Chan, Yeganeh Mehrani, Jason P. Knapp, Jessica A. Minott, Logan Banadyga, David Safronetz, Heidi Wood, Stephanie Booth, Pierre P. Major, Byram W. Bridle, Leonardo Susta, Darwyn Kobasa, Sarah K. Wootton
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103219- (2021)
Summary: The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newc
Externí odkaz:
https://doaj.org/article/a9d6cd355eb7470ba0489696155667f5
Autor:
Ebony N. Gary, Bryce M. Warner, Elizabeth M. Parzych, Bryan D. Griffin, Xizhou Zhu, Nikesh Tailor, Nicholas J. Tursi, Mable Chan, Mansi Purwar, Robert Vendramelli, Jihae Choi, Kathy L. Frost, Sophia Reeder, Kevin Liaw, Edgar Tello, Ali R. Ali, Kun Yun, Yanlong Pei, Sylvia P. Thomas, Amira D. Rghei, Matthew M. Guilleman, Kar Muthumani, Trevor Smith, Sarah K. Wootton, Ami Patel, David B. Weiner, Darwyn Kobasa
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102699- (2021)
Summary: More than 100 million people have been infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Common laboratory mice are not susceptible to wild-type SARS-CoV-2 infection, challenging the development and testing of effec
Externí odkaz:
https://doaj.org/article/c729d41c6d47484fbcc09aab37def4d6
Autor:
Anna Majer, Sarah J. Medina, Debra Sorensen, Matthew J. Martin, Kathy L. Frost, Clark Phillipson, Kathy Manguiat, Stephanie A. Booth
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Multiple cell types and complex connection networks are an intrinsic feature of brain tissue. In this study we used expression profiling of specific microscopic regions of heterogeneous tissue sections isolated by laser capture microdissecti
Externí odkaz:
https://doaj.org/article/a5215f0e0d6d49c7899b2cea69864fb5
Autor:
Lise Lamoureux, Babu Sajesh, Jessy A. Slota, Sarah J. Medina, Matthew Mayor, Kathy L. Frost, Bryce Warner, Kathy Manguiat, Heidi Wood, Darwyn Kobasa, Stephanie A. Booth
Publikováno v:
Viruses, Vol 14, Iss 6, p 1218 (2022)
The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice c
Externí odkaz:
https://doaj.org/article/c6ad9fd4d82c42a2bae92b7388f370d4
Autor:
Laura P. van Lieshout, Jakob M. Domm, Tara N. Rindler, Kathy L. Frost, Debra L. Sorensen, Sarah J. Medina, Stephanie A. Booth, James P. Bridges, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 323-329 (2018)
Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly used gene delivery vectors are those based on adeno-associated virus (AAV). Despite these
Externí odkaz:
https://doaj.org/article/2911c1cd90a04b1b9fa657f70797c3f5
Autor:
Bryan D. Griffin, Kar Muthumani, Bryce M. Warner, Anna Majer, Mable Hagan, Jonathan Audet, Derek R. Stein, Charlene Ranadheera, Trina Racine, Marc-Antoine De La Vega, Jocelyne Piret, Stephanie Kucas, Kaylie N. Tran, Kathy L. Frost, Christine De Graff, Geoff Soule, Leanne Scharikow, Jennifer Scott, Gordon McTavish, Valerie Smid, Young K. Park, Joel N. Maslow, Niranjan Y. Sardesai, J. Joseph Kim, Xiao-jian Yao, Alexander Bello, Robbin Lindsay, Guy Boivin, Stephanie A. Booth, Darwyn Kobasa, Carissa Embury-Hyatt, David Safronetz, David B. Weiner, Gary P. Kobinger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes
Externí odkaz:
https://doaj.org/article/0c82ce7b193e4897a52f784c15fa050c
Autor:
Debra L. Sorensen, Laura P. van Lieshout, James P. Bridges, Sarah K. Wootton, Ashley A. Stegelmeier, John J Lawder, Stephanie A. Booth, Tara N. Rindler, Kathy L. Frost
Publikováno v:
Gene Therapy. 30:236-244
Naturally occurring adeno-associated virus (AAV) serotypes that bind to ligands such as AVB sepharose or heparin can be purified by affinity chromatography, which is a more efficient and scalable method than gradient ultracentrifugation. Wild-type AA
Autor:
Jonathan Audet, Sarah K. Wootton, Byram W. Bridle, Lily Chan, Lisa A. Santry, Logan Banadyga, Emelissa J. Valcourt, Darwyn Kobasa, Leonardo Susta, Kathy L. Frost, Marnie Willman, Anders Leung, Jessica A. Minott, Robert C. Mould, Nikesh Tailor, Alixandra Albietz, Bryce M. Warner, Jason P. Knapp, Pierre Major, Yanlong Pei, Yeganeh Mehrani, Robert Vendramelli, Phuc H. Pham, Kevin Tierney, Alexander Leacy, Heidi Wood, Jacob G. E. Yates, Mable Chan, David Safronetz, Stephanie A. Booth, Shihua He, Bryan D. Griffin
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103219-(2021)
iScience, Vol 24, Iss 11, Pp 103219-(2021)
The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newcastle dis
Autor:
Kevin Tierney, David Safronetz, Geoff Soule, Bryce M. Warner, Kathy L. Frost, Stephanie A. Booth, Derek R. Stein
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-7 (2019)
NPJ Vaccines
NPJ Vaccines
The World Health Organization has identified Lassa virus (LASV) as one of the top five pathogens to cause a severe outbreak in the near future. This study assesses the ability of a leading vaccine candidate, recombinant Vesicular stomatitis virus exp