Výsledky vyhledávání - "Kathy L Poulin"

Akademický článek

Adenovirus-Mediated Expression of the p14 Fusion-Associated Small Transmembrane Protein Promotes Cancer Cell Fusion and Apoptosis In Vitro but Does Not Provide Therapeutic Efficacy in a Xenograft Mouse Model of Cancer.

Autor: Carmen M Wong, Kathy L Poulin, Grace Tong, Carin Christou, Michael A Kennedy, Theresa Falls, John C Bell, Robin J Parks

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151516 (2016)

Adenoviruses (Ads) are used in numerous preclinical and clinical studies for delivery of anti-cancer therapeutic genes. Unfortunately, Ad has a poor ability to distribute throughout a tumor mass after intratumoral injection, and infects cells primari

Externí odkaz: https://doaj.org/article/825e776ffce4444e9cbb53baa38f6026

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Human adenoviral DNA association with nucleosomes containing histone variant H3.3 during the early phase of infection is not dependent on viral transcription or replication

Autor: Andrea N. Giberson, Bratati Saha, Kalisa Campbell, Robin J. Parks, Carin Christou, Kathy L. Poulin

Publikováno v: Biochemistry and Cell Biology. 96:797-807

Adenovirus (Ad) DNA undergoes dynamic changes in protein association as the virus progresses through its replicative cycle. Within the virion, the Ad DNA associates primarily with the virus-encoded, protamine-like protein VII. During the early phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd01719de38a3540dfbff771edcfa75
https://doi.org/10.1139/bcb-2018-0117

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Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy

Autor: Panayiotis O. Vacratsis, Justin Roberto, Robin J. Parks, Kathy L. Poulin

Publikováno v: ProteomicsREFERENCES. 21(13-14)

Spinal muscular atrophy (SMA) is an autosomal recessive disorder that represents a significant cause of infant mortality. SMA is characterized by reduced levels of the Survival Motor Neuron protein leading to the loss of alpha motor neurons in the sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa101c7f8a364e64d5d6605cdd8dd0cd
https://pubmed.ncbi.nlm.nih.gov/33893753

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The genome position of a therapeutic transgene strongly influences the level of expression in an armed oncolytic human adenovirus vector

Autor: Joshua Del Papa, Ryan G. Clarkin, Kathy L. Poulin, Robin J. Parks

Publikováno v: Virology. 561

Efficacy of oncolytic, conditionally-replicating adenovirus (CRAd) vectors can be enhanced by “arming” the vector with therapeutic transgenes. We examined whether inclusion of an intact early region 3 (E3) and the reptilian reovirus fusogenic p14

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb085ceb0f6df87a2987ccd032ebb86
https://pubmed.ncbi.nlm.nih.gov/34171766

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Autor: Kathy L. Poulin, John C. Bell, Grace Tong, Carmen M. Wong, Theresa Falls, Robin J. Parks, Michael A. Kennedy, Carin Christou

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151516 (2016)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3e4d5ecab7e73c63b114511f288056
http://europepmc.org/articles/PMC4795661?pdf=render

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Use of Cre/loxP recombination to swap cell binding motifs on the adenoviral capsid protein IX

Autor: Olga Vorobyova, Rashmi Kothary, Kathy L. Poulin, Robin J. Parks, Grace Tong, Madeline Pool

Publikováno v: Virology. 420(2):146-155

We used Cre/loxP recombination to swap targeting ligands present on the adenoviral capsid protein IX (pIX). A loxP-flanked sequence encoding poly-lysine (pK—binds heparan sulfate proteoglycans) was engineered onto the 3′-terminus of pIX, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248488bdbe86160146537d928bb8910a

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Assembly of Helper-Dependent Adenovirus DNA into Chromatin Promotes Efficient Gene Expression

Autor: Robin J. Parks, Milagros Risco Quiroz, Michael A. Kennedy, Kathy L. Poulin, P. Joel Ross, Carin Christou

Publikováno v: Journal of Virology. 85:3950-3958

Helper-dependent adenovirus (hdAd) vectors have shown tremendous potential in animal models of human disease in numerous preclinical studies. Expression of a therapeutic transgene can be maintained for several years after a single administration of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9bfe30c212fa4b97aa4be0f74cb72e7
https://doi.org/10.1128/jvi.01787-10

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Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX

Autor: Carin Christou, Rashmi Kothary, Robin J. Parks, Milagros Risco Quiroz, Adam C. Smith, Robert M. Lanthier, Karen L. Powell, Ian A. J. Lorimer, Ryan W. O'Meara, Kathy L. Poulin

Publikováno v: Journal of virology. 84(19)

Adenovirus (Ad) vectors are the most commonly used system for gene therapy applications, due in part to their ability to infect a wide array of cell types and tissues. However, many therapies would benefit from the ability to target the Ad vector onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a6854337963e1eca2571ab0272e6c5
https://pubmed.ncbi.nlm.nih.gov/20631131

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DNA genome size affects the stability of the adenovirus virion

Autor: Robin J. Parks, Adam C. Smith, Kathy L. Poulin

Publikováno v: Journal of virology. 83(4)

Replication-defective adenovirus (Ad) vectors can vary considerably in genome length, but whether this affects virion stability has not been investigated. Helper-dependent Ad vectors with a genome size of ∼30 kb were 100-fold more sensitive to heat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d1a466d199191ee2ef6e2e548e292b
https://pubmed.ncbi.nlm.nih.gov/19036812

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