Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathy K. Sarris"'
Autor:
Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach
Publikováno v:
Journal of Medicinal Chemistry. 61:11074-11100
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba127f0c7da3013553a7215d8180f4bd
https://doi.org/10.1021/acs.jmedchem.8b01098
https://doi.org/10.1021/acs.jmedchem.8b01098
Autor:
Dan Shi, Moore Nigel St John, Donald B. Konopacki, Kelly J. Larson, Gary Gintant, Kathy K. Sarris, Peter F. Bousquet, Sean C. Turner, Peng Zhang, Ayome Abibi, Christopher M. Harris, Tegest Kebede, Xiubo Tang, Adrian D. Hobson, John W. Maull, Elizabeth Louise van der Kam, Ana L. Aguirre, Youngjae Kim, Anurupa Shrestha
Publikováno v:
Journal of Medicinal Chemistry. 58:9154-9170
S1P5 is one of 5 receptors for sphingosine-1-phosphate and is highly expressed on endothelial cells within the blood-brain barrier, where it maintains barrier integrity in in vitro models (J. Neuroinflamm. 2012, 9, 133). Little more is known about th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e55edd033a09d0a8757996d1588c7cf
https://doi.org/10.1021/acs.jmedchem.5b00928
https://doi.org/10.1021/acs.jmedchem.5b00928
Autor:
Dietrich JD; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Longenecker KL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wilson NS; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Goess C; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Panchal SC; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Swann SL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Petros AM; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hobson AD; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Ihle D; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Song D; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Richardson P; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Comess KM; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Cox PB; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Dombrowski A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris K; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Donnelly-Roberts DL; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Duignan DB; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Gomtsyan A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Jung P; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Krueger AC; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mathieu S; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., McClure A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stoll VS; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wetter J; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Mankovich JA; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Hajduk PJ; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Vasudevan A; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Stoffel RH; AbbVie Bioresearch Center, 100 Research Drive, Worcester, Massachusetts 01605, United States., Sun C; Research & Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2021 Jan 14; Vol. 64 (1), pp. 417-429. Date of Electronic Publication: 2020 Dec 30.
Autor:
Tu NP; Discovery Chemistry & Technology, AbbVie, Inc., North Chicago, IL USA noah.tu@abbvie.com., Searle PA; Discovery Chemistry & Technology, AbbVie, Inc., North Chicago, IL USA., Sarris K; Discovery Chemistry & Technology, AbbVie, Inc., North Chicago, IL USA.
Publikováno v:
Journal of laboratory automation [J Lab Autom] 2016 Jun; Vol. 21 (3), pp. 459-69. Date of Electronic Publication: 2015 Jun 17.
Autor:
Swann SL; Global Pharmaceutical Research and Development, Abbott Laboratories, Dept Bldg AP10-L04L, Abbott Park, IL 60064-6217, United States. Steven.Swann@abbott.com, Merta PJ, Kifle L, Groebe D, Sarris K, Hajduk PJ, Sun C
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Oct 01; Vol. 20 (19), pp. 5787-92. Date of Electronic Publication: 2010 Apr 28.
Autor:
Nelson DW; Abbott Laboratories, Neuroscience Research and Advanced Technology, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064-6101, USA. derek.nelson@abbott.com, Sarris K, Kalvin DM, Namovic MT, Grayson G, Donnelly-Roberts DL, Harris R, Honore P, Jarvis MF, Faltynek CR, Carroll WA
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2008 May 22; Vol. 51 (10), pp. 3030-4. Date of Electronic Publication: 2008 Apr 26.
Autor:
Wendt MD; Cancer Research, Global Pharmaceutical R&D, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6101, USA. mike.d.wendt@abbott.com, Sun C, Kunzer A, Sauer D, Sarris K, Hoff E, Yu L, Nettesheim DG, Chen J, Jin S, Comess KM, Fan Y, Anderson SN, Isaac B, Olejniczak ET, Hajduk PJ, Rosenberg SH, Elmore SW
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jun 01; Vol. 17 (11), pp. 3122-9. Date of Electronic Publication: 2007 Mar 16.
Autor:
Mortell KH; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. kathleen.mortell@abbott.com, Anderson DJ, Lynch JJ 3rd, Nelson SL, Sarris K, McDonald H, Sabet R, Baker S, Honore P, Lee CH, Jarvis MF, Gopalakrishnan M
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Mar 01; Vol. 16 (5), pp. 1138-41. Date of Electronic Publication: 2005 Dec 27.
Autor:
Akritopoulou-Zanze I; Abbott, 100 Abbott Park Road, Abbott Park, IL 60044, USA. irini.zanze@abbott.com, Darczak D, Sarris K, Phelan KM, Huth JR, Song D, Johnson EF, Jia Y, Djuric SW
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jan 01; Vol. 16 (1), pp. 96-9. Date of Electronic Publication: 2005 Oct 10.