Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

Autor: Michael Bukrinsky, Vsevolod J. Makeev, Larisa Dubrovsky, Xueting Jin, Nikita G. Nikiforov, Howard S. Kruth, Andrey V. Zhelankin, A. E. Kel, Alexander N. Orekhov, Kathy K Foxx, Daria Stelmashenko, Igor A. Sobenin, Yumiko Oishi

Publikováno v: Current Pharmaceutical Design

Background: A hallmark of atherosclerosis is its complex pathogenesis, which is dependent on altered cholesterol metabolism and inflammation. Both arms of pathogenesis involve myeloid cells. Monocytes migrating into the arterial walls interact with m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3148ee927b857df8e3c0c6b92101ec7
https://doi.org/10.2174/1381612824666180911120039

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages

Autor: Igor A. Sobenin, Emile Zakiev, Yumiko Oishi, Tatiana Pushkarsky, Alexander N. Orekhov, Nikita G. Nikiforov, Larisa Dubrovsky, Xueting Jin, Anatol Kontush, Michael Bukrinsky, Kathy K Foxx, Howard S. Kruth, Andrey V. Zhelankin, Vasily N. Sukhorukov, Wilfried Le Goff, Vsevolod J. Makeev

High density lipoproteins (HDL) are key components of reverse cholesterol transport pathway. HDL removes excessive cholesterol from peripheral cells, including macrophages, providing protection from cholesterol accumulation and conversion into foam c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f23c959344625c977e1fdb27a4ce46
https://europepmc.org/articles/PMC6247801/

Transciptome analysis revealed inflammatory genes responsible for foam cell formation

Autor: Michael Bukrinsky, Igor A. Sobenin, Howard S. Kruth, Nikita G. Nikiforov, Kathy K Foxx, Daria Stelmashenko, Yumiko Oishi, Alexander E. Kel, Andrey V. Zhelankin, Alexander N. Orekhov, Vsevolod J. Makeev, Xueting Jin

Publikováno v: Atherosclerosis. 275:e116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84d8e07c281581e4aced667a0cf37191
https://doi.org/10.1016/j.atherosclerosis.2018.06.329

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages.

Autor: Orekhov AN; Institute of General Pathology and Pathophysiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia., Pushkarsky T; The George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Oishi Y; Department of Cellular and Molecular Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Nikiforov NG; Institute of General Pathology and Pathophysiology, Moscow, Russia; Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Moscow, Russia; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Zhelankin AV; Laboratory of postgenomic research, Federal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russia., Dubrovsky L; The George Washington University School of Medicine and Health Sciences, Washington, DC, USA., Makeev VJ; Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; Scientific Center 'Kurchatov Institute', Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, Russia; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow, Region, Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Foxx K; Kalen Biomedical LLC, Montgomery Village, MD, USA., Jin X; Experimental Atherosclerosis Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kruth HS; Experimental Atherosclerosis Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Sobenin IA; Institute of General Pathology and Pathophysiology, Moscow, Russia; Laboratory of Medical Genetics, Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Moscow, Russia., Sukhorukov VN; Institute of General Pathology and Pathophysiology, Moscow, Russia; Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, Hôpital de la Pitié, Paris, France., Zakiev ER; Institute of General Pathology and Pathophysiology, Moscow, Russia; Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, Hôpital de la Pitié, Paris, France., Kontush A; Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, Hôpital de la Pitié, Paris, France., Le Goff W; Sorbonne Université, Inserm, Institute of Cardiometabolism and Nutrition (ICAN), UMR_S1166, Hôpital de la Pitié, Paris, France., Bukrinsky M; The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: mbukrins@gwu.edu.

Publikováno v: Experimental and molecular pathology [Exp Mol Pathol] 2018 Oct; Vol. 105 (2), pp. 202-207. Date of Electronic Publication: 2018 Aug 16.