Výsledky vyhledávání - "Kathy J. Snow"

Data from Complex Oncogenic Translocations with Gene Amplification Are Initiated by Specific DNA Breaks in Lymphocytes

Autor: Kevin D. Mills, Oded Foreman, Rachel L. Elwell, Sarah A. Maas, Kathy J. Snow, Ellen C. Akeson, Bobbi-Jo Shirley, Travis L. Alley, Yong H. Woo, Sarah M. Wright

Chromosomal instability is a hallmark of many tumor types. Complex chromosomal rearrangements with associated gene amplification, known as complicons, characterize many hematologic and solid cancers. Whereas chromosomal aberrations, including complic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e74589113c517e27b7e81caf05e13c3a
https://doi.org/10.1158/0008-5472.c.6499217.v1

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Efficient in vivo neuronal genome editing in the mouse brain using nanocapsules containing CRISPR-Cas9 ribonucleoproteins

Autor: Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon E. Levine, Marina E. Emborg, Shaoqin Gong

Publikováno v: Biomaterials. 293:121959

Genome editing of somatic cells via clustered regularly interspaced short palindromic repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders, including neurological diseases. However, the dense and complex parenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50617b23e383b862d7ecaa0315451751
https://doi.org/10.1016/j.biomaterials.2022.121959

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Widespread genomic breaks from activation-induced cytidine deaminase are prevented by homologous recombination

Autor: Muneer G. Hasham, Kathy J. Snow, Jacquelyn Ames, Jane Maynard, Robert Y Wilpan, Benjamin L. King, Yishu He, Nina M Donghia, Eliot L. Coffey, Kevin D. Mills

Publikováno v: Nature immunology

Activation-induced cytidine deaminase (AID) is required for somatic hypermutation and immunoglobulin class switching in activated B cells. Because AID has no known target-site specificity, there have been efforts to identify non-immunoglobulin AID ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0c1c946c2da3feeccce538bcef5f3f
http://europepmc.org/articles/PMC2930818

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Complex Oncogenic Translocations with Gene Amplification Are Initiated by Specific DNA Breaks in Lymphocytes

Autor: Bobbi-Jo Shirley, Oded Foreman, Yong H. Woo, Rachel L. Elwell, Sarah A. Maas, Kevin D. Mills, Kathy J. Snow, Travis L. Alley, Sarah M. Wright, Ellen C. Akeson

Publikováno v: Cancer Research. 69:4454-4460

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8939a6be2042b284ceb0b52b78b7b23
https://doi.org/10.1158/0008-5472.can-08-4515

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Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase

Autor: Nina M Donghia, Jane Branca, Kathy J. Snow, Janet Stavnezer, Lindsay S. Shopland, Muneer G. Hasham, Mark D. Lessard, Kevin D. Mills

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 189(5)

Activation-induced cytidine deaminase (AID) initiates DNA double-strand breaks (DSBs) in the IgH gene (Igh) to stimulate isotype class switch recombination (CSR), and widespread breaks in non-Igh (off-target) loci throughout the genome. Because the D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdb3122c1ec41e960cd223a27b1820a
https://pubmed.ncbi.nlm.nih.gov/22826323

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Nuclear positioning, higher-order folding, and gene expression of Mmu15 sequences are refractory to chromosomal translocation

Autor: Sarah M. Wright, Laura C. Titus, Kevin D. Mills, Yong H. Woo, Lindsay S. Shopland, Kathy J. Snow

Publikováno v: Chromosoma. 120(1)

Nuclear localization influences the expression of certain genes. Chromosomal rearrangements can reposition genes in the nucleus and thus could impact the expression of genes far from chromosomal breakpoints. However, the extent to which chromosomal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4212757fa76331228253c5695c71c14c
https://pubmed.ncbi.nlm.nih.gov/20703494

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A mouse model of conditional lipodystrophy

Autor: Tali Shalom-Barak, Muneer G. Hasham, Angelique C. Paulk, Carol J. Bult, Li-Wen Huang, Vitaly Ablamunits, Yaacov Barak, Jason P. Affourtit, Joel E. Richardson, Timothy H. Young, Suyeon Kim, Kathy J. Snow

Lipodystrophies are syndromes of adipose tissue degeneration associated with severe defects in lipid and glucose homeostasis. We report here the generation and analysis of Pparg ldi , a targeted allele that confers conditional dominant lipodystrophy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ee3dde1a0b2616f34ec2c1ad22abb8
https://europepmc.org/articles/PMC2034232/

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Genetic linkage maps of the red flour beetle, Tribolium castaneum, based on bacterial artificial chromosomes and expressed sequence tags

Autor: Kathy J. Snow, Zaldy Doyungan, Richard W. Beeman, Marcé D. Lorenzen, Joël Savard, Teresa D. Shippy, Lindsey R Crumly, Jeffrey J. Stuart, Susan J. Brown

Publikováno v: Genetics. 170(2)

A genetic linkage map was constructed in a backcross family of the red flour beetle, Tribolium castaneum, based largely on sequences from bacterial artificial chromosome (BAC) ends and untranslated regions from random cDNA's. In most cases, dimorphis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d138bed13b81ad6103d4cbaf5eec50
https://pubmed.ncbi.nlm.nih.gov/15834150

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