Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kathy H. Pearson"'
Autor:
Sean P. Hollinshead, Emanuele Sher, Kathy H. Pearson, Ruud Zwart, Gordon I. McPhie, Lisa M. Broad, Martin Lee, Dell Colin Peter, S. Richard Baker, Renee Emkey, Louise Wallace
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:1108-1117
Here we report the discovery, by high-throughput screening, of three novel (2-amino-5-keto)thiazole compounds that act as selective potentiators of nicotinic acetylcholine receptors. Compound selectivity was assessed at seven human nicotinic acetylch
Autor:
Gordon I. McPhie, Ruud Zwart, Elizabeth A. Folly, Emanuele Sher, Laura R. Johnson, Ruth E. Beattie, Kathy H. Pearson, Stephen G. Volsen, Emma Bell, Non M. Evans, Giovanni Benedetti, Lisa M. Broad, Suchira Bose, Neil S. Millar, Peter J. Craig
Publikováno v:
European Journal of Pharmacology. 502:31-40
A chimera comprising the N-terminal region of the human alpha7 nicotinic acetylcholine receptor, fused to the transmembrane/C-terminal domains of the mouse serotonin 5-HT3 receptor, was constructed. Injection of the chimera cDNA into Xenopus oocytes,
Autor:
Stephen G. Volsen, Ruud Zwart, Lisa M. Broad, Suchira Bose, Jason P. Benton, Peter J. Craig, Gordon I. McPhie, Emanuele Sher, Giovanni Benedetti, Kathy H. Pearson, Non M. Evans
Publikováno v:
European Journal of Pharmacology. 466:31-39
Despite being cloned several years ago, the expression of functional nicotinic acetylcholine receptors containing the human alpha6 subunit in recombinant mammalian cell lines has yet to be demonstrated. The resulting lack of selective ligands has hin
Autor:
Emanuele Sher, John R. Boot, Peter J. Craig, Ruud Zwart, S. Richard Baker, Lisa M. Broad, Martine Keenan, Kathy H. Pearson, Richard J. Broadmore, Louise Wallace, Gordon I. McPhie, Catherine Felthouse
Publikováno v:
European Journal of Pharmacology. 452:137-144
5-Hydroxytryptamine 3 (5-HT(3)) and alpha 7 nicotinic receptors share high sequence homology and pharmacological cross-reactivity. An assessment of the potential role of alpha 7 receptors in many neurophysiological processes, and hence their therapeu
Autor:
Gordon I. McPhie, Emanuele Sher, Kathy H. Pearson, Tristan Baldwinson, Ruud Zwart, G. De Filippi, Lisa M. Broad
Publikováno v:
Neuropharmacology. 43:374-384
The effects of 5-hydroxyindole (5-HI) have been investigated on human alpha 7 nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes and GH4 cells, on native alpha 7 nAChRs expressed by IMR-32 cells and on alpha 7 nAChR-mediated even
Autor:
Giovanna De Filippi, Martine Keenan, J. Michael O’Neil, Martin Lee, S. Richard Baker, Emanuele Sher, Louise Wallace, Lisa M. Broad, Renee Emkey, Dell Colin Peter, Ruud Zwart, Sean P. Hollinshead, Kathy H. Pearson, Tristan Baldwinson, Gordon I. McPhie
Publikováno v:
Advances in Behavioral Biology ISBN: 9780387720746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::303a94d35840b4e443019e617ef21d14
https://doi.org/10.1007/978-0-387-72076-0_48
https://doi.org/10.1007/978-0-387-72076-0_48
Autor:
Peter J. Craig, Giovanni Benedetti, Michael Bodkin, Giovanna De Filippi, Kathy H. Pearson, Emanuele Sher, Gordon I. McPhie, Tristan Baldwinson, Ruud Zwart, Lisa M. Broad, Catherine Felthouse
Publikováno v:
Cholinergic Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d0e1214b49995c326bc3b196385a64
https://doi.org/10.3109/9780203493878-46
https://doi.org/10.3109/9780203493878-46
Autor:
Ruud Zwart, T.J.W. Sharples, Yao-Tseng Chen, Kathy H. Pearson, G. De Filippi, Tristan Baldwinson, Lisa M. Broad, Gordon I. McPhie, Emanuele Sher, Giovanni Benedetti
Publikováno v:
Current topics in medicinal chemistry. 4(3)
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the mammalian central nervous system (CNS). Despite this, very little was known, until recently, about their physiological role. In the periphery, nicotinic receptors mediate vital ex