Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Kathy Gately"'
Autor:
Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I. Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W. Kay, Susan Kennedy, Kenneth O’Byrne, Liam Grogan, Oscar Breathnach, Patrick G. Morris, Alexander J. Eustace, Joanna Fay, Robert Cummins, Anthony O’Grady, Roshni Kalachand, Norma O’Donovan, Fergal Kelleher, Aine O’Reilly, Mark Doherty, John Crown, Bryan T. Hennessy
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutation
Externí odkaz:
https://doaj.org/article/b0a3ce4f632e46aeb43bc18b4d3e61a7
Autor:
Susan Heavey, Paul Dowling, Gillian Moore, Martin P. Barr, Niamh Kelly, Stephen G. Maher, Sinead Cuffe, Stephen P. Finn, Kenneth J. O’Byrne, Kathy Gately
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract The PI3K-mTOR pathway is involved in regulating all hallmarks of cancer, and is often dysregulated in NSCLC, making it an attractive therapeutic target in this setting. Acquired resistance to PI3K-mTOR inhibition is a major hurdle to overcom
Externí odkaz:
https://doaj.org/article/a8ae152a78804d6da7975d71e4a44b98
Autor:
Martin P. Barr, Steven G. Gray, Kathy Gately, Emily Hams, Padraic G. Fallon, Anthony Mitchell Davies, Derek J. Richard, Graham P. Pidgeon, Kenneth J. O’Byrne
Publikováno v:
Molecular Cancer, Vol 19, Iss 1, Pp 1-2 (2020)
Since the publication of this work [1] and in response to a recent query that was brought to our attention in relation to the Western Blot in Figure 1(C) for NP2, protein lysates prepared around the same time as those presented in the manuscript in q
Externí odkaz:
https://doaj.org/article/056d4139098d453fb0b44b335d126544
Autor:
Toomey, Cathy E. Richards, Yasir Y. Elamin, Aoife Carr, Kathy Gately, Shereen Rafee, Mattia Cremona, Emer Hanrahan, Robert Smyth, Daniel Ryan, Ross K. Morgan, Susan Kennedy, Lance Hudson, Joanna Fay, Kenneth O’Byrne, Bryan T. Hennessy, Sinead
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10545
PTPN11 encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of KRAS and MEK. PTPN11/Shp2 somatic mutations occur frequently in Juvenile myelomonocytic leukaemia (JMML); however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::ee8c38ffc4f110df942cb7f7cbd611f9
Autor:
Jan Hendrik Rüschoff, Martina Haberecker, Zoi Tsourti, Kristiaan Nackaerts, Marc de Perrot, Luka Brcic, Ernest Nadal, Sotirios Tsimpoukis, Steven G. Gray, Luca Ampollini, Joachim G. Aerts, Emanuela Felley-Bosco, Michaela B. Kirschner, Kim Monkhorst, Birgit Weynand, Fatemeh Bavaghar-Zaeimi, Miroslav Samarzija, Roger Llatjos, Stephen P. Finn, Enrico Silini, Jan von der Thüsen, Nesa Marti, Karerina Vervita, Roswitha Kammler, Solange Peters, Rolf A. Stahel, Paul Baas, Isabelle Opitz, Rolf Stahel, Anita Hiltbrunner, Rosita Kammler, Patrick Vagenknecht, Barbara Ruepp, Urania Dafni, Panagiota Zygoura, Katerina Vervita, Georgia Dimopoulou, Charitini Andriakopoulou, Androniki Stavrou, Jan H. Rüschoff, Susanne Dettwiler, Fabiola Prutek, Christiane Mittmann, Bart Vrugt, Martina Friess, Alessandra Matter, Chloé Spichiger-Häusermann, Eric Verbeken, Birgit Weyenand, Liesbet Peeters, Marcello Tiseo, Enrico Maria Silini, Luigi Ventura, Letizia Gnetti, Paolo Carbognani, Fatemeh B. Zaeimi, Sven Seiwerth, Marko Jakopovic, Felipe Cardenal, Susana Lorente, Konstantinos Syrigos, Ioannis Vamvakaris, Paraskevi Boura, Steven Gray, Mutaz Mohammed Nur, Anne-Marie Baird, Martin Barr, Sinead Cuffe, Kathy Gately, Joachim Aerts
Publikováno v:
Modern Pathology, 35(12), 1888-1899. SPRINGERNATURE
Modern Pathology, 35(12), 1888-1899. Nature Publishing Group
Modern Pathology, 35(12), 1888-1899. Nature Publishing Group
Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Although histology and pathologic stage are important prognostic factors, better prognostic biomarkers are needed. The ribosomal protein S6 is a downstream target of the phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355b5c339b724ea833e0f7b1c96df40e
https://doi.org/10.1038/s41379-022-01145-0
https://doi.org/10.1038/s41379-022-01145-0
Publikováno v:
Cancers. 15:1635
Activating mutations in KRAS are highly prevalent in solid tumours and are frequently found in 35% of lung, 45% of colorectal, and up to 90% of pancreatic cancers. Mutated KRAS is a prognostic factor for disease-free survival (DFS) and overall surviv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acb1dc26ec1c548acf97be5ca30c446
https://doi.org/10.3390/cancers15061635
https://doi.org/10.3390/cancers15061635
Autor:
Thamir Mahgoub, Kenneth J. O'Byrne, John Crown, Clare Hughes, Frankie A. Holmes, Virginia Espina, Anthony Davies, Marion Le Gal, Alex J Eustace, Lance A. Liotta, Kathy Gately, Norma O'Donovan, Darran P. O'Connor, Max Hasmann, Denis M. Collins, Sinead Toomey, Dalal Alsultan, Jo Ballot, Birgit Bossenmaier, N. Gaynor, Stephen F. Madden, Bryan T. Hennessy, William M. Gallagher
Publikováno v:
Clin Cancer Res
Purpose: Antibody-dependent cell-mediated cytotoxicity (ADCC) is one mechanism of action of the monoclonal antibody (mAb) therapies trastuzumab and pertuzumab. Tyrosine kinase inhibitors (TKIs), like lapatinib, may have added therapeutic value in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74048f1c289e35d001933aa0a0fdd28
https://doi.org/10.1158/1078-0432.ccr-20-2007
https://doi.org/10.1158/1078-0432.ccr-20-2007
Autor:
Sabina Luszczak, Benjamin S. Simpson, Hayley C. Whitaker, Susan Heavey, Christopher Kumar, Vignesh Krishna Sathyadevan, Kathy Gately
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-10 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
PIM kinases have been shown to play a role in prostate cancer development and progression, as well as in some of the hallmarks of cancer, especially proliferation and apoptosis. Their upregulation in prostate cancer has been correlated with decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3149ee9fef8b537495a9a76275084e9
http://link.springer.com/article/10.1038/s41392-020-0109-y
http://link.springer.com/article/10.1038/s41392-020-0109-y
Autor:
Peter Godwin, Martin P. Barr, Erik W. Thompson, Sarah-Louise Ryan, Kathy Gately, Steven G. Gray, Stephen P. Finn, Derek J. Richard, Anne-Marie Baird, David Cormican, K. Umezawa, Kenneth J. O'Byrne, Susan Heavey, Sam Beard, A. Davies, Mark N. Adams
Publikováno v:
Lung Cancer. 135:217-227
Objectives The majority of patients with non-small cell lung cancer (NSCLC) present with advanced stage disease, at which time chemotherapy is usually the most common treatment option. While somewhat effective, patients treated with platinum-based re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e35d5c857f0f4b77f60a3466ca8b2c
https://doi.org/10.1016/j.lungcan.2019.07.006
https://doi.org/10.1016/j.lungcan.2019.07.006
Autor:
Gillian Moore, Stephen P. Finn, Katie E. O’Sullivan, Carmen Blanco-Aparicio, Lauren Brady, Samira Elbai, Siobhan Nicholson, Michael O'Neill, Clara Lightner, Kenneth J. O'Byrne, Kathy Gately, Susan Heavey, Sinead Cuffe, R. Ryan
Publikováno v:
Cancers
Volume 13
Issue 9
Cancers, Vol 13, Iss 2139, p 2139 (2021)
Volume 13
Issue 9
Cancers, Vol 13, Iss 2139, p 2139 (2021)
Simple Summary PIM kinases interact with major oncogenic players, including the PI3K/Akt pathway, and provide an escape mechanism leading to drug resistance. This study examined PIM kinase expression in NSCLC and the potential of PIM1 as a prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9006e0b0e7656dec7675ba99e16a9a38