Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kathy G. Jahangiri"'
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Xian Guo, Robert J. Ternansky, Brett R. Ullman, Lawrence C. Fritz, Robert Smidt, Ning Chen, Albert Schmitz, Lalitha Kodandapani, Donald S. Karanewsky, Jose-Luis Diaz, Steven D. Linton, Vincent J. Kalish, Brian Pham, U. von Krosigk, Kathy G. Jahangiri, Kevin J. Tomaselli, Steven P. Meduna, Joe C. Wu, Silvio Roggo, Edward D. Robinson
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(20)
A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2e6125c8589e60207c6bf4397139fc
https://pubmed.ncbi.nlm.nih.gov/12270186
https://pubmed.ncbi.nlm.nih.gov/12270186