Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy

Autor: Thomas G Beach, Lucia I Sue, Sarah Scott, Anthony J Intorcia, Jessica E Walker, Richard A Arce, Michael J Glass, Claryssa I Borja, Madison P Cline, Spencer J Hemmingsen, Sanaria Qiji, Analisa Stewart, Kayleigh N Martinez, Addison Krupp, Rylee McHattie, Monica Mariner, Ileana Lorenzini, Angela Kuramoto, Kathy E Long, Cécilia Tremblay, Richard J Caselli, Bryan K Woodruff, Steven Z Rapscak, Christine M Belden, Danielle Goldfarb, Parichita Choudhury, Erika D Driver-Dunckley, Shyamal H Mehta, Marwan N Sabbagh, Holly A Shill, Alireza Atri, Charles H Adler, Geidy E Serrano

Publikováno v: Journal of Neuropathology & Experimental Neurology. 82:457-466

Cerebral white matter rarefaction (CWMR) was considered by Binswanger and Alzheimer to be due to cerebral arteriolosclerosis. Renewed attention came with CT and MR brain imaging, and neuropathological studies finding a high rate of CWMR in Alzheimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc7a948f73150d9128a670c619f96e0e
https://doi.org/10.1093/jnen/nlad026

Faster cognitive decline in dementia due to Alzheimer disease with clinically undiagnosed Lewy body disease.

Autor: Michael Malek-Ahmadi, Thomas G Beach, Edward Zamrini, Charles H Adler, Marwan N Sabbagh, Holly A Shill, Sandra A Jacobson, Christine M Belden, Richard J Caselli, Brian K Woodruff, Steven Z Rapscak, Geoffrey L Ahern, Jiong Shi, John N Caviness, Erika Driver-Dunckley, Shyamal H Mehta, David R Shprecher, Bryan M Spann, Pierre Tariot, Kathryn J Davis, Kathy E Long, Lisa R Nicholson, Anthony Intorcia, Michael J Glass, Jessica E Walker, Michael Callan, Jasmine Curry, Brett Cutler, Javon Oliver, Richard Arce, Douglas G Walker, Lih-Fen Lue, Geidy E Serrano, Lucia I Sue, Kewei Chen, Eric M Reiman

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0217566 (2019)

BackgroundNeuropathology has demonstrated a high rate of comorbid pathology in dementia due to Alzheimer's disease (ADD). The most common major comorbidity is Lewy body disease (LBD), either as dementia with Lewy bodies (AD-DLB) or Alzheimer's diseas

Externí odkaz: https://doaj.org/article/20865cfb54d54fcb81882a55f80987e8

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

Autor: Joel Pullen, Jessica Filon, Sarah Scott, Douglas G. Walker, Richard J. Caselli, Geidy E. Serrano, Megan Saxon-LaBelle, John N. Caviness, Charles H. Adler, Thomas G. Beach, Alex C. Birdsill, Joseph G. Hentz, Marwan N. Sabbagh, Sandra Jacobson, Michael Malek-Ahmadi, Lisa D. Gale, Brittany Hoffman, Angelica Garcia, Brittany N. Dugger, Alexander Scroggins, Lih-Fen Lue, Geoffrey L. Ahern, Bryan K. Woodruff, Jiong Shi, Chera L. Maarouf, Anthony Intorcia, Lisa R. Nicholson, Anna D. Burke, Jessica Powell, Kathryn J. Davis, Alex E. Roher, Lucia I. Sue, Eric M. Reiman, Christine Belden, Kathy E. Long, Holly A. Shill, Erika Driver-Dunckley, Steven Z. Rapscak

Publikováno v: Neuropathology. 35:354-389

The Brain and Body Donation Program (BBDP) at Banner Sun Health Research Institute (http://www.brainandbodydonationprogram.org) started in 1987 with brain-only donations and currently has banked more than 1600 brains. More than 430 whole-body donatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad55f5c5c4b681be1ab2f698268ccd3
https://doi.org/10.1111/neup.12189

P2-430: RELATIONSHIPS BETWEEN LONGITUDINAL RATES OF LEARNING AND MEMORY DECLINE AND DIFFERENT FORMS OF CEREBROVASCULAR PATHOLOGY IN COGNITIVELY UNIMPAIRED BRAIN DONORS

Autor: Pierre N. Tariot, Kathryn J. Davis, Jessica E. Walker, Lisa R. Nicholson, Christine Belden, Michael Malek-Ahmadi, Jessica Powell, Jiong Shi, John N. Caviness, Marwan N. Sabbagh, Michael J. Glass, Steven Z. Rapscak, Geidy E. Serrano, Bryan K. Woodruff, Jasmine Curry, Kathy E. Long, Holly A. Shill, Geoffrey L. Ahern, David Shprecher, Lih-Fen Lue, Michael Callan, Erika Driver-Dunckley, Brett Cutler, Richard Arce, Richard J. Caselli, Charles H. Adler, Anthony Intorcia, Shyamal H. Mehta, Douglas G. Walker, Sandra Jacobson, Eric M. Reiman, Bryan Spann, Thomas G. Beach, Lucia I. Sue, Javon Oliver, Edward Zamrini

Publikováno v: Alzheimer's & Dementia. 15:P777-P777

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d304857a0381a43c230e130902a49558
https://doi.org/10.1016/j.jalz.2019.06.2837

Severe hyposmia distinguishes neuropathologically confirmed dementia with Lewy bodies from Alzheimer's disease dementia.

Autor: Beach, Thomas G.¹ (AUTHOR) Thomas.Beach@bannerhealth.com, Adler, Charles H.² (AUTHOR), Zhang, Nan³ (AUTHOR), Serrano, Geidy E.¹ (AUTHOR), Sue, Lucia I.¹ (AUTHOR), Driver-Dunckley, Erika² (AUTHOR), Mehta, Shayamal H.² (AUTHOR), Zamrini, Edouard E.¹ (AUTHOR), Sabbagh, Marwan N.⁴ (AUTHOR), Shill, Holly A.⁵ (AUTHOR), Belden, Christine M.¹ (AUTHOR), Shprecher, David R.¹ (AUTHOR), Caselli, Richard J.² (AUTHOR), Reiman, Eric M.⁶ (AUTHOR), Davis, Kathryn J.¹ (AUTHOR), Long, Kathy E.¹ (AUTHOR), Nicholson, Lisa R.¹ (AUTHOR), Intorcia, Anthony J.¹ (AUTHOR), Glass, Michael J.¹ (AUTHOR), Walker, Jessica E.¹ (AUTHOR)

Publikováno v: PLoS ONE. 4/22/2020, Vol. 15 Issue 4, p1-17. 17p.