Early Neural and Vascular Dysfunctions in Diabetic Rats Are Largely Sequelae of Increased Sorbitol Oxidation

Autor: Banavara L. Mylari, Peter J. Oates, Charles Kilo, Kathy Chang, Yasudo Ido, Jens R. Nyengaard, Ronald G. Tilton, Joseph R. Williamson

Publikováno v: Ido, Y, Nyengaard, J R, Chang, K, Tilton, R G, Kilo, C, Mylari, B L, Oates, P J & Williamson, J R 2010, ' Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation ', Antioxidants and Redox Signaling, vol. 12, no. 1, pp. 39-51 . https://doi.org/10.1089/ars.2009.2502

These experiments were undertaken to assess the importance of cytoplasmic (c) sorbitol oxidation versus mitochondrial (m) pyruvate oxidation in mediating neural and vascular dysfunction attributable to hyperglycemia in diabetic rats. Increased oxidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e59cdc21df6315e6634568f3c0a25cf
https://doi.org/10.1089/ars.2009.2502

TNF-α causes reversible in vivo systemic vascular barrier dysfunction via NO-dependent and -independent mechanisms

Autor: Thomas P. Misko, Wanda S. LeJeune, T. Bruce Ferguson, Joseph R. Williamson, Patrick M. Sullivan, Kathy Chang, Neil K. Worrall

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 273:H2565-H2574

Tumor necrosis factor (TNF-α) and nitric oxide (NO) are important vasoactive mediators of septic shock. This study used a well-characterized quantitative permeation method to examine the effect of TNF-α and NO on systemic vascular barrier function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b477b7a7ea3db61de0064b2b07df91
https://doi.org/10.1152/ajpheart.1997.273.6.h2565

Increased sciatic nerve blood flow in diabetic rats: assessment by 'molecular' vs. particulate microspheres

Autor: Joseph R. Williamson, Wanda S. LeJeune, Ronald G. Tilton, Kathy Chang, Yasuo Ido

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 273:E164-E173

Sciatic nerve blood flow in diabetic rats in typically increased or unchanged when assessed by the reference sample microsphere method in our laboratory. In contrast, blood flow is generally reported to be decreased approximately 50% when assessed wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4324750a7e88abecc8839644b14588f
https://doi.org/10.1152/ajpendo.1997.273.1.e164

TLR3 agonist improves survival to secondary pneumonia in a double injury model

Autor: Christopher G. Davis, Andrew H. Walton, Sarbani Ghosh, William Michael Dunne, Dale F. Osborne, Richard S. Hotchkiss, Jared T. Muenzer, Kathy Chang

Publikováno v: The Journal of surgical research. 182(2)

Background Toll-like receptors (TLR) can initiate various immune responses and are therefore activated under diverse infectious states. Previous studies have focused on TLR3 primarily as an antiviral pathway. However, recent research has demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1222e610a9b47437dcf807d0c72fa1b4
https://pubmed.ncbi.nlm.nih.gov/23083640

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

Autor: John A. Corbett, Khalid S Hasan, Jack R. Lancaster, Ronald G. Tilton, Joseph R. Williamson, Yasuo Ido, Jin Lin Wang, Kathy Chang, Michael L. McDaniel, Michael A. Sweetland

Publikováno v: Diabetes. 41:552-556

Increased blood flow and vascular leakage of proteins preferentially affect tissues that are sites of diabetic complications in humans and animals. These vascular changes in diabetic rats are largely prevented by aminoguanidine. Glucose-induced vascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333ac4ff22862d6bd310ede344a38b42
https://doi.org/10.2337/diab.41.4.552