Výsledky vyhledávání - "Kathy Alvarez"

Akademický článek

Group A Streptococcus Vaccine Targeting the Erythrogenic Toxins SpeA and SpeB Is Safe and Immunogenic in Rabbits and Does Not Induce Antibodies Associated with Autoimmunity

Autor: Matthew J. Troese, Elodie Burlet, Madeleine W. Cunningham, Kathy Alvarez, Rebecca Bentley, Nissy Thomas, Shanna Carwell, Garry L. Morefield

Publikováno v: Vaccines, Vol 11, Iss 9, p 1504 (2023)

Group A streptococcus (GAS) is a global pathogen associated with significant morbidity and mortality for which there is currently no licensed vaccine. Vaccine development has been slow, mostly due to safety concerns regarding streptococcal antigens a

Externí odkaz: https://doaj.org/article/c9863702893d40238175498b24db68da

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Akademický článek

IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes

Autor: Christine A. Kirvan, Heather Canini, Susan E. Swedo, Harry Hill, George Veasy, David Jankelow, Stanley Kosanke, Kent Ward, Yan D. Zhao, Kathy Alvarez, Andria Hedrick, Madeleine W. Cunningham

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2023)

Antecedent group A streptococcal pharyngitis is a well-established cause of acute rheumatic fever (ARF) where rheumatic valvular heart disease (RHD) and Sydenham chorea (SC) are major manifestations. In ARF, crossreactive antibodies and T cells respo

Externí odkaz: https://doaj.org/article/c970b122605d46d69a987890369c3ca9

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Akademický článek

Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections

Autor: Jennifer L. Chain, Kathy Alvarez, Adita Mascaro-Blanco, Sean Reim, Rebecca Bentley, Rebecca Hommer, Paul Grant, James F. Leckman, Ivana Kawikova, Kyle Williams, Julie A. Stoner, Susan E. Swedo, Madeleine W. Cunningham

Publikováno v: Frontiers in Psychiatry, Vol 11 (2020)

Movement, behavioral, and neuropsychiatric disorders in children have been linked to infections and a group of anti-neuronal autoantibodies, implying dopamine receptor-mediated encephalitis within the basal ganglia. The purpose of this study was to d

Externí odkaz: https://doaj.org/article/cc13e891712a473f9fa9d6919a16fd0e

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Akademický článek

Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection.

Autor: Harvey S Singer, Adda Mascaro-Blanco, Kathy Alvarez, Christina Morris-Berry, Ivana Kawikova, Hilla Ben-Pazi, Carol B Thompson, Syed F Ali, Edward L Kaplan, Madeleine W Cunningham

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120499 (2015)

Several autoantibodies (anti-dopamine 1 (D1R) and 2 (D2R) receptors, anti-tubulin, anti-lysoganglioside-GM1) and antibody-mediated activation of calcium calmodulin dependent protein kinase II (CaMKII) signaling activity are elevated in children with

Externí odkaz: https://doaj.org/article/020c3bedf8b44dec8760766e64d5c096

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P6288Autoantibodies in heart failure associate with disease severity and differentially expressed genes in apoptotic, fibrotic, and hypoxia pathways in cardiomyocytes

Autor: Patrick M. Gaffney, Stavros Stavrakis, K.A. White, J Myers, Graham B. Wiley, Kathy Alvarez, Courtney G. Montgomery, C Sandel, Madeleine W. Cunningham, Leslie T. Cooper, Lori Garman

Publikováno v: European Heart Journal. 40

Background Previous studies suggest that autoantibodies against cardiac myosin lead to dilated cardiomyopathy (DCM). Anti-cardiac myosin antibodies cross-react with the beta adrenergic receptor (βAR) and signal cAMP-dependent protein kinase A (PKA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a71a8ccbcbf73958879a9709dabd847
https://doi.org/10.1093/eurheartj/ehz746.0886

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Autoantibody Biomarkers for Basal Ganglia Encephalitis in Sydenham Chorea and Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infections

Autor: Kyle Williams, James F. Leckman, Paul Grant, Rebecca Bentley, Adita Mascaro-Blanco, Jennifer L Chain, Rebecca E. Hommer, Sean Reim, Madeleine W. Cunningham, Ivana Kawikova, Kathy Alvarez, Julie A. Stoner, Susan E. Swedo

Publikováno v: Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 11 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069db171e0e7c917e3e18664fdd4dbd3
https://pubmed.ncbi.nlm.nih.gov/32670106

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Antineuronal Antibodies in a Heterogeneous Group of Youth and Young Adults with Tics and Obsessive-Compulsive Disorder

Autor: Kathy Alvarez, Carol J. Cox, Kiki D. Chang, Julie A. Stoner, Madeleine W. Cunningham, Amir J Zuccolo, Adita Mascaro-Blanco, Erica Edwards

Publikováno v: Journal of Child and Adolescent Psychopharmacology. 25:76-85

Antineuronal antibodies have been implicated in tic and obsessive compulsive disorders (OCD) associated with group A streptococcal infections. We investigated antineuronal autoantibody levels as well as antibody-mediated neuronal cell signaling activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3611842c4099f37cfbb472438338a5
https://doi.org/10.1089/cap.2014.0048

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Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats

Autor: Dafna Lotan, Adita Mascaro-Blanco, Dan Frenkel, Lior Brimberg, Itai Benhar, Madeleine W. Cunningham, Daphna Joel, Kathy Alvarez

Publikováno v: Brain, Behavior, and Immunity. 38:249-262

Group A β-hemolytic streptococcal (GAS) infection is associated with a spectrum of neuropsychiatric disorders. The leading hypothesis regarding this association proposes that a GAS infection induces the production of auto-antibodies, which cross-rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7101ffd2a3877d408fda94939525bd
https://doi.org/10.1016/j.bbi.2014.02.009

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