Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kathy A. Joyce"'
Autor:
David Husband, M Moxham, Triantafillos Liloglou, Farida Alam, Brian Haylock, Carol Walker, Atik Baborie, Helen Wong, Julie R. Dunn, Andrew Brodbelt, R Sibson, Kathy A. Joyce, Daniel Crooks, Aditya Shenoy
Publikováno v:
British Journal of Cancer
Background: Epigenetic silencing of O6-methylguanine-DNA-methyltransferase (MGMT) by promoter methylation is associated with improved survival in glioblastomas treated with alkylating agents. In this study, we investigated MGMT promoter methylation i
Autor:
J Prosser, Brian Haylock, David L Fildes, K. Kopitzki, Carol Walker, Sobhan Vinjamuri, David Husband, Kathy A. Joyce, Michael D. Jenkinson, D. G. Du Plessis, John Broome, Peter C. Warnke, Trevor A Smith
Publikováno v:
British Journal of Cancer
The -1p/-19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated the predictive and prognostic significanc
Autor:
Brian Haylock, John Broome, Michael D. Jenkinson, David Husband, Daniel du Plessis, Kathy A. Joyce, Carol Walker, Peter C. Warnke, Trevor S. Smith, Diane Fildes
Publikováno v:
Neuroradiology
Introduction The biological factors responsible for differential chemoresponsiveness in oligodendroglial tumours with or without the −1p/−19q genotype are unknown, but tumour vascularity may contribute. We aimed to determine whether dynamic susce
Histological growth patterns and genotype in oligodendroglial tumours: correlation with MRI features
Autor:
Peter C. Warnke, Kathy A. Joyce, Michael D. Jenkinson, Carol Walker, Trevor S. Smith, Daniel du Plessis
Publikováno v:
Brain. 129:1884-1891
Oligodendroglial neoplasms with the -1p/-19q genotype are more indolent with longer survival and increased therapeutic responsiveness than those with intact 1p/19q, but the biological basis for these clinical differences is unclear. Recent research s
Autor:
Michael D. Jenkinson, Brian Haylock, Peter C. Warnke, Kathy A. Joyce, David Husband, Carol Walker, Trevor R.F. Smith, John Broome, D. G. Du Plessis, Diane Fildes
Publikováno v:
Neurology. 66:1661-1667
The -1p/-19q genotype has been associated with prolonged survival and chemosensitivity in oligodendroglial neoplasms, but the predictive and prognostic significance of genotype in the routine clinic is not established.The authors investigated allelic
Publikováno v:
Neuropathology and Applied Neurobiology. 26:441-447
Investigation of the clinical significance of genetic alterations in gliomas requires molecular genetic analysis using samples from retrospective or prospective clinical studies. However, diagnostic tissue is often severely limited and because of fix
Cellularity and apparent diffusion coefficient in oligodendroglial tumours characterized by genotype
Autor:
Kathy A. Joyce, Trevor S. Smith, Michael D. Jenkinson, Daniel du Plessis, Carol Walker, Andrew Brodbelt
Publikováno v:
Journal of neuro-oncology. 96(3)
Purpose Apparent diffusion coefficient (ADC) describes water diffusion within tissues. Previous studies report a negative linear correlation between minimum ADC and tumour cellularity in different types of gliomas, but there are no studies in oligode
Autor:
Trevor S. Smith, Michael D. Jenkinson, Andrew Brodbelt, Kathy A. Joyce, Carol Walker, Peter C. Warnke
Publikováno v:
Journal of magnetic resonance imaging : JMRI. 26(6)
Purpose To investigate whether oligodendroglial tumors with or without 1p/19q loss differ in their diffusion-weighted imaging characteristics. Oligodendroglial tumors with or without 1p/19q loss differ in their therapeutic responsiveness and prognosi
Autor:
Diane Fildes, Kathy A. Joyce, Carol Walker, Peter C. Warnke, Trevor S. Smith, D. G. Du Plessis, Michael D. Jenkinson
Publikováno v:
Neurology. 64(12)
Background: Oligodendroglial neoplasms with combined loss of chromosomes 1p and 19q may have a good prognosis and respond to procarbazine-lomustine (CCNU)-vincristine(PCV) chemotherapy.Objective: To determine whether single voxel magnetic resonance s
Autor:
Diane Fildes, Abigail Gee, Brian Haylock, David Husband, John Broome, Daniel du Plessis, Peter C. Warnke, Kathy A. Joyce, Trevor S. Smith, Carol Walker
Publikováno v:
Annals of neurology. 57(6)
To evaluate the role of molecular genetics in the routine clinic, we investigated allelic imbalance at 1p36, 19q13, 17p13, 10p12-15, and 10q22-26 and p53 mutation in 100 oligodendroglial neoplasms diagnosed at a single treatment center between 2000 a