Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Kathy A. Aldern"'
Autor:
Karl Y. Hostetler, James R. Beadle, Nadejda Valiaeva, Xing-Quan Zhang, Robert T. Schooley, Kathy A. Aldern
Publikováno v:
Antiviral Res
Pre-exposure prophylaxis (PrEP) with topically or systemically administered antiretroviral agents can prevent acquisition of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials using tenofovir-containing agents, HIV-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58d40531d1424fbd0b3992dc6014926
https://escholarship.org/uc/item/7xq316mk
https://escholarship.org/uc/item/7xq316mk
Autor:
Tracy L. Hartman, Robert W. Buckheit, Kathy A. Keith, Jei-Hwa Yu, Louise T. Chow, Nadejda Valiaeva, James R. Beadle, Emma A. Harden, Thomas R. Broker, Mark N. Prichard, Karl Y. Hostetler, Guang Yang, Kathy A. Aldern
Publikováno v:
Journal of Medicinal Chemistry. 59:10470-10478
Human papillomavirus (HPV) high-risk genotypes such as HPV-16 and HPV-18 cause the majority of anogenital tract carcinomas, including cervical cancer, the second most common malignancy in women worldwide. Currently there are no approved antiviral age
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:586-597
The acyclic nucleoside phosphonate drug ( S )-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [( S )-HPMPA], is a broad-spectrum antiviral and antiparasitic agent. Previous work has shown that the active intracellular metabolite of this compound, ( S
Autor:
Jacqueline C. Ruiz, Kathy A. Aldern, Earl R. Kern, Karl Y. Hostetler, Kathy A. Keith, James R. Beadle, Caroll B. Hartline
Publikováno v:
Antiviral Research. 75:87-90
Esterification of cidofovir (CDV), an antiviral nucleoside phosphonate, with alkyl or alkoxyalkyl groups increases antiviral activity by enhancing cell uptake and conversion to CDV diphosphate. Hexadecyloxypropyl-CDV (HDP-CDV) has been shown to be 40
Autor:
Lora Melman, Kathy A. Aldern, Gelita Owens, James R. Beadle, Jill Schriewer, Karl Y. Hostetler, Julissa Trahan, R. Mark L. Buller
Publikováno v:
Antiviral Research. 73:212-218
Hexadecyloxypropyl-cidofovir (HDP-CDV) has been shown to be orally active against lethal infection with orthopoxviruses including, mousepox, cowpox, vaccinia and rabbitpox. The alkoxyalkyl group provides oral absorption and reduces greatly the amount
Autor:
Saskia E Hostetler, John W. Mellors, Douglas D. Richman, Karl Y. Hostetler, Hammond Jennifer, Ting-Chao Chou, James R. Beadle, Ganesh D. Kini, Kathy A. Aldern
Publikováno v:
Antiviral Chemistry and Chemotherapy. 11:213-219
Monoalkyl ether lipid analogues of foscarnet (phosphonoformate, PFA) exhibit substantially greater in vitro antiviral activity than unmodified PFA against human immunodeficiency virus type 1 (HIV-1). Our previous studies indicate that the length of t
Autor:
Kathy A. Aldern, Douglas D. Richman, Ganesh D. Kini, James R. Beadle, Michael F. Gardner, Karl Y. Hostetler, Kristine N. Wright
Publikováno v:
Antiviral Chemistry and Chemotherapy. 9:33-40
In a previous study, we reported that 1- O-octadecyl- sn-glycero-3-foscarnet (ODG-PFA) was 40 to 93 times more potent than free foscarnet (PFA) in human cytomegalovirus (HCMV)-, herpes simplex virus type 1 (HSV-1)- and human immunodeficiency virus ty
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:2857-2859
( S )-9-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine [( S )-HPMPA], is an effective broad-spectrum antiviral against many DNA viruses but has been reported to be inactive against human immunodeficiency virus (HIV). We synthesized several alkoxyalkyl
Autor:
James R. Beadle, Kathy A. Aldern, Karl Y. Hostetler, Douglas D. Richman, Hong Xie, Ganesh D. Kini
Publikováno v:
Antiviral Research. 36:43-53
The identification of more effective and less toxic foscarnet (PFA) analogs for antiviral therapy would be useful. We recently synthesized 1-O-octadecyl-sn-glycero-3-phosphonoformic acid (ODG-PFA) and noted a 93-fold increase in its anti-HCMV activit
Autor:
Sam Kacew, Kathy A. Aldern, Michael F. Gardner, Karl Y. Hostetler, Debora Christine Ebert, Terry L. Beard, Christy M. McCloud, Mark J. Reasor
Publikováno v:
Toxicology. 106:139-147
Amiodarone (AD) and its major metabolite, desethylamiodarone (desethylAD), are both phospholipogenic. The present study was undertaken to evaluate the comparative susceptibilities of male Fischer-344 and Sprague-Dawley rats to AD-induced phospholipid