Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Kathryn Westendorf"'
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menachery, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110812- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of c
Externí odkaz:
https://doaj.org/article/daeff3ff2f814504a3643f35bb419fcf
Autor:
Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, III, Alexandra Schäfer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109929- (2021)
Summary: Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineeri
Externí odkaz:
https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0
Autor:
Yue Shen, Matthew R. Zeglinski, Christopher T. Turner, Sheetal A. Raithatha, Zhenguo Wu, Valerio Russo, Cameron Oram, Sho Hiroyasu, Layla Nabai, Hongyan Zhao, Tatjana Bozin, Kathryn Westendorf, Irina Kopko, Rachel Huang, Steve Arns, Jason Tan, Haishan Zeng, Anthony Boey, Richard Liggins, James Jaquith, Dale R. Cameron, Anthony Papp, David J. Granville
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Chronic wounds: Gel encourages healing and reduces scarring A promising, recently developed topical treatment prevents detrimental enzyme activity in burn wounds, accelerates healing and reduces scarring. Chronic wounds that do not heal fully and req
Externí odkaz:
https://doaj.org/article/14e3cf5a39f347f1ae1f7819d91fe470
Autor:
Kathryn Westendorf, Stefanie Žentelis, Lingshu Wang, Denisa Foster, Peter Vaillancourt, Matthew Wiggin, Erica Lovett, Robin van der Lee, Jörg Hendle, Anna Pustilnik, J. Michael Sauder, Lucas Kraft, Yuri Hwang, Robert W. Siegel, Jinbiao Chen, Beverly A. Heinz, Richard E. Higgs, Nicole L. Kallewaard, Kevin Jepson, Rodrigo Goya, Maia A. Smith, David W. Collins, Davide Pellacani, Ping Xiang, Valentine de Puyraimond, Marketa Ricicova, Lindsay Devorkin, Caitlin Pritchard, Aoise O’Neill, Kush Dalal, Pankaj Panwar, Harveer Dhupar, Fabian A. Garces, Courtney A. Cohen, John M. Dye, Kathleen E. Huie, Catherine V. Badger, Darwyn Kobasa, Jonathan Audet, Joshua J. Freitas, Saleema Hassanali, Ina Hughes, Luis Munoz, Holly C. Palma, Bharathi Ramamurthy, Robert W. Cross, Thomas W. Geisbert, Vineet Menacherry, Kumari Lokugamage, Viktoriya Borisevich, Iliana Lanz, Lisa Anderson, Payal Sipahimalani, Kizzmekia S. Corbett, Eun Sung Yang, Yi Zhang, Wei Shi, Tongqing Zhou, Misook Choe, John Misasi, Peter D. Kwong, Nancy J. Sullivan, Barney S. Graham, Tara L. Fernandez, Carl L. Hansen, Ester Falconer, John R. Mascola, Bryan E. Jones, Bryan C. Barnhart
Publikováno v:
bioRxiv
SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization when administered early during COVID-19 disease. However, the emergence of variants of concern has negatively impacted the therapeutic use of some authorized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb8cf2c168e04af64aeb77ae8c382f6
https://europepmc.org/articles/PMC8109210/
https://europepmc.org/articles/PMC8109210/
Autor:
Ethan J. Fritch, Ande West, Sarah R. Leist, Kenneth H. Dinnon, James D. Chappell, Ralph S. Baric, Mark R. Denison, Ching-Lin Hsieh, Krithika Muthuraman, Laura J. Stevens, Alexandra Schäfer, Anne P. Werner, Kizzmekia S. Corbett, Barney S. Graham, Kathryn Westendorf, Ester Falconer, Jason S. McLellan, Jory A. Goldsmith, Olubukola M. Abiona, Chia-Wei Chou
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109929-(2021)
Cell Reports
Cell Reports
Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineering to rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f092e0c8eca2a9b9fad41a52098cfc35
Autor:
Krithika Muthuraman, Richard E. Higgs, Carl L. Hansen, Maren de Vries, Mark J. Mulligan, Kizzmekia S. Corbett, Ping Xiang, Nicole V. Johnson, Jory A. Goldsmith, Jason S. McLellan, John R. Mascola, Marissa H. Piper, Lucas Kraft, Jamie L. Blackbourne, Samuel J. Hinshaw, Davide Pellacani, Stefanie Žentelis, Christopher M. Wiethoff, Solmaz Sobhanifar, David R. Martinez, Franz J. Triana, Thomas P. Cujec, Barney S. Graham, Robert W. Cross, Ching-Lin Hsieh, Beverly A. Heinz, Denisa Foster, Ralph S. Baric, Sean A. Tycho, Jorg Hendle, David Collins, Eun Sung Yang, Ester Falconer, Daniel Wrapp, Andrew C. Adams, Roza Bidshahri, A. Pustilnik, Yuri Hwang, Adil Mohamed, Julian Davies, Yi Zhang, Patricia Brown-Augsburger, Bryan Edward Jones, Shawn J. Berens, Kevin R. Jepson, Bryan C. Barnhart, Kathryn Westendorf, Lingshu Wang, Viktoriya Borisevich, Meike Dittmann, Maia A. Smith, Deepa Balasubramaniam, Thomas W. Geisbert, Rodrigo Goya, Hayley M. Belli, Olubukola M. Abiona, Marie I. Samanovic
Publikováno v:
bioRxiv
Science Translational Medicine
Science Translational Medicine
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics that may bridge widespread vaccination
Autor:
Mark J. Mulligan, Kizzmekia S. Corbett, Marissa H. Piper, Nicole V. Johnson, Jory A. Goldsmith, Roza Bidshahri, Carl L. Hansen, Robert W. Cross, Daniel Wrapp, A. Pustilnik, Yuri Hwang, Julian Davies, Adil Mohamed, Kathryn Westendorf, Beverly A. Heinz, Olubukola M. Abiona, Lucas Kraft, Jamie L. Blackbourne, Andrew C. Adams, Marie I. Samanovic, Samuel J. Hinshaw, Bryan Edward Jones, Sean A. Tycho, Christopher M. Wiethoff, Shawn J. Berens, Krithika Muthuraman, Stefanie Zentelis, Thomas W. Geisbert, Richard E. Higgs, Ralph S. Baric, Lingshu Wang, Jorg Hendle, Maia A. Smith, Hayley M. Belli, Meike Dittmann, Deepa Balasubramaniam, Solmaz Sobhanifar, Rodrigo Goya, Denisa Foster, John R. Mascola, Viktoriya Borisevich, Thomas P. Cujec, Barney S. Graham, Ping Xiang, Jason S. McLellan, Davide Pellacani, David R. Martinez, Maren de Vries, Patricia Brown-Augsburger, Franz J. Triana, David Collins, Ester Falconer, Kevin R. Jepson, Bryan C. Barnhart, Ching-Lin Hsieh
Publikováno v:
Science Translational Medicine
LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection.
A monoclonal for SARS-CoV-2 Among the most promising therapeutic options for individuals with coro
A monoclonal for SARS-CoV-2 Among the most promising therapeutic options for individuals with coro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910c20bb8473b8eebf9a1ddc2b988951
https://doi.org/10.1101/2020.09.30.318972
https://doi.org/10.1101/2020.09.30.318972
Autor:
Yue Shen, Tatjana Bozin, Lubos Bohunek, John E. Eriksson, Lisa S. Ang, Yulia Merkulova, Ivy Hsu, Fang Cheng, David J. Granville, Kathryn Westendorf, Bruce M. McManus, Sheetal A. Raithatha, Sarah J. Williams, Hongyan Zhao, Michael A. Seidman, Leigh G. Parkinson, Mehul Sharma, R. Chris Bleackley
Publikováno v:
American Journal of Pathology. 186(1):87-100
Cardiac fibrosis is observed across diverse etiologies of heart failure. Granzyme B (GzmB) is a serine protease involved in cell-mediated cytotoxicity in conjunction with the pore-forming protein, perforin. Recent evidence suggests that GzmB also con
Autor:
Tatjana Bozin, Christopher T. Turner, Sho Hiroyasu, James Brian Jaquith, Haishan Zeng, Matthew R. Zeglinski, Valerio Russo, Kathryn Westendorf, David J. Granville, Steve Arns, Richard Liggins, Cameron Oram, Yue Shen, Layla Nabai, Dale R. Cameron, Sheetal A. Raithatha, Irina Kopko, Rachel Huang, Jason Samuel Tan, Zhenguo Wu, Anthony Papp, Anthony Boey, Hongyan Zhao
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-11 (2018)
Granzyme B (GzmB) is a serine protease that has long been thought to function exclusively in lymphocyte-mediated apoptosis. In recent years, this paradigm has been revisited due to the recognition that GzmB accumulates in the extracellular milieu in
Autor:
Yulia Merkulova, Mehul Sharma, Hongyan Zhao, Leigh G. Parkinson, Kathryn Westendorf, Sheetal A. Raithatha, Robert Chris Bleackley, Yue Shen, David J. Granville
Publikováno v:
Biological chemistry. 397(9)
Chronic non-healing wounds including diabetic, venous, and decubitus skin ulcers are currently lacking effective therapies. Non-healing diabetic ulcers can lead to amputations as progress into a highly chronic state before detection and existing trea