Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kathryn W. Underwood"'
Autor:
Ravindra Kumar, Jasbir Seehra, Kathryn W. Underwood, R. Scott Pearsall, Jeffrey A. Ucran, Nicolas Solban, Travis E. Monnell, Roselyne Castonguay, Asya V. Grinberg, Aaron W. Mulivor, Eileen G. Pobre, Dianne Mitchell
Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of the transforming growth factor-β superfamily of receptors known to play an essential role in modulating angiogenesis and vessel maintenance. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d62b66268345b52b0f0b8aa7db8311c
https://doi.org/10.1158/1535-7163.c.6532256
https://doi.org/10.1158/1535-7163.c.6532256
Autor:
Ravindra Kumar, Jasbir Seehra, Kathryn W. Underwood, R. Scott Pearsall, Jeffrey A. Ucran, Nicolas Solban, Travis E. Monnell, Roselyne Castonguay, Asya V. Grinberg, Aaron W. Mulivor, Eileen G. Pobre, Dianne Mitchell
Supplementary Table 1 from ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5eebbcf9ce0bdb38c2a3af3223ee68
https://doi.org/10.1158/1535-7163.22486142
https://doi.org/10.1158/1535-7163.22486142
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex
Autor:
Jasbir Seehra, Katia Liharska, June Liu, Jeffrey A. Ucran, Patricia Lowden, Erik Martinez-Hackert, Kathryn W. Underwood, Sharon A. Townson, Chloe Greppi, Asya Grinberg, Ravindra Kumar, Sako Dianne S
Publikováno v:
Journal of Biological Chemistry. 287:27313-27325
Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β superfamily, is an important regulator of normal blood vessel development as well as pathological tumor angiogenesis. As such, ALK1 is an important ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1748287efd39885ad25e0e67b95c07e
https://doi.org/10.1074/jbc.m112.377960
https://doi.org/10.1074/jbc.m112.377960
Autor:
Ravindra Kumar, Asya Grinberg, R. Scott Pearsall, Kathryn W. Underwood, Robert G. Matthews, Nicolas Solban, Eric D. Werner, Aaron W. Mulivor, Roselyne Castonguay, Sako Dianne S, Jasbir Seehra, Eleonora Presman
Publikováno v:
Journal of Biological Chemistry. 286:30034-30046
Endoglin (CD105), a transmembrane protein of the transforming growth factor β superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1). The soluble f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d9a63d859a831ed8d8663b1a9eb20b
https://doi.org/10.1074/jbc.m111.260133
https://doi.org/10.1074/jbc.m111.260133
Autor:
Jennifer Lachey, Kathryn W. Underwood, Matthew S. Spaits, Samuel M. Cadena, Kathleen N. Tomkinson, Ravindra Kumar, Travis E. Monnell, R. Scott Pearsall
Publikováno v:
Journal of Applied Physiology. 109:635-642
This is the first report that inhibition of negative regulators of skeletal muscle by a soluble form of activin type IIB receptor (ACE-031) increases muscle mass independent of fiber-type expression. This finding is distinct from the effects of selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531e1fd51c10a4aa9c6349a66ddb2f22
https://doi.org/10.1152/japplphysiol.00866.2009
https://doi.org/10.1152/japplphysiol.00866.2009
Autor:
Ravindra Kumar, Roselyne Castonguay, Travis E. Monnell, Jasbir Seehra, Kathryn W. Underwood, Dianne C. Mitchell, Aaron W. Mulivor, Eileen Pobre, R. Scott Pearsall, Nicolas Solban, Jeffrey A. Ucran, Asya Grinberg
Publikováno v:
Molecular Cancer Therapeutics. 9:379-388
Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of the transforming growth factor-β superfamily of receptors known to play an essential role in modulating angiogenesis and vessel maintenance. In the present st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6d29c967b30e7e630139bda1ff6884
https://doi.org/10.1158/1535-7163.mct-09-0650
https://doi.org/10.1158/1535-7163.mct-09-0650
Autor:
Benjamin J. Roberts, Jeffrey A. Ucran, Mary L. Bouxsein, Jasbir Seehra, Amelia E. Pearsall, Monique V. Davies, Deepali Khanzode, Tod Marvell, R. Scott Pearsall, Kathryn W. Underwood, Ravindra Kumar, Travis E. Monnell, Roberto J. Fajardo, Rajaram K. Manoharan
Publikováno v:
Bone. 46:64-71
A recent study suggests that activin inhibits bone matrix mineralization, whereas treatment of mice with a soluble form of the activin type IIA receptor markedly increases bone mass and strength. To further extend these observations, we determined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6ebca4442ed11b941fc52adfa07cea
https://doi.org/10.1016/j.bone.2009.09.018
https://doi.org/10.1016/j.bone.2009.09.018
Autor:
Matthew L. Sherman, Ravindra Kumar, Yijun Yang, William Kramer, Kathryn W. Underwood, Jon Ruckle, Mark Jacobs, Amelia E. Pearsall, Jasbir Seehra, Carolyn H. Condon
Publikováno v:
Journal of Bone and Mineral Research. 24:744-752
The effects of ACE-011 on safety, pharmacokinetics, and bone biomarkers were evaluated in healthy, postmenopausal women. Our data indicate that ACE-011 results in a sustained increase in biomarkers of bone formation and reduction in markers of bone r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0052435ab149e98d1bbfd2278bb1d1
https://doi.org/10.1359/jbmr.081208
https://doi.org/10.1359/jbmr.081208
Autor:
Kristine Svenson, Kevin D. Parris, Robert M. Czerwinski, Elizabeth Federico, Scott Wolfrom, Jasbir Seehra, Jean-Baptiste Telliez, William S. Somers, Michelle Maguire, Karl Malakian, Mark Stahl, Ronald W. Kriz, Kathryn W. Underwood, Chu-Lai Hsiao, Tania Shane, Lih-Ling Lin, Meggin Taylor, Yan Liu, Lidia Mosyak
Publikováno v:
Structure. 11(6):627-636
MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41–364, in complex with staurosporine at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097acf64f2226a080302c56bfbe63f41
Autor:
John L. Knopf, Xiao Jia Chang, Kathryn W. Underwood, Lih-Ling Lin, Chuanzheng Song, Ronald W. Kriz
Publikováno v:
Journal of Biological Chemistry. 273:21926-21932
We report the cloning and characterization of a novel membrane-bound, calcium-independent PLA2, named cPLA2-gamma. The sequence encodes a 541-amino acid protein containing a domain with significant homology to the catalytic domain of the 85-kDa cPLA2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f587ebb0ff226eddc43dc917d1d55e5
https://doi.org/10.1074/jbc.273.34.21926
https://doi.org/10.1074/jbc.273.34.21926