Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kathryn Volkening"'
Autor:
Erin Santandrea, Farhang Aliakbari, Emily Truscott, Lynda McCaig, Neil S. Donison, Danielle Graham, Michael J. Strong, Kathryn Volkening
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract Ethical animal use follows the 3R’s: Replacement, Reduction and Refinement. Here, we present the use of simultaneous jugular vein and cisterna magna catheterization via a port system in rats for repeated fluid sampling for 14 consecutive d
Externí odkaz:
https://doaj.org/article/3a60acbbf2c14d86bd7a9e0e73227a25
Autor:
Neil Donison, Matthew Hintermayer, Maegha Subramaniam, Erin Santandrea, Kathryn Volkening, Michael J. Strong
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. While there
Externí odkaz:
https://doaj.org/article/2299cbd01d6043df929240c2af22b231
Autor:
Alexander J. Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J. Strong, Kathryn Volkening
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-17 (2019)
Abstract Although it has been suggested that the co-expression of multiple pathological proteins associated with neurodegeneration may act synergistically to induce more widespread neuropathology, experimental evidence of this is sparse. We have prev
Externí odkaz:
https://doaj.org/article/52c35f41852d404288e129d8e10bfe77
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
There is increasing acceptance that amyotrophic lateral sclerosis (ALS), classically considered a neurodegenerative disease affecting almost exclusively motor neurons, is syndromic with both clinical and biological heterogeneity. This is most evident
Externí odkaz:
https://doaj.org/article/2dbf93dba87a4f15833f0f672e207ed9
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5597 (2020)
The Rho guanine nucleotide exchange factor (RGNEF) protein encoded by the ARHGEF28 gene has been implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Biochemical and pathological studies have shown that RGNEF is a componen
Externí odkaz:
https://doaj.org/article/0bfcdea214e945e7a449eba58a2236d1
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 9, Pp 15592-15602 (2014)
MicroRNAs (miRNAs) are small non-coding RNAs that regulate the majority of the transcriptome at a post-transcriptional level. Because of this critical role, it is important to ensure that the assays used to determine their functionality are robust an
Externí odkaz:
https://doaj.org/article/914d4c3a70f940d3bf9a391b90b196e9
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85653 (2014)
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motor neuron degeneration and neurofilament aggregate formation. Spinal motor neurons in ALS also show a selective suppression in the levels of low molecular weight n
Externí odkaz:
https://doaj.org/article/ad0918614c60496fa36f4253683dae1c
Autor:
Michael J. Strong, Neil Donison, Matthew A. Hintermayer, Kathryn Volkening, Alexander J. Moszczynski
Publikováno v:
Journal of Neurochemistry. 155:313-326
One of the neuropathological hallmarks of the tauopathies is the formation of neuronal cytoplasmic inclusions and fibrils of microtubule-associated tau protein (tau). The phosphorylation of Thr175 of tau (pThr175 tau) appears to be sufficient for fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d884de7852929d12d1c43de881e7349b
https://doi.org/10.1111/jnc.14942
https://doi.org/10.1111/jnc.14942
Autor:
Adam D. McIntyre, Robert A. Hegele, Kathryn Volkening, Sali M.K. Farhan, Jian Wang, Jessica Kao, Lee Cyn Ang, Cheryl Leystra-Lantz, Michael J. Strong
Publikováno v:
Molecular and Cellular Biochemistry
Neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), can be clinically heterogeneous which may be explained by the co-inheritance of multiple genetic variants that modify the clinical course. In this study we examine variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e11966aa16f28bee1b32c5d928fdcd
https://pubmed.ncbi.nlm.nih.gov/33661429
https://pubmed.ncbi.nlm.nih.gov/33661429
Autor:
Estelle R. Bennett, Yousra Khalfallah, Benoit Chabot, Alexander J. Moszczynski, Michael J. Strong, Kathryn Volkening, Lulzim Shkreta, Christine Vande Velde, Aurélien Fouillen, Hermona Soreq, Laurie Destroismaisons, Antonio Nanci, Sabrina Semmler, Quentin Delmotte, Jade-Emmanuelle Deshaies, Stéphanie Stabile, Hadjara Sidibé, Uriya Bekenstein, Anaïs Aulas, Johanne Toutant
Publikováno v:
Brain. 141:1320-1333
See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.The RNA binding proteins TDP-43 (encoded by TARDBP) and hnRNP A1 (HNRNPA1) are each mutated in certain amyotrophic lateral sclerosis cases and are often misl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8301ea7e82e70f7d45762a49d89f0e51
https://doi.org/10.1093/brain/awy062
https://doi.org/10.1093/brain/awy062