Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathryn T. O'Leary"'
Publikováno v:
The Journal of Comparative Neurology. 510:655-672
Nicotinic acetylcholine receptors (nAChRs) mediate numerous visceral functions via medullary catecholamine (CA) neurons found in the nucleus tractus solitarius (NTS), dorsal motor nucleus of the vagus (DMV), and ventrolateral medulla (VLM). However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1a159688523fbade5bc65904af0eb6
https://doi.org/10.1002/cne.21833
https://doi.org/10.1002/cne.21833
Publikováno v:
Journal of Neurochemistry. 105:1861-1872
Despite a dramatic loss of nigrostriatal dopaminergic neurons in Parkinson’s disease, clinical symptoms only arise with 70–80% reduction of striatal dopamine. The mechanisms responsible for this functional compensation are currently under debate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73577dc4bb182d98e1f5b54d4cc872
https://doi.org/10.1111/j.1471-4159.2008.05268.x
https://doi.org/10.1111/j.1471-4159.2008.05268.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 325:646-654
The nicotine metabolite cotinine is an abundant long-lived bio-active compound that may contribute to the overall physiological effects of tobacco use. Although its mechanism of action in the central nervous system has not been extensively investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e3ca7f9928cbe76c59cc56ff3d5797
https://doi.org/10.1124/jpet.108.136838
https://doi.org/10.1124/jpet.108.136838
Publikováno v:
Molecular pharmacology. 75(4)
Brain dopaminergic systems are critical in motor control as evidenced by findings that their disruption results in movement disorders such as Parkinson's disease. Nicotinic acetylcholine receptor (nAChR) activation plays an important role in regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc590aca7083b10e06e85b44a55df5dc
https://pubmed.ncbi.nlm.nih.gov/19144785
https://pubmed.ncbi.nlm.nih.gov/19144785
Accumulating evidence suggests that nicotine, a drug that stimulates nicotinic acetylcholine receptors, may be of therapeutic value in Parkinson's disease. Beneficial effects may be several-fold. One of these is a protective action against nigrostria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41e69f5d13b00f1630e284baddc5664
https://europepmc.org/articles/PMC4430096/
https://europepmc.org/articles/PMC4430096/
Autor:
Neeraja Parameswaran, Kathryn T. O'Leary, Louisa C. Johnston, Maryka Quik, J. Michael McIntosh, Donato A. Di Monte
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 327(1)
Paraquat, an herbicide widely used in the agricultural industry, has been associated with lung, liver, and kidney toxicity in humans. In addition, it is linked to an increased risk of Parkinson's disease. For this reason, we had previously investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d48ca4e4640587914bea472b5f4228
https://pubmed.ncbi.nlm.nih.gov/18606871
https://pubmed.ncbi.nlm.nih.gov/18606871
Autor:
Maryka Quik, Heather Cox, Kathryn T. O'Leary, Donato A. Di Monte, Neeraja Parameswaran, J. William Langston
Publikováno v:
Annals of neurology. 62(6)
Objective Levodopa, the gold standard for Parkinson's disease treatment, is associated with debilitating abnormal involuntary movements or dyskinesias, for which few treatments are currently available. Studies have implicated numerous neurotransmitte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37eedb66b199c8fd5b15a25383fb700b
https://pubmed.ncbi.nlm.nih.gov/17960553
https://pubmed.ncbi.nlm.nih.gov/17960553
Publikováno v:
Biochemical pharmacology. 74(8)
Parkinson's disease is a debilitating neurodegenerative movement disorder characterized by damage to the nigrostriatal dopaminergic system. Current therapies are symptomatic only and may be accompanied by serious side effects. There is therefore a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7078ab749c2f3f9849f9f51952bc47d
https://pubmed.ncbi.nlm.nih.gov/17631864
https://pubmed.ncbi.nlm.nih.gov/17631864
Autor:
Kathryn T. O'Leary, Kathy A. Gallardo, Frances M. Leslie, Shahrdad Lotfipour, Layla Azam, Ryan M. Franke
Publikováno v:
Brain Development
Nicotine binds to specific cholinergic receptors. A nicotinic acetylcholine receptor (nAChR) is a ligand-gated cation channel. Each receptor consists of five subunit proteins surrounding a channel pore that mediate many of the biological effects of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2c2e006496a0d09d81d14ee8dc7301
https://doi.org/10.1093/acprof:oso/9780195183139.003.0023
https://doi.org/10.1093/acprof:oso/9780195183139.003.0023