Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kathryn R. Stein"'
Autor:
Andrea J. Parsons, Sabrina I. Ophir, J. Andrew Duty, Thomas A. Kraus, Kathryn R. Stein, Thomas M. Moran, Domenico Tortorella
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A panel of neutralizing human monoclonal antibodies targeting human cytomegalovirus offers a combination approach geared toward virus entry and replication to prevent viral dissemination.
Externí odkaz:
https://doaj.org/article/57b8ac30663040fb8418a4fe7637a724
Autor:
Anitha D. Jayaprakash, Adam J. Ronk, Abhishek N. Prasad, Michael F. Covington, Kathryn R. Stein, Toni M. Schwarz, Saboor Hekmaty, Karla A. Fenton, Thomas W. Geisbert, Christopher F. Basler, Alexander Bukreyev, Ravi Sachidanandam
Publikováno v:
Viruses, Vol 15, Iss 2, p 350 (2023)
The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental question is
Externí odkaz:
https://doaj.org/article/f3c460d6f5ec4fc486486a758e4a9e9e
Autor:
Kathryn R. Stein, Thomas J. Gardner, Rosmel E. Hernandez, Thomas A. Kraus, James A. Duty, Iban Ubarretxena-Belandia, Thomas M. Moran, Domenico Tortorella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Human cytomegalovirus (CMV) infects a wide range of host cells. Here, using a high throughput antibody screening platform, the authors identify the cell surface receptor CD46 to be required for CMV infection of epithelial cells and trophoblast-derive
Externí odkaz:
https://doaj.org/article/8106cc357234409b93e70c97eb7e4ea3
Autor:
Thomas J. Gardner, Kathryn R. Stein, J. Andrew Duty, Toni M. Schwarz, Vanessa M. Noriega, Thomas Kraus, Thomas M. Moran, Domenico Tortorella
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Human cytomegalovirus (CMV) poses a risk for immunosuppressed patients and newborns, with limited treatment options available. Here, Gardneret al. use a high-throughput approach and identify monoclonal antibodies that bind a highly conserved domain i
Externí odkaz:
https://doaj.org/article/991bb8c974f040b5b045baf0a89ab897
Autor:
Mohammad Amin Behzadi, Kathryn R. Stein, Maria Carolina Bermúdez-González, Viviana Simon, Raffael Nachbagauer, Domenico Tortorella
Publikováno v:
Vaccines, Vol 7, Iss 2, p 51 (2019)
Human cytomegalovirus (CMV) is a highly prevalent pathogen with ~60%−90% seropositivity in adults. CMV can contribute to organ rejection in transplant recipients and is a major cause of birth defects in newborns. Currently, there are no approved va
Externí odkaz:
https://doaj.org/article/59abbc105b6d42ab9e93acaf02681251
Autor:
Xiaohui Zhao, Kathryn R. Stein, Victor Chen, Matthew E. Griffin, Luke L. Lairson, Howard C. Hang
Publikováno v:
Nature Chemical Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd91f244d9fd39b24574f54c31e969e5
https://doi.org/10.1038/s41589-023-01328-z
https://doi.org/10.1038/s41589-023-01328-z
Publikováno v:
Nat Chem Biol
Bile acids are prominent host and microbiota metabolites that modulate host immunity and microbial pathogenesis. However, the mechanisms by which bile acids suppress microbial virulence are not clear. To identify the direct protein targets of bile ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ea6fa7f2894519e1c33ab9d9d56e81
https://europepmc.org/articles/PMC9805502/
https://europepmc.org/articles/PMC9805502/
Autor:
Andrea J. Parsons, Sabrina I. Ophir, Thomas J. Gardner, Jailene Casado Paredes, Kathryn R. Stein, Steven M. Kwasny, Steven C. Cardinale, Matthew Torhan, Mark N. Prichard, Scott H. James, Kristina E. Atanasoff, Narendran G-Dayanandan, Terry L. Bowlin, Timothy J. Opperman, Domenico Tortorella
Publikováno v:
Antiviral Research. 209:105474
Human cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes latent asymptomatic infections in healthy individuals but can cause serious infections in immunocompromised people, resulting in increased risk of morbidity and mortality. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc4316f8c6a98fd65200109a1564e
https://doi.org/10.1016/j.antiviral.2022.105474
https://doi.org/10.1016/j.antiviral.2022.105474
Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A
The microbiota generates diverse metabolites that can engage multiple pathways to modulate host physiology and disease, but their protein targets and mechanism(s) of action have not been fully elucidated. To address this challenge, we focused on indo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062f150e1d97e8e4584258ecf920a03e
https://doi.org/10.1101/2021.12.16.472979
https://doi.org/10.1101/2021.12.16.472979
Autor:
Andrea J. Parsons, Sabrina I. Ophir, J. Andrew Duty, Thomas A. Kraus, Kathryn R. Stein, Thomas M. Moran, Domenico Tortorella
Publikováno v:
Communications biology. 5(1)
Human cytomegalovirus (HCMV) is a β-herpesvirus that increases morbidity and mortality in immunocompromised individuals including transplant recipients and newborns. New anti-HCMV therapies are an urgent medical need for diverse patient populations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39327ff8c407bca4f74d6cad8a50f6f4
https://pubmed.ncbi.nlm.nih.gov/35468974
https://pubmed.ncbi.nlm.nih.gov/35468974