Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Kathryn R. Higgins"'
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Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation
Autor: Hannah M. Isles, Annemarie H. Meijer, Julien Rougeot, Stephen A. Renshaw, Kathryn R. Higgins, Caroline Tabor, Claudia Tulotta, Moira K. B. Whyte, Abigail E Reese, Atiqur Rahman, Aar Thompson, Lynne R. Prince, Kimberly D Herman, Katherine M. Henry, David H. Dockrell, Nika Khoshaein, Caroline O. S. Savage, David Sammut, William J. Zuercher, Ian Sabroe
Publikováno v: eLife
eLife, 8, e50990
Rahman, A, Henry, K M, Herman, K D, Thompson, A A, Isles, H M, Tulotta, C, Sammut, D, Rougeot, J J, Khoshaein, N, Reese, A E, Higgins, K, Tabor, C, Sabroe, I, Zuercher, W J, Savage, C O, Meijer, A H, Whyte, M K, Dockrell, D H, Renshaw, S A & Prince, L R 2019, ' Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation ', eLIFE, vol. 8 . https://doi.org/10.7554/eLife.50990
eLife, Vol 8 (2019)
Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b59e3fc62c3c598a92603ab84ee828
https://pubmed.ncbi.nlm.nih.gov/31613219
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3
NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival
Autor: Jennifer Carlring, Stephen A. Renshaw, Elizabeth C. Prestwich, Moira K. B. Whyte, Lynne R. Prince, Ian Sabroe, Atiqur Rahman, Svenja Dannewitz Prosseda, Alexander Basran, Nikolay V. Ogryzko, Kathryn R. Higgins, Francesco Falciani, Philip R. Taylor
Publikováno v: Prince, L R, Prosseda, S D, Higgins, K, Carlring, J, Prestwich, E C, Ogryzko, N V, Rahman, A, Basran, A, Falciani, F, Taylor, P, Renshaw, S A, Whyte, M K B & Sabroe, I 2018, ' NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival ', Blood, vol. 130, no. 8, pp. 1014–1025 . https://doi.org/10.1182/blood-2017-03-770164
The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular survival. Defects in neutrophil number and survival are common to both hematologic disorders and chronic inflammatory diseases. At sites of inflammation, n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6f69c123c3c2c3b7666a57920471e0
https://eprints.whiterose.ac.uk/118303/1/blood-2017-03-770164.full.pdf
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4
Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines
Autor: Sarah R. Walmsley, Lynne R. Prince, Clare A. Stokes, Stefanie N. Vogel, Elizabeth C. Prestwich, Ruth A. Sabroe, Lisa C. Parker, Lynne Bingle, Alexander Basran, Kathryn R. Higgins, Ian Sabroe, David H. Dockrell, Heather L. Wilson, Moira K. B. Whyte, Maisha Jabeen
Publikováno v: Basran, A, Jabeen, M, Bingle, L, Stokes, C A, Dockrell, D, Whyte, M K B, Walmsley, S R, Higgins, K R, Vogel, S N, Wilson, H L, Prince, L R, Prestwich, E C, Sabroe, R A, Parker, L C & Sabroe, I 2013, ' Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines ', Journal of Leukocyte Biology, vol. 93, no. 1, pp. 7-19 . https://doi.org/10.1189/jlb.0512250
Endotoxin-induced neutrophil recruitment in humans and its potential regulation by CXCL8 clearance. This study examined the establishment of neutrophilic inflammation in humans. We tested the hypotheses that neutrophil recruitment was associated with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af1213f054c7b9e2ad09c2b6d7ab332
https://doi.org/10.1189/jlb.0512250
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5
Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra
Autor: Lynne R. Prince, Clare A. Stokes, R. A. Sabroe, Ian Sabroe, Kathryn R. Higgins, Lisa C. Parker
Publikováno v: Clinical and experimental dermatology. 38(8)
Summary We report a man with lifelong urticaria, night sweats, arthralgia and lethargy. He had high levels of inflammatory markers and serum amyloid A, but no identifiable mutation in exon 3 of the NLRP3 (NOD-like receptor family, pyrin domain-1 cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c7b13ac3126a89f53d608e449d1e6f
https://pubmed.ncbi.nlm.nih.gov/23889084
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