Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathryn Pennel"'
Autor:
Katrina Knight, Christopher Bigley, Kathryn Pennel, Jennifer Hay, Noori Maka, Donald McMillan, James Park, Campbell Roxburgh, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 4, Pp n/a-n/a (2024)
Abstract Colorectal cancer remains a leading cause of mortality worldwide. Significant variation in response to treatment and survival is evident among patients with similar stage disease. Molecular profiling has highlighted the heterogeneity of colo
Externí odkaz:
https://doaj.org/article/cadf6fabd0114f8db531b733a3cd0118
Autor:
Phimmada Hatthakarnkul, Kathryn Pennel, Peter Alexander, Hester vanWyk, Antonia Roseweir, Jitwadee Inthagard, Jennifer Hay, Ditte Andersen, Noori Maka, James Park, Campbell Roxburgh, Chanitra Thuwajit, Donald McMillan, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 10, Iss 3, Pp n/a-n/a (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy and research is focused on identifying novel ways to subtype patients. In this study, a novel classification system, tumour microenvironment score (TMS), was devised based on Klintrup–M
Externí odkaz:
https://doaj.org/article/7cd476cd4b6e49e793cf072a26acb064
Autor:
Elizabeth Morrow, Kathryn Pennel, Phimmada Hatthakarnkul, Holly Leslie, Elizabeth Mallon, Ditte Andersen, Nigel Jamieson, Donald McMillan, Antonia Roseweir, Joanne Edwards
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13225-13240 (2023)
Abstract Introduction Triple‐negative breast cancer (TNBC) patients have the poorest clinical outcomes compared to other molecular subtypes of breast cancer. IL6/JAK/STAT3 signalling is upregulated in breast cancer; however, there is limited eviden
Externí odkaz:
https://doaj.org/article/b7f8d046e38e4a45a5c1b03fb306d1a4
Autor:
Sara SF Al‐Badran, Lauren Grant, Maejoy V Campo, Jitwadee Inthagard, Kathryn Pennel, Jean Quinn, Prakash Konanahalli, Liam Hayman, Paul G Horgan, Donald C McMillan, Campbell SD Roxburgh, Antonia Roseweir, James H Park, Joanne Edwards
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 7, Iss 2, Pp 121-134 (2021)
Abstract The tumour microenvironment is an important factor for colorectal cancer prognosis, affecting the patient's immune response. Immune checkpoints, which regulate the immune functions of lymphocytes, may provide prognostic power. This study aim
Externí odkaz:
https://doaj.org/article/a3ff5f9d8dbd4c0faf511ffc1822eba4
Autor:
Elizabeth Morrow, Kathryn Pennel, Phimmada Hatthakarnkul, Holly Leslie, Elizabeth Mallon, Ditte Andersen, Nigel Jamieson, Donald McMillan, Antonia Roseweir, Joanne Edwards
Publikováno v:
Cancer Medicine.
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
All supplemental figures and legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cee3a26e547749f005f869f86f6004e
https://doi.org/10.1158/2159-8290.22540555
https://doi.org/10.1158/2159-8290.22540555
Autor:
Owen J. Sansom, Martin Bushell, Anne E. Willis, Joanne Edwards, John Le Quesne, William J. Faller, Heather J. McKinnon, Martin E. Swarbrick, Neil P. Jones, Christopher G. Proud, Nahum Sonenberg, Kevin M. Haigis, Nicola Valeri, Georgios Vlachogiannis, Andrew D. Campbell, Joseph A. Waldron, Rene Jackstadt, Joshua D. Leach, Emma Stanway, Kerri McArthur, Anne Cheasty, Craig MacKay, Laura McDonald, Rachael C.L. Smith, Dustin J. Flanagan, Rachel A. Ridgway, Kathryn Gilroy, Arafath K. Najumudeen, Ewan M. Smith, Sebastian May-Wilson, David M. Gay, Georgios Kanellos, Ana Teodosio, Leah Officer, Kathryn Pennel, Nikola Vlahov, George L. Skalka, Constantinos Alexandrou, John R.P. Knight
KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f56670615fce027f717d8d9f47081b8
https://doi.org/10.1158/2159-8290.c.6549409
https://doi.org/10.1158/2159-8290.c.6549409
Autor:
John R P, Knight, Constantinos, Alexandrou, George L, Skalka, Nikola, Vlahov, Kathryn, Pennel, Leah, Officer, Ana, Teodosio, Georgios, Kanellos, David M, Gay, Sebastian, May-Wilson, Ewan M, Smith, Arafath K, Najumudeen, Kathryn, Gilroy, Rachel A, Ridgway, Dustin J, Flanagan, Rachael C L, Smith, Laura, McDonald, Craig, MacKay, Anne, Cheasty, Kerri, McArthur, Emma, Stanway, Joshua D, Leach, Rene, Jackstadt, Joseph A, Waldron, Andrew D, Campbell, Georgios, Vlachogiannis, Nicola, Valeri, Kevin M, Haigis, Nahum, Sonenberg, Christopher G, Proud, Neil P, Jones, Martin E, Swarbrick, Heather J, McKinnon, William J, Faller, John, Le Quesne, Joanne, Edwards, Anne E, Willis, Martin, Bushell, Owen J, Sansom
Publikováno v:
Cancer Discov
KRAS-mutant colorectal cancers (CRC) are resistant to therapeutics, presenting a significant problem for ~40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant CRC. Using Kras-mutant mou
Autor:
Kathryn Pennel, David W. Hill, Adam S. Venable, Brian K. McFarlin, Jill N. Best Sampson, Jakob L. Vingren, Andrea L. Henning
Publikováno v:
BBA Clinical
Background Exercise-Induced Muscle Damage (EIMD) and delayed onset muscle soreness (DOMS) impact subsequent training sessions and activities of daily living (ADL) even in active individuals. In sedentary or diseased individuals, EIMD and DOMS may be