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pro vyhledávání: '"Kathryn P. Sherry"'
Autor:
Andrea A. Carter, Kristen M. Ramsey, Christine L. Hatem, Kathryn P. Sherry, Ananya Majumdar, Doug Barrick
Publikováno v:
Structure. 31:584-594.e5
Publikováno v:
Journal of Molecular Biology. 427:3587-3597
Formation of the bivalent interaction between the Notch intracellular domain (NICD) and the transcription factor CBF-1/RBP-j, Su(H), Lag-1 (CSL) is a key event in Notch signaling because it switches Notch-responsive genes from a repressed state to an
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(44)
Intrinsically disordered regions (IDRs) play important roles in proteins that regulate gene expression. A prominent example is the intracellular domain of the Notch receptor (NICD), which regulates the transcription of Notch-responsive genes. The NIC