Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kathryn N Ivey"'
Autor:
Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena, Anley E. Tefera, Reva Shenwai, Farshad Farshidfar, Melissa Van Pell, Emma Xu, Chris Reid, Neshel Rodriguez, Beatriz Lim, Tae Won Chung, Joseph Woods, Aquilla Scott, Samantha Jones, Cristina Dee-Hoskins, Carolina G. Gutierrez, Jessie Madariaga, Kevin Robinson, Yolanda Hatter, Renee Butler, Stephanie Steltzer, Jaclyn Ho, James R. Priest, Xiaomei Song, Frank Jing, Kristina Green, Kathryn N. Ivey, Timothy Hoey, Jin Yang, Zhihong Jane Yang
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-19 (2024)
Abstract Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address t
Externí odkaz:
https://doaj.org/article/44e0349c7b784de384ccd674ac140a80
Autor:
Amy Heidersbach, Chris Saxby, Karen Carver-Moore, Yu Huang, Yen-Sin Ang, Pieter J de Jong, Kathryn N Ivey, Deepak Srivastava
Publikováno v:
eLife, Vol 2 (2013)
microRNA-1 (miR-1) is an evolutionarily conserved, striated muscle-enriched miRNA. Most mammalian genomes contain two copies of miR-1, and in mice, deletion of a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defect
Externí odkaz:
https://doaj.org/article/7e574b2d00aa47e2b8ec607b379d5148
Autor:
Riham R.E. Abouleisa, Abou Bakr M. Salama, Qinghui Ou, Xian-Liang Tang, Mitesh Solanki, Yiru Guo, Yibing Nong, Lindsey McNally, Pawel K. Lorkiewicz, Kamal M. Kassem, Brooke M. Ahern, Krishna Choudhary, Reuben Thomas, Yu Huang, Hamzah R. Juhardeen, Aisha Siddique, Zainab Ifthikar, Sally K. Hammad, Ayman S. Elbaz, Kathryn N. Ivey, Daniel J. Conklin, Jonathan Satin, Bradford G. Hill, Deepak Srivastava, Roberto Bolli, Tamer M.A. Mohamed
Publikováno v:
Circulation, vol 145, iss 17
Circulation
Circulation
Background: The regenerative capacity of the heart after myocardial infarction is limited. Our previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin-dependent kinase 1], CDK4 [cyclin-dependent kinase 4], CCNB [cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249a499faef816968a494e25e7f08a68
https://escholarship.org/uc/item/56t1k1cp
https://escholarship.org/uc/item/56t1k1cp
Autor:
Deepak Srivastava, Stacia K. Wyman, Ping Zhou, T. Yvanka de Soysa, Arye Elfenbein, Sanjeev S. Ranade, Yen Kim Bui, Casey A. Gifford, Kimberly R. Cordes Metzler, Yu Huang, Ryan Samarakoon, Kathryn N. Ivey, Hazel T. Salunga, Philip C. Ursell
Publikováno v:
Science (New York, N.Y.), vol 364, iss 6443
Three rights can make a wrong Many diseases are thought to arise from co-inheritance of rare genetic variants that are benign on their own but harmful in combination. This hypothesis has been difficult to validate by functional experiments. Gifford e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00568a2c22949ded186e3bb8806a7ec
https://doi.org/10.1126/science.aat5056
https://doi.org/10.1126/science.aat5056
Autor:
Riham Abouleisa, Qinghui Ou, Xian-liang Tang, Mitesh Solanki, Yiru Guo, Lindsey McNally, Pawel Lorkiewicz, Krishna Choudhary, Reuben Thomas, Hamzah Ruxshan Juhardeen, Aisha Siddique, Zainab Ifthikar, Abou Bakr Salama, Yu Huang, Kathryn N Ivey, Bradford Hill, Deepak Srivastava, Roberto Bolli, Tamer Mohamed
Publikováno v:
Circulation. 142
Rationale: The regenerative capacity of the heart to repair itself after myocardial infarction (MI)is limited. Our previous study showed that ectopic introduction of Cdk1/CyclinB1 andCdk4/CyclinD1 complexes (4F) promotes cardiomyocyte proliferation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e5f6a76e99212478c91da137297905
https://doi.org/10.1161/circ.142.suppl_3.14391
https://doi.org/10.1161/circ.142.suppl_3.14391
Autor:
Arun Padmanabhan, Katherine S. Pollard, Joshua G. Travers, Ricardo Linares-Saldana, Kathryn N. Ivey, Pawel F. Przytycki, Jin Yang, Michael G. Rosenfeld, Barbara Gonzalez Teran, Franco Felix, Gaia Andreoletti, Qiming Duan, Deepak Srivastava, Michael Alexanian, Rudi Micheletti, Sanjeev S. Ranade, Saptarsi M. Haldar, Lin Ye, Yu Huang, Casey A. Gifford, Rajan Jain, Timothy A. McKinsey
In diseased organs, stress-activated signaling cascades alter chromatin, triggering broad shifts in transcription and cell state that exacerbate pathology. Fibroblast activation is a common stress response that worsens lung, liver, kidney and heart d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f822752ed23f4eccecada4498b5950e0
https://doi.org/10.1101/2020.07.21.214874
https://doi.org/10.1101/2020.07.21.214874
Autor:
Jun-yi Zhu, Irfan S. Kathiriya, Zhe Han, Bayardo I. Garay, Isabelle N. King, Kathryn N. Ivey, Amy Heidersbach, Deepak Srivastava
Publikováno v:
Journal of Cell Science, vol 130, iss 6
miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle and embryonic heart development, which have been partly attributed to miR-1 directly targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5ba245d360affc77af51ae08189913
https://doi.org/10.1242/dev.140368
https://doi.org/10.1242/dev.140368
Autor:
Zoë Jacobson, Ayman Al-Baz, Steven P. Jones, Bradford G. Hill, Xian-Liang Tang, Ashok Kumar, Kathryn N. Ivey, Roberto Bolli, Guruprasad A. Giridharan, Benjamin Rood, Qinghui Ou, Tamer M.A. Mohamed, Riham Abou-Leisa, Sajedah M. Hindi, Kenneth R. Brittian
Publikováno v:
Circulation Research. 125
Rationale: Heart failure is the number one killer and drug induced cardiotoxicity is a major cause of market withdrawal. The lack of availability of culture systems for human heart tissue that is functionally and structurally viable for more than 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ba7b590ab8d350128555aeaac3de2f2
https://doi.org/10.1161/res.125.suppl_1.208
https://doi.org/10.1161/res.125.suppl_1.208
Autor:
Ying-Hsi Lin, Guruprasad A. Giridharan, Riham Abou-Leisa, Zoë Jacobson, Cesare M. Terracciano, Samuel A. Watson, Timothy A. McKinsey, Tamer M.A. Mohamed, Sajedah M. Hindi, Ashok Kumar, Ayman El-Baz, Filippo Perbellini, Kenneth R. Brittian, Roberto Bolli, Xian-Liang Tang, Steven P. Jones, Bradford G. Hill, Qinghui Ou, Benjamin Rood, Kathryn N. Ivey
Publikováno v:
Circ Res
Ou, Q, Jacobson, Z, Abouleisa, R, Tang, X-L, Hindi, S, Kumar, A, Ivey, K N, Giridharan, G A, Al-Baz, A, Brittian, K, Rood, B, Lin, Y-H, Watson, S A, Perbellini, F, McKinsey, T A, Hill, B G, Jones, S P, Terracciano, C M, Bolli, R & Mohamed, T M 2019, ' A Physiological Biomimetic Culture System for Pig and Human Heart Slices ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.119.314996
Ou, Q, Jacobson, Z, Abouleisa, R, Tang, X-L, Hindi, S, Kumar, A, Ivey, K N, Giridharan, G A, Al-Baz, A, Brittian, K, Rood, B, Lin, Y-H, Watson, S A, Perbellini, F, McKinsey, T A, Hill, B G, Jones, S P, Terracciano, C M, Bolli, R & Mohamed, T M 2019, ' A Physiological Biomimetic Culture System for Pig and Human Heart Slices ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.119.314996
Rationale: Preclinical testing of cardiotoxicity and efficacy of novel heart failure therapies faces a major limitation: the lack of an in situ culture system that emulates the complexity of human heart tissue and maintains viability and functionalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cc34e033f9830568e6ca3e987b547c
https://europepmc.org/articles/PMC6715512/
https://europepmc.org/articles/PMC6715512/
Autor:
Reuben Thomas, Karishma Pratt, Kaitlen Samse-Knapp, Lin Ye, Ethan Radzinsky, Joke G. van Bemmel, Nicole Stone, Kathryn N. Ivey, Casey A. Gifford, Amelia Schricker, Tamer M.A. Mohamed, Pengzhi Yu, Deepak Srivastava, Katherine S. Pollard
Publikováno v:
Cell stem cell, vol 25, iss 1
Cell Stem Cell
Stone, N R, Gifford, C A, Thomas, R, Pratt, K J B, Samse-Knapp, K, Mohamed, T M A, Radzinsky, E M, Schricker, A, Ye, L, Yu, P, van Bemmel, J G, Ivey, K N, Pollard, K S & Srivastava, D 2019, ' Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming ', Cell Stem Cell, vol. 25, no. 1, pp. 87-102.e9 . https://doi.org/10.1016/j.stem.2019.06.012
Cell Stem Cell
Stone, N R, Gifford, C A, Thomas, R, Pratt, K J B, Samse-Knapp, K, Mohamed, T M A, Radzinsky, E M, Schricker, A, Ye, L, Yu, P, van Bemmel, J G, Ivey, K N, Pollard, K S & Srivastava, D 2019, ' Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming ', Cell Stem Cell, vol. 25, no. 1, pp. 87-102.e9 . https://doi.org/10.1016/j.stem.2019.06.012
Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d33d2776d4d5a4bda36294362c2e3b
https://escholarship.org/uc/item/5063d4vp
https://escholarship.org/uc/item/5063d4vp