Výsledky vyhledávání - "Kathryn McLean"

Akademický článek

Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection

Autor: Kelsi Penewit, Elizabeth A. Holmes, Kathryn McLean, Mingxin Ren, Adam Waalkes, Stephen J. Salipante

Publikováno v: mBio, Vol 9, Iss 1 (2018)

ABSTRACT Staphylococcus aureus is an important human pathogen, but studies of the organism have suffered from the lack of a robust tool set for its genetic and genomic manipulation. Here we report the development of a system for the facile and high-t

Externí odkaz: https://doaj.org/article/bc80c69d71cf43f2813b54ad9b9b729a

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Akademický článek

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa

Autor: Peter Jorth, Kathryn McLean, Anina Ratjen, Patrick R. Secor, Gilbert E. Bautista, Sumedha Ravishankar, Amir Rezayat, Jayanthi Garudathri, Joe J. Harrison, Rachel A. Harwood, Kelsi Penewit, Adam Waalkes, Pradeep K. Singh, Stephen J. Salipante

Publikováno v: mBio, Vol 8, Iss 5 (2017)

ABSTRACT While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, w

Externí odkaz: https://doaj.org/article/3789d0f4355743ab928140bb13ba807a

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Diagnosis of Ovarian Carcinoma Homologous Recombination DNA Repair Deficiency From Targeted Gene Capture Oncology Assays

Autor: Niklas Krumm, Nithisha S. Khasnavis, Marc Radke, Kalyan Banda, Helen R. Davies, Christopher Pennil, Kathryn McLean, Vera A. Paulson, Eric Q. Konnick, Winslow C. Johnson, Grogan Huff, Serena Nik-Zainal, Elizabeth M. Swisher, Christina M. Lockwood, Stephen J. Salipante

Publikováno v: JCO Precision Oncology.

PURPOSE Homologous recombination DNA repair deficiency (HRD) is a therapeutic biomarker for sensitivity to platinum and poly(ADP-ribose) polymerase inhibitor therapies in breast and ovarian cancers. Several molecular phenotypes and diagnostic strateg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ec9900bc901330ef487b6ab6276aa36
https://doi.org/10.1200/po.22.00720

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Polyclonality, Shared Strains, and Convergent Evolution in Chronic Cystic Fibrosis Staphylococcus aureus Airway Infection

Autor: Stephen J. Salipante, Dustin R. Long, Kathryn McLean, Kelsi Penewit, Daniel J. Wolter, Adam Waalkes, Michael Lee, Elizabeth E. Holmes, Lucas R. Hoffman, Mimi R. Precit

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 203:1127-1137

Rationale: Staphylococcus aureus is the most common respiratory pathogen isolated from patients with cystic fibrosis (CF) in the United States. Although modes of acquisition and genetic adaptation ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56c4f58b6bbcb7959081611b8c255081
https://doi.org/10.1164/rccm.202003-0735oc

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Occurrence of cross-resistance and β-lactam seesaw effect in glycopeptide-, lipopeptide- and lipoglycopeptide-resistant MRSA correlates with membrane phosphatidylglycerol levels

Autor: Tianwei Shen, Brian J. Werth, Libin Xu, Elizabeth A. Holmes, Kelly M. Hines, Kathryn McLean, Nathaniel K Ashford, Adam Waalkes, Stephen J. Salipante, Kelsi Penewit

Publikováno v: J Antimicrob Chemother

Background Glycopeptides (GPs), lipopeptides (LPs) and lipoglycopeptides (LGPs) are related antimicrobials important for the management of invasive MRSA infections. Cross-resistance among these antibiotics in MRSA is well documented, as is the observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763afc5a0ab165d5d3741f22e0a125ea
https://doi.org/10.1093/jac/dkz562

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Whole-genome sequencing of clinical Clostridioides difficile isolates reveals molecular epidemiology and discrepancies with conventional laboratory diagnostic testing

Autor: Stephen J. Salipante, J.-M. Balada-Llasat, Adam Waalkes, P. Pancholi, Kathryn McLean

Publikováno v: The Journal of hospital infection. 108

Summary Background The high clinical burden of Clostridioides difficile infections merits rapid and sensitive identification of affected individuals. However, effective diagnosis remains challenging. Current best practice guidelines recommend molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68a7e6b268a8762b7f4f02fc81a067d
https://pubmed.ncbi.nlm.nih.gov/33227298

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Improved Species-Level Clinical Identification of Enterobacteriaceae through Broad-Range dnaJ PCR and Sequencing

Autor: Dhruba J. Sengupta, Brad T. Cookson, Stephen J. Salipante, Noah G. Hoffman, Jennifer Owens, Kathryn McLean, Christopher Rosenthal

Publikováno v: Journal of Clinical Microbiology. 57

Enterobacteriaceae represent a diverse and medically important family of bacteria that are difficult to identify to the species level using the standard molecular method of 16S rRNA gene sequencing. Prior work has demonstrated the value of dnaJ gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::456a9f1d5fa593ca14ee73f6c71ee1b7
https://doi.org/10.1128/jcm.00986-19

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